Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- Yellow powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO (10 mg/ml), DMF
Downloads
- Safety Data Sheet
- CDX O0143 MSDS.pdf
Olanzapine is a 5-HT2 serotonin and D1/D2 dopamine receptor antagonist, that binds to dopamine D1, D2, and D4 receptors (Ki=31, 11, and 27 nM, respectively) as well as the serotonin (5-HT) receptor subtypes 5-HT2A, 5-HT2C and 5-HT3 (Ki=4, 11, and 57 nM, respectively). It also binds to M1 muscarinic acetylcholine, α1-adrenergic and histamine H1 receptors (Ki=2, 19, and 7 nM, respectively). Olanzapine is an atypical antipsychotic that displays anticholinergic properties. Olanzapine shows antidepressant-like activity. Formulations containing olanzapine have been used in the treatment of schizophrenia and bipolar disorder and for the prevention and treatment of chronic nausea and chemotherapy-induced nausea and vomiting.
Synonyms | 2-Methyl-4-(4-methyl-1-piperazinyl)- 10H-thieno[2,3-b][1,5]benzodiazepine, LY-170053 |
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Purity | ≥98% (HPLC) |
Appearance | Yellow powder |
CAS-Number | 132539-06-1 |
Molecular Formula | C17H20N4S |
Molecular Weight | 312.43 |
Identity | 1H-NMR |
Solvents | DMSO (10 mg/ml), DMF |
Smiles | CN1CCN(CC1)C1=NC2=CC=CC=C2NC2=C1C=C(C)S2 |
InChi Key | KVWDHTXUZHCGIO-UHFFFAOYSA-N |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | +4°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
Hazard statements | H315-H319-H413 |
Precautionary statements | P305 + P351 + P338 |
GHS Symbol | GHS07 |
Signal word | Warning |
Transportation | Not dangerous goods |
References | (1) N.A. Moore, et al., J. Pharmacol. Exp. Ther. 262, 545 (1992), (2) F.P. Bymaster, et al., Neuropsychopharmacol. 14, 87 (1996), (3) G.D. Tollefson & C.C. Taylor, CNS Drug Reviews 6, 303 (2000), (4) E. Nowakowska, et al., Pharmacol. Rep. 66, 404 (2014), (5) D.M. Ashby, et al., Behav. Pharmacol. 26, 133 (2015), (6) C. Fonte, et al., Crit. Rev. Oncol. Hematol. 95, 214 (2015) |
Quantity | 1 g, 5 g, Bulk |