Specifications
- Purity
- ≥97% (HPLC)
- Appearance
- White to off-white powder
- Identity
- 1H-NMR
Properties
- Solvents
- water (50 mg/ml), DMSO (slightly), ethanol, methanol (10mg/ml)
Downloads
- Safety Data Sheet
- CDX G0033 MSDS.pdf
Category: Steroids
Glycochenodeoxycholic acid (GCDCA) is a bile salt formed in the liver that acts as a biosurfactant to solubilize lipids for absorption and is itself absorbed. GCDCA functions as a choleretic, increasing the volume of bile secreted from the liver, and a cholagogue, promoting the discharge of bile from the digestive system. GCDCA has been used to demonstrate a role for bile acids in promoting colorectal carcinogenesis and to inhibit calcium hydroxyapatite precipitation to study the pathogenesis of black pigment gallstones. This product has also been shown to induce apoptosis in isolated hepatocytes via modulation of PKC activity. This compound is used as an anionic detergent to solubilize lipids and as a chiral reagent.
Synonyms | 3α,7α-Dihydroxy-5β-cholanoic acid N-(carboxymethyl)amide sodium salt, Glycochenodeoxycholic acid sodium salt, N-(3α,7α-Dihydroxy-24-oxocholan-24-yl)glycine sodium salt |
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Purity | ≥97% (HPLC) |
Appearance | White to off-white powder |
CAS-Number | 16564-43-5 |
Molecular Formula | C26H42NNaO5 |
Molecular Weight | 471.61 |
Identity | 1H-NMR |
Solvents | water (50 mg/ml), DMSO (slightly), ethanol, methanol (10mg/ml) |
Smiles | [H][C@]1([C@@H](CCC(NCC(O[Na])=O)=O)C)CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C |
InChi Key | AAYACJGHNRIFCT-YRJJIGPTSA-M |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Transportation | Not dangerous goods |
References | (1) S. Barnes, et al., J. Lipid Res. 20, 952 (1979), (2) S.M. Qiu, et al., J. Clin. Invest. 88, 1265 (1991), (3) B. Gonzalez, et al., Mol. Cell. Biochem. 207, 19 (2000), (4) M. Iwata, et al., Hepatol. Res. 25, 329 (2003), (5) S. Ishizuka, et al., Biomed. Res. 33, 159 (2012) |
Quantity | 500 mg, 1 g, Bulk |