Specifications
- Purity
- ≥99% (HPLC)
- Appearance
- Off-white powder
- Identity
- 1H-NMR
Properties
- Solvents
- water (10 mg/ml), chloroform, DMSO
- Melting Point
- 270° C
Category: Metabolites
5-hydroxy-L-Tryptophan (5-HTP), also known as oxitriptan, is a naturally occurring amino acid and chemical precursor as well as a metabolic intermediate in the biosynthesis of the neurotransmitter serotonin. It is used as a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid. It is also used as L-aromatic amino acid decarboxylase substrate. When injected systemically in animals, 5-HTP is converted to serotonin and has both peripheral and central nervous system effects. 5-HTP can also be synthesized by gut microbiota and acts as an activator of the aryl hydrocarbon receptor.
Synonyms | Oxitriptan, 5-HTP, L-2-Amino-3-(5-hydroxyindolyl)propionic acid, L-5-HTTP, L-5-Hydroxytryptophan |
---|---|
Purity | ≥99% (HPLC) |
Appearance | Off-white powder |
CAS-Number | 4350-09-8 |
Molecular Formula | C11H12N2O3 |
Molecular Weight | 220.22 |
Identity | 1H-NMR |
Solvents | water (10 mg/ml), chloroform, DMSO |
Melting Point | 270° C |
Smiles | C1=CC2=C(C=C1O)C(=CN2)C[C@@H](C(=O)O)N |
InChi Key | LDCYZAJDBXYCGN-VIFPVBQESA-N |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | +4°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
Hazard statements | H301 |
Precautionary statements | P264, P270, P301 + P310 + P330, P405, P501 |
GHS Symbol | GHS06 |
Signal word | Danger |
RIDADR | UN2811 6.1 |
Transportation | Packing Group III |
References | (1) A. Carlsson, et al., Nature 180, 1200 (1957), (2) A. Boiardi, et al., J. Neurol. 225, 41 (1981), (3) T.C. Birdsall, Altern. Med. Rev. 3, 271 (1998), (4) A. Martinez, et al., Curr. Med. Chem. 8, 1077 (2001), (5) E.H. Turner, et al., Pharmacol. Ther. 109, 325 (2006), (6) C.L. Schmid & L.M. Bohn, J. Neurosci. 30, 13513 (2010), (7) G.V. Sridharan, et al., Nat. Commun. 5, 5492 (2014), (8) R. Haberzettl, et al., Behav. Brain Res. 277, 204 (2015), (9) J.-A. Mora-Villalobos & A.-P. Zeng, J. Biol. Eng. 12, 3 (2018) |
Quantity | 1 g, 5 g, 25 g, Bulk |