Specifications
- Purity
- ≥95% (HPLC)
- Appearance
- White to yellow powder
- Identity
- 1H-NMR
Properties
- Solvents
- water (slighly), acetic acid
- Melting Point
- 148-150°C (lit.)
Category: Phytochemicals
Methoxsalen (8-Methoxypsoralen) is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450). Has more potency than 5-MOP, 5-OH-P, DH-8-MOP and psoralen in inhibiting CYP2B1 (cytochrome P-450 2B1). Completely inhibits the metabolism of nicotine in vitro. Inhibits the metabolism of caffeine. Methoxsalen is a drug with photoactivating properties used to treat psoriasis, eczema, vitiligo and some cutaneous lymphomas in conjunction with exposing the skin to UVA light. Upon photoactivation, ultraviolet A (UVA) irradiation induces monoadducts and interstrand cross-links in DNA and therefore can be used to study DNA repair and recombination mechanisms.
Synonyms | 8-MP, 8-MOP, 8-Methoxy-6,7-furanocoumarin, 9-Methoxyfuro[3,2-g][1]benzopyran-7-one, 5-Demethoxyisoimpinellin, Ammoidin, Methoxsalen, Xanthotoxin |
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Purity | ≥95% (HPLC) |
Appearance | White to yellow powder |
CAS-Number | 298-81-7 |
Molecular Formula | C12H8O4 |
Molecular Weight | 216.19 |
Identity | 1H-NMR |
Solvents | water (slighly), acetic acid |
Melting Point | 148-150°C (lit.) |
Smiles | COC1=C2C(=CC3=C1OC=C3)C=CC(=O)O2 |
InChi Key | QXKHYNVANLEOEG-UHFFFAOYSA-N |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Hazard statements | H302-H317 |
Precautionary statements | P280 |
GHS Symbol | GHS07+GHS08 |
Signal word | Warning |
Transportation | Not dangerous goods |
References | (1) A. Lassus, et al., Photodermatol. 1, 170 (1984), (2) F.A. de Wolff, et al., Clin. Pharmacokinet. 11, 62 (1986), (3) G. Labbe, et al., Biochem. Pharmacol. 36, 907 (1987), (4) D.C. Mays, et al., Clin. Pharmacol. Ther. 42, 621 (1987), (5) G. Labbe, et al., J. Pharmacol. Exp. Ther. 250, 1034 (1989), (6) H.G. Jeong, et al., BBRC 208, 1124 (1995), (7) J.H. Gwang, Cancer Lett. 109, 115 (1996), (8) M. Farhadi, et al., Cell J. 15, 348 (2014), (9) D. Bagdas, et al., Neuropharmacol. 85, 67 (2014) |
Quantity | 5 g, Bulk |