4-Methylumbelliferone
- SKU
- M0007
Category: Fluorescent Detection, Fluorescent Detection
- Synonyms
- beta-Methylumbelliferone , 4-MU , 7-Hydroxy-4-methylcoumarin , 7-Hydroxy-4-methyl-2H-1-benzopyran-2-one , 7-Hydroxy-4-methyl-2-chromenone , NSC 19026 , NSC 9408 , Omega 127 , Pilot 447
- 90-33-5
- CAS-Number
- C10H8O3
- Molecular Formula
- 176.17
- Molecular Weight
Specifications
- Purity
- ≥95% (NMR)
- Appearance
- Off white to beige powder
- Identity
- 1H-NMR
Properties
- Solvents
- methanol (50 mg/ml), glacial acetic acid, ether (slightly), chloroform (slightly), water (practically insoluble)
- Melting Point
- 185-190 °C
Downloads
- Safety Data Sheet
- CDX M0007 MSDS.pdf
- Shipping
- AMBIENT
- Short Term Storage
- RT
- Long Term Storage
- RT
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at RT.
- Transportation
- Not dangerous goods
- Description
- "4-Methylumbelliferone (4-MU) is a selective inhibitor of hyaluronan (HA) by depletion of UDP-glucuronic acid, the common substrate for HA synthesis and downregulation of hyaluronan synthase 2 and 3, MMP2 and MMP9. Since hyaluronan (HA) is a major component of the extracellular matrix that is synthesized in excess in cancer tissues, 4-MU has been shown to have anti-cancer activity and is involved in angiogenesis, invasion and metastasis of cancer.
- Smiles
- CC1=CC(=O)OC2=C1C=CC(=C2)O
- InChi Key
- HSHNITRMYYLLCV-UHFFFAOYSA-N
“4-Methylumbelliferone (4-MU) is a selective inhibitor of hyaluronan (HA) by depletion of UDP-glucuronic acid, the common substrate for HA synthesis and downregulation of hyaluronan synthase 2 and 3, MMP2 and MMP9. Since hyaluronan (HA) is a major component of the extracellular matrix that is synthesized in excess in cancer tissues, 4-MU has been shown to have anti-cancer activity and is involved in angiogenesis, invasion and metastasis of cancer.