Specifications
- Purity
- ≥99% (HPLC)
- Appearance
- Beige powder
- Identity
- 1H-NMR
Properties
- Solvents
- sodium hydroxide (10 mg/ml)
Downloads
- Safety Data Sheet
- CDX N0125 MSDS.pdf
Category: Non Fluorescent Detection & Chromogene Detection
Histochemical substrate for alkaline phosphatases. Aldolase inhibitor. Small molecule inhibitor. Anticancer compound that directly targets the KIX domain of CBP, resulting in a disrupted CREB-CBP complex, inhibited CREB-target gene induction and inhibited IL-1β-mediated angiogenic activity in cancer cell lines. Inhibits activity of transcription factor Myb by blocking interaction with KIX domain of coactivator p300 in human leukemia cells. Interferes with the Myb–KIX interaction in vitro and inhibits Myb activity in vivo. Suppresses the expression of Myb target genes and induces myeloid differentiation and apoptosis.
Synonyms | N-(4-Chlorophenyl)-3-(phosphonooxy)naphthalene-2-carboxamide, KG-501, NASEP |
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Purity | ≥99% (HPLC) |
Appearance | Beige powder |
CAS-Number | 18228-17-6 |
Molecular Formula | C17H13ClNO5P |
Molecular Weight | 377.72 |
Identity | 1H-NMR |
Solvents | sodium hydroxide (10 mg/ml) |
Smiles | ClC(C=C1)=CC=C1NC(C2=CC3=CC=CC=C3C=C2OP(O)(O)=O)=O |
InChi Key | RQAQWBFHPMSXKR-UHFFFAOYSA-N |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Transportation | Not dangerous goods |
References | (1) Z. Lojda, et al., Histochemie 11, 13 (1967), (2) J.L. Best, et al., PNAS 101, 17622 (2004), (3) M. St-Jean, et al., J. Biol. Chem. 282, 14309 (2007), (4) B.X. Li & X. Xiao, et al., ChemBioChem 10, 2721 (2009), (5) J.W. Lee, et al., PLoS One 10, e0122628 (2015), (6) S. Uttarkar, et al., Mol. Cancer Ther. 14, 1276 (2015) |
InChi | InChI=1S/C17H13ClNO5P/c18-13-5-7-14(8-6-13)19-17(20)15-9-11-3-1-2-4-12(11)10-16(15)24-25(21,22)23/h1-10H,(H,19,20)(H2,21,22,23) |
Quantity | 500 mg, 1 g, Bulk |