3-Methyladenine
- SKU
- M0203
Category: Building Blocks, Intermediates, Reagents
- Synonyms
- 3-MA , 3MeA , 6-Amino-3-methylpurine , NSC 66389
- 5142-23-4
- CAS-Number
- C6H7N5
- Molecular Formula
- 149.15
- Molecular Weight
Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White to off-white powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO (10 mg/ml), water (5 mg/ml), DMF (10 mg/ml), ethanol
- Melting Point
- ~300 °C (dec.)(lit.)
- Boiling Point
- 240 °C
- Refractive Index
- n20D 1.81 (Predicted)
- Density
- 1.6 g/cm3
- Other
- pKb: 6.77 (Predicted)
Downloads
- Safety Data Sheet
- CDX M0203 MSDS.pdf
- Shipping
- AMBIENT
- Short Term Storage
- +4°C
- Long Term Storage
- -20°C
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at -20°C.
- Transportation
- Not dangerous goods
- Description
- Used to inhibit and study the mechanism of autophagy (lysosomal self-degradation) and apoptosis under various conditions. Inhibits autophagy by blocking autophagosome formation via the inhibition of type III Phosphatidylinositol 3-kinases (PI-3K).
- Smiles
- CN1C2=NC=NC2=C(N)N=C1
- InChi Key
- FSASIHFSFGAIJM-UHFFFAOYSA-N
- References
- (1) L.H. Caro, et al.: Eur. J. Biochem. 175, 325 (1988) , (2) E.L. Eskelinen, et al.: Traffic. 3, 878 (2002) , (3) A. Beugnet, et al.: Biochem. J. 372, 555 (2003) , (4) K. Hirosako, et al.: BBRC 316, 845 (2004) , (5) N. Canu, et al.: J. Neurochem. 92, 1228 (2005)
- InChi
- InChI=1S/C6H7N5/c1-11-3-10-5(7)4-6(11)9-2-8-4/h2-3H,7H2,1H3
Used to inhibit and study the mechanism of autophagy (lysosomal self-degradation) and apoptosis under various conditions. Inhibits autophagy by blocking autophagosome formation via the inhibition of type III Phosphatidylinositol 3-kinases (PI-3K).