Specifications
- Purity
- ≥97% (HPLC)
- Appearance
- White solid
- Identity
- 1H-NMR
Properties
- Solvents
- DMF
- Melting Point
- 259-262 °C (lit.)
Downloads
- Safety Data Sheet
- CDX D0318 MSDS.pdf
Category: Metabolites
A puromycin analog that acts as a protein kinase inhibitor. Selectively induces premature mitosis in mammalian cells. Inhibits TNF-alpha upregulation of ICAM-1, lipolysis, and the activation of JNK/SAPK. Inhibits p34cdc2/cyclin B (IC50 = 300 µM). Induces apoptosis in S-phase-arrested HeLa cells (~5 mM).
Synonyms | 6-DMAP, N6,N6-Dimethyladenine |
---|---|
Purity | ≥97% (HPLC) |
Appearance | White solid |
CAS-Number | 938-55-6 |
Molecular Formula | C7H9N5 |
Molecular Weight | 163.18 |
Identity | 1H-NMR |
Solvents | DMF |
Melting Point | 259-262 °C (lit.) |
Smiles | CN(C)C1=C2NC=NC2=NC=N1 |
InChi Key | BVIAOQMSVZHOJM-UHFFFAOYSA-N |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | +4°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
Transportation | Not dangerous goods |
References | (1) H. Bredereck et al.: Berichte der Deutschen Chemischen Gesellschaft 73B, 1058-65 (1940), (2) J. Vesely et al.: European Journal of Biochemistry 224(2), 771-86 (1994), (3) P. Chesne et al.: Nature Biotechnology 20(4), 366-369 (2002) |
InChi | InChI=1S/C7H9N5/c1-12(2)7-5-6(9-3-8-5)10-4-11-7/h3-4H,1-2H3,(H,8,9,10,11) |
Quantity | 1 g, Bulk |