Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- Liquid
- Identity
- 1H-NMR
- Concentration
- 1.0 mg/ml in methanol
Properties
- Solvents
- aqueous buffers
Category: API's & Intermediates
Naproxen is a potent, non-steroidal, non-selective anti-inflammatory cyclooxygenase (COX-1 and COX-2) inhibitor. Inhibits COX-1 expression in HUVECS at a concentration of 5µg/ml. This COX inhibitor is indicated for the treatment of pain, fever, inflammation and stiffness. Research indicates that the S-naproxen is a more active form than the R-naproxen. The S-naproxen enantiomer was observed to inhibit platelet aggregation, and both enantiomers decrease production of thromboxane B2. Naproxen has been demonstrated to block Aβ fibril growth and form a complex with copper (II).
Synonyms | (S)-Naproxen, (+)-Naproxen, (S)-(+)-6-Methoxy-α-methyl-2-naphthalene acetic acid, Equiproxen, Laraflex |
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Purity | ≥98% (HPLC) |
Appearance | Liquid |
CAS-Number | 22204-53-1 |
Molecular Formula | C14H14O3 |
Molecular Weight | 230.26 |
Identity | 1H-NMR |
Solvents | aqueous buffers |
Smiles | C[C@H](C(O)=O)C1=CC2=CC=C(OC)C=C2C=C1 |
InChi Key | CMWTZPSULFXXJA-VIFPVBQESA-N |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | +4°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
Hazard statements | H225-H301 + H311 + H331-H370 |
Precautionary statements | P210-P260-P280-P301 + P310-P311 |
GHS Symbol | GHS02+GHS06 |
Signal word | Danger |
RIDADR | UN1230 3 |
Transportation | Packing Group III |
References | (1) W.F. Kean, et al., J. Pharm. Sci. 78, 324 (1989), (2) T. Zyglewska, et al., Biochim. Biophys. Acta 1131, 78 (1992), (3) J. Barnett, et al., Biochim. Biophys. Acta 1209, 130 (1994), (4) O. Laneuville, et al., J. Pharmacol. Exp. Ther. 271, 927 (1994), (5) N.M. Davies & K.E. Anderson, Clin. Pharmacokinet. 32, 268 (1997), (6) N. Monck, IDrugs 6, 593 (2003), (7) T. Takeda, et al., J. Phys. Chem. B. 114, 15394 (2010), (8) K.C. Duggan, et al., J. Biol. Chem. 285, 34950 (2010) |
InChi | InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16) |
Quantity | 5 ml, Bulk |
cdx-Concentration | 1.0 mg/ml in methanol |