Specifications
- Purity
- ≥97% (NMR)
- Appearance
- White to off-white powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO (20mg/ml) or ethanol (20mg/ml)
- Melting Point
- 100 - 104 °C (lit.)
- Density
- 1.10
Documentation
- Safety Data Sheet (SDS)
- CDX P0147 MSDS.pdf
Available from stock
1,10-Phenanthroline monohydrate
- SKU
- P0147
Category: Non Fluorescent Detection & Chromogene Detection
- Synonyms
- o-Phenanthroline monohydrate, 4,5-Diazaphenanthrene monohydrate, ?-Phenanthroline monohydrate
- 5144-89-8
- CAS-Number
- C12H8N2 * H2O
- Molecular Formula
- 198.22
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- RT
- Long Term Storage
- RT
- Handling Advice
- Very hygroscopic. Store under inert gas.
- Use / Stability
- Stable for at least 2 years after receipt when stored at RT.
- Hazard statements
- H301 - H410
- Precautionary statements
- P264 - P273 - P301 + P310 - P391 - P405 - P501
- GHS Symbol
- GHS06+GHS09
- Signal word
- Danger
- RIDADR
- UN2811
- Transportation
- Packing Group III
- Description
- Hydrate form of 1,10-Phenanthroline. 1,10-Phenanthroline is a heterocyclic organic compound, which forms complexes with metal ions. It is a versatile ligand employed in the spectrophotometric determination of metals and photocatalytic reduction of carbon dioxide. The complexes that are build have wide applications in biochemistry, catalysis and analytical chemistry. 1,10-Phenanthroline is a ligand used in a mild, copper (II)-catalyzed cross-coupling of organoboronic acids and sulfinate salts leading to aryl- and alkenylsulfones. It is a conventional chelator to study its efficacy in Fenton?s reaction-luminol chemiluminescence system. 1,10-Phenanthroline enhances hPSC differentiation into cranial placode cells and is known as a non-specific matrix metalloproteinase (MMP) inhibitor. 1,10-Phenanthroline is also used as a building block for metallomacrocycles and other biological active compounds, such as anti-cancer agents.
- Smiles
- O.N=1C=CC=C2C=CC=3C=CC=NC3C12
- InChi Key
- PPQJCISYYXZCAE-UHFFFAOYSA-N
- References
- (1) G. Hoyer, et al., Scand. J. Clin. Lab Invest. 2, 125 (1950) , (2) M.M. Jones & D.O. Johnston, Nature 216, 509 (1967) , (3) K. Kobashi, Biochim. Biophys. Acta 158, 239 (1968) , (4) H.M. Butler, et al., Aust. J. Exp. Biol. Med. Sci. 47, 541 (1969) , (5) M. Kito & R. Urade, Met. Ions Biol. Syst. 38, 187 (2001) (Review) , (6) M. McCann, et al., Curr. Med. Chem. 19, 2703 (2012) (Review) , (7) J. Tchieu, et al., Cell Stem Cell 21, 399 (2017) , (8) N. Georgi, et al., J. Tissue Eng. Regen. Med. 11, 724 (2017) , (9) S. Masuri, et al., Molecules 27, 49 (2021) (Review) , (10) W.A. Souza, et al., J. Inorg. Biochem. 237, 111993 (2022) , (11) U. Bildziukevich, et al., Org. Biomol. Chem. 20, 8157 (2022) , (12) M.M. Cetin, et al., Front. Pharmacol. 13, 980479 (2022) , (13) N.A. Ashashi, et al., ACS Omega 7, 41370 (2022) , (14) D. Zhang, et al., Spectrochim. Acta A Mol. Biomol. Spectrosc. 295, 122608 (2023)
- InChi
- InChI=1S/C12H8N2.H2O/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1,/h1-8H,1H2
Hydrate form of 1,10-Phenanthroline. 1,10-Phenanthroline is a heterocyclic organic compound, which forms complexes with metal ions. It is a versatile ligand employed in the spectrophotometric determination of metals and photocatalytic reduction of carbon dioxide. The complexes that are build have wide applications in biochemistry, catalysis and analytical chemistry. 1,10-Phenanthroline is a ligand used in a mild, copper (II)-catalyzed cross-coupling of organoboronic acids and sulfinate salts leading to aryl- and alkenylsulfones. It is a conventional chelator to study its efficacy in Fenton?s reaction-luminol chemiluminescence system. 1,10-Phenanthroline enhances hPSC differentiation into cranial placode cells and is known as a non-specific matrix metalloproteinase (MMP) inhibitor. 1,10-Phenanthroline is also used as a building block for metallomacrocycles and other biological active compounds, such as anti-cancer agents.
Additional information
| Synonyms | o-Phenanthroline monohydrate, 4,5-Diazaphenanthrene monohydrate, ?-Phenanthroline monohydrate |
|---|---|
| Purity | ≥97% (NMR) |
| Appearance | White to off-white powder |
| CAS-Number | 5144-89-8 |
| Molecular Formula | C12H8N2 * H2O |
| Molecular Weight | 198.22 |
| Identity | 1H-NMR |
| Solvents | DMSO (20mg/ml) or ethanol (20mg/ml) |
| Melting Point | 100 – 104 °C (lit.) |
| Density | 1.10 |
| Smiles | O.N=1C=CC=C2C=CC=3C=CC=NC3C12 |
| InChi Key | PPQJCISYYXZCAE-UHFFFAOYSA-N |
| Shipping | AMBIENT |
| Short Term Storage | RT |
| Long Term Storage | RT |
| Handling Advice | Very hygroscopic. Store under inert gas. |
| Use / Stability | Stable for at least 2 years after receipt when stored at RT. |
| Hazard statements | H301 – H410 |
| Precautionary statements | P264 – P273 – P301 + P310 – P391 – P405 – P501 |
| GHS Symbol | GHS06+GHS09 |
| Signal word | Danger |
| RIDADR | UN2811 |
| Transportation | Packing Group III |
| References | (1) G. Hoyer, et al., Scand. J. Clin. Lab Invest. 2, 125 (1950), (2) M.M. Jones & D.O. Johnston, Nature 216, 509 (1967), (3) K. Kobashi, Biochim. Biophys. Acta 158, 239 (1968), (4) H.M. Butler, et al., Aust. J. Exp. Biol. Med. Sci. 47, 541 (1969), (5) M. Kito & R. Urade, Met. Ions Biol. Syst. 38, 187 (2001) (Review), (6) M. McCann, et al., Curr. Med. Chem. 19, 2703 (2012) (Review), (7) J. Tchieu, et al., Cell Stem Cell 21, 399 (2017), (8) N. Georgi, et al., J. Tissue Eng. Regen. Med. 11, 724 (2017), (9) S. Masuri, et al., Molecules 27, 49 (2021) (Review), (10) W.A. Souza, et al., J. Inorg. Biochem. 237, 111993 (2022), (11) U. Bildziukevich, et al., Org. Biomol. Chem. 20, 8157 (2022), (12) M.M. Cetin, et al., Front. Pharmacol. 13, 980479 (2022), (13) N.A. Ashashi, et al., ACS Omega 7, 41370 (2022), (14) D. Zhang, et al., Spectrochim. Acta A Mol. Biomol. Spectrosc. 295, 122608 (2023) |
| InChi | InChI=1S/C12H8N2.H2O/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1,/h1-8H,1H2 |
| Quantity | 5 g, 25 g, Bulk |
