Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- Dark red to brown powder
- Identity
- 1H-NMR
- UV/Vis
- λmax 778-788 nm in methanol
Properties
- Solvents
- methanol, water
- Melting Point
- 231-233 °C
Category: Fluorescent Detection, Fluorescent Detection
IR-783 is a functional laser and near-IR (NIR) dye. Spectral data: Absorption &lambda|max=783nm (MeOH). IR-783 has been shown to be a dye that exhibits imaging, cancer targeting and anticancer properties. Useful optical probe for NIR imaging of tumors, shown to accumulate in the mitochondria and lysosomes of cancer cells. IR-783 inhibits cell viability and induces mitochondrial apoptosis in human breast cancer cells and induces cell proliferation in a dose? and time?dependent manner by inducing cell cycle arrest at the G0/G1 phase.
Synonyms | 2-[2-[2-Chloro-3-[2-[1,3-dihydro-3,3-dimethyl-1-(4-sulfobutyl)-2H-indol-2-ylidene]-ethylidene]-1-cyclohexen-1-yl]-ethenyl]-3,3-dimethyl-1-(4-sulfobutyl)-3H-indolium hydroxide, inner salt sodium salt |
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Purity | ≥98% (HPLC) |
Appearance | Dark red to brown powder |
CAS-Number | 115970-66-6 |
Molecular Formula | C38H46ClN2NaO6S2 |
Molecular Weight | 749.37 |
Identity | 1H-NMR |
Solvents | methanol, water |
Melting Point | 231-233 °C |
Smiles | ClC1=C(/C=C/C2=[N+](CCCCS(=O)(O[Na])=O)C3=C(C=CC=C3)C2(C)C)CCC/C1=CC=C4N(CCCCS(=O)([O-])=O)C(C=CC=C5)=C5C/4(C)C |
InChi Key | QQIQAVJARACLHE-UHFFFAOYSA-M |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Transportation | Not dangerous goods |
References | (1) K. Leung, Mol. Imag. Contrast Agent Datab. (2010), (2) X. Yang, et al., Clin. Cancer Res. 16, 2833 (2010), (3) K. Leung, Mol. Imag. Contrast Agent Datab. (2011), (4) X. Yang, et al., J. Urol. 189, 702 (2013), (1) C. Shao, et al., PLoS One 9, e88967 (2014), (6) I. Semenenko, et al., Front. Pharmacol. 7, 426 (2016), (7) Q. Tang, et al., J. Cell Mol. Med. 22, 4474 (2018), (8) P. Li, et al., Int. J. Oncol. 55, 415 (2019) |
Quantity | 250 mg, Bulk |
cdx-UV/Vis | λmax 778-788 nm in methanol |