Available from stock

1α-Hydroxyvitamin D3

SKU: H0262

Category: Vitamins

Synonyms: 1&alpha,-Hydroxycholecalciferol, Alfacalcidol, &alpha,-Calcidol, Etalpha, 1-hydroxy Cholecalciferol, Tevabone, Alpha D3, 1&alpha,-OH-D3; 41294-56-8
CAS-Number: C₂₇H₄₄O₂
Molecular Formula: 400.64
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥97% (HPLC)
Appearance: White to off-white powder

Properties

Solvents: Soluble in DMF (20 mg/ml), DMSO (20 mg/ml), ethanol (20 mg/ml).

Shipping: AMBIENT
Short Term Storage: -20°C
Long Term Storage: -20°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at -20°C.

Hazard statements: H300
Precautionary statements: P301 + P330 + P331 + P310
GHS Symbol: GHS06
Signal word: Danger
RIDADR: UN2811
Transportation: Packing Group I

Description: 1α-Hydroxyvitamin D3 is a synthetic analog of vitamin D used extensively in biomedical research and clinical studies for its potent calcium-regulating properties. Ths prodrug is rapidly converted by cytochrome P450 isoforms in the liver to the active metabolite 1α,25-dihydroxyvitamin D3, bypassing the need for renal 1α-hydroxylation. This makes it particularly valuable in studying calcium and phosphate homeostasis, bone metabolism, and the treatment of disorders like osteoporosis and chronic kidney disease-related mineral and bone disorder (CKD-MBD). 1α-Hydroxyvitamin D3 is a non-selective VDR activator and used to explore vitamin D receptor (VDR) signaling, immune modulation, and potential anti-inflammatory and anti-proliferative effects across various cell types. Compound can be used as analytical reference material.
Smiles: C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(C)C)([H])/C(CCC1)=C/C=C3C([C@H](C[C@@H](C\3)O)O)=C
InChi Key: OFHCOWSQAMBJIW-AVJTYSNKSA-N
References: (1) J.E. Zerwekh, et al., Biochem. 13, 4097 (1974) , (2) N. Takeshita, et al., Life Sci. 56, 1095 (1995) , (3) A. Shiraishi, et al., Calcif. Tissue Int. 65, 311 (1999) , (4) R.A. Upton, et al., Nephrol. Dial. Transplant 18, 750 (2003) , (5) R. Nuti, et al., Rheumatol. Int. 26, 445 (2006) , (6) R.C. Tuckey, et al., J. Steroid Biochem. Mol. Biol. 112, 213 (2008) , (7) N. Kubodera, Molecules 14, 3869 (2009) , (8) C.S. Ritter & A.J. Brown, J. Mol. Endocrinol. 46, 63 (2011) , (9) T. Suda, et al., Arch. Biochem. Biophys. 523, 22 (2012)
InChi: InChI=1S/C27H44O2/c1-18(2)8-6-9-19(3)24-13-14-25-21(10-7-15-27(24,25)5)11-12-22-16-23(28)17-26(29)20(22)4/h11-12,18-19,23-26,28-29H,4,6-10,13-17H2,1-3,5H3/b21-11+,22-12-/t19-,23-,24-,25+,26+,27-/m1/s1

1α-Hydroxyvitamin D3 is a synthetic analog of vitamin D used extensively in biomedical research and clinical studies for its potent calcium-regulating properties. Ths prodrug is rapidly converted by cytochrome P450 isoforms in the liver to the active metabolite 1α,25-dihydroxyvitamin D3, bypassing the need for renal 1α-hydroxylation. This makes it particularly valuable in studying calcium and phosphate homeostasis, bone metabolism, and the treatment of disorders like osteoporosis and chronic kidney disease-related mineral and bone disorder (CKD-MBD). 1α-Hydroxyvitamin D3 is a non-selective VDR activator and used to explore vitamin D receptor (VDR) signaling, immune modulation, and potential anti-inflammatory and anti-proliferative effects across various cell types. Compound can be used as analytical reference material.

SKU: H0262 Category: Vitamins

Additional information

Additional information

Synonyms	1&alpha,-Hydroxycholecalciferol, Alfacalcidol, &alpha,-Calcidol, Etalpha, 1-hydroxy Cholecalciferol, Tevabone, Alpha D3, 1&alpha,-OH-D3
Purity	≥97% (HPLC)
Appearance	White to off-white powder
CAS-Number	41294-56-8
Molecular Formula	C27H44O2
Molecular Weight	400.64
Solvents	Soluble in DMF (20 mg/ml), DMSO (20 mg/ml), ethanol (20 mg/ml).
Smiles	C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(C)C)([H])/C(CCC1)=C/C=C3C([C@H](C[C@@H](C\3)O)O)=C
InChi Key	OFHCOWSQAMBJIW-AVJTYSNKSA-N
Shipping	AMBIENT
Short Term Storage	-20°C
Long Term Storage	-20°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at -20°C.
Hazard statements	H300
Precautionary statements	P301 + P330 + P331 + P310
GHS Symbol	GHS06
Signal word	Danger
RIDADR	UN2811
Transportation	Packing Group I
References	(1) J.E. Zerwekh, et al., Biochem. 13, 4097 (1974), (2) N. Takeshita, et al., Life Sci. 56, 1095 (1995), (3) A. Shiraishi, et al., Calcif. Tissue Int. 65, 311 (1999), (4) R.A. Upton, et al., Nephrol. Dial. Transplant 18, 750 (2003), (5) R. Nuti, et al., Rheumatol. Int. 26, 445 (2006), (6) R.C. Tuckey, et al., J. Steroid Biochem. Mol. Biol. 112, 213 (2008), (7) N. Kubodera, Molecules 14, 3869 (2009), (8) C.S. Ritter & A.J. Brown, J. Mol. Endocrinol. 46, 63 (2011), (9) T. Suda, et al., Arch. Biochem. Biophys. 523, 22 (2012)
InChi	InChI=1S/C27H44O2/c1-18(2)8-6-9-19(3)24-13-14-25-21(10-7-15-27(24,25)5)11-12-22-16-23(28)17-26(29)20(22)4/h11-12,18-19,23-26,28-29H,4,6-10,13-17H2,1-3,5H3/b21-11+,22-12-/t19-,23-,24-,25+,26+,27-/m1/s1
Quantity	5 mg, 10 mg, 25 mg, Bulk