Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White to pale yellow powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO (10 mg/ml), DMF (10 mg/ml), ethanol (0,5 mg/ml)
Downloads
- Safety Data Sheet
- CDX T0415 MSDS.pdf
Category: Phytochemicals
Tangeritin is a polymethoxylated flavone isolated from peels of citrus fruits with antiproliferative and antioxidant properties. It inhibits signaling in cancer cells, reducing ERK phosphorylation and growth of estradiol-stimulated T47D breast cancer cells and blocking p38 MAPK, JNK, and Akt activation in interleukin-1β-stimulated human lung carcinoma A549 cells. It is described to block cell cycle progression at G1 and induce apoptosis. Shows anti-inflammatory, osteoprotective and neuroprotective effects. Tangeritin activates the pregnane X receptor, inducing MDR1 expression in human colonic LS180 cancer cells. Shown to be a Notch-1 inhibitor. Tangeretin stimulates glucose uptake via regulation of AMPK signaling pathways and has been shown to antagonize ABCB1-mediated multidrug resistance.
Synonyms | 4',5,6,7,8-Pentamethoxyflavone, NSC 53909, NSC 618905, Ponkanetin, 5,6,7,8-Tetramethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one |
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Purity | ≥98% (HPLC) |
Appearance | White to pale yellow powder |
CAS-Number | 481-53-8 |
Molecular Formula | C20H20O7 |
Molecular Weight | 372.37 |
Identity | 1H-NMR |
Solvents | DMSO (10 mg/ml), DMF (10 mg/ml), ethanol (0,5 mg/ml) |
Smiles | O=C1C=C(C2=CC=C(OC)C=C2)OC3=C(OC)C(OC)=C(OC)C(OC)=C31 |
InChi Key | ULSUXBXHSYSGDT-UHFFFAOYSA-N |
Shipping | AMBIENT |
Short Term Storage | RT |
Long Term Storage | RT |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at RT. |
Hazard statements | H300 |
Precautionary statements | P264-P301 + P310 |
GHS Symbol | GHS06 |
Signal word | Danger |
RIDADR | 2811 6.1 |
Transportation | Packing Group III |
References | (1) T. Hirano, et al., Br. J. Cancer 72, 1380 (1995), (2) C. Chaumontet, et al., Cancer Lett. 114, 207 (1997), (3) S. Kawaii, et al., Biosci. Biotechnol. Biochem. 63, 896 (1999), (4) K.P. Datla, et al., Neuroreport 12, 3871 (2001), (5) M.H. Pan, et al., Carcinogenesis 23, 1677 (2002), (6) S. Van Slambrouck, et al., FEBS Lett. 579, 1665 (2005), (7) K.H. Chen, et al., Biochem. Pharmacol. 73, 215 (2007), (8) K.L. Morley, et al., Cancer Lett. 251, 168 (2007), (9) H. Satsu, et al., J. Agricult. Food Chem. 56, 5366 (2008), (10) M.S. Kim, et al., Mol. Cell Endocrinol. 358, 127 (2012), (11) Z. Shu, et al., Int. Immunopharmacol. 19, 275 (2014), (12) Y.Y. Lee, et al., J. Neuroimmune Pharmacol. 11, 294 (2016), (13) S.L. Feng, et al., Pharmacol. Res. 110, 193 (2016), (14) L.L. Ma, et al., Biomed. Pharmacother. 81, 491 (2016), (15) N. Braidy, et al., CNS Neurol. Disord. Drug Targets 16, 387 (2017) (Review), (16) S. Xu, et al., Int. Immunopharmacol. 72, 402 (2019) |
Quantity | 5 mg, 10 mg, Bulk |