3-Acetyl-11-keto-ß-boswellic acid

SKU: A0327

Category: Phytochemicals

Synonyms: AKBA , (3a,4β)-3-(Acetyloxy)-11-oxo Urs-12-en-23-oic Acid , 11-keto-β-boswellic Acid Acetate , 3-O-Acetyl-11-keto-β-boswellic Acid , 3a-Acetoxy-11-oxo-12-ursen-24-oic acid , 3a-Acetyl-11-keto-β-boswellic Acid , Acetyl-11-keto-β-boswellic Acid; 67416-61-9
CAS-Number: C₃₂H₄₈O₅
Molecular Formula: 512.72
Molecular Weight

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Identity: 1H-NMR
Appearance: White to off-white powder

Properties

Melting Point: ≥264°C (dec.)
Solvents: chloroform, methanol, DMSO (25 mg/ml), DMF (25 mg/ml), ethanol (5 mg/ml)

Shipping: AMBIENT
Use / Stability: Stable for at least 2 years after receipt when stored at +4°C.
Handling Advice: Protect from light and moisture.
Long Term Storage: +4°C
Short Term Storage: RT

Transportation: Not dangerous goods

Description: 3-Acetyl-11-keto-β-boswellic acid (AKBA) antitumor and anti-inflammatory activities. It is a potent non-redox, noncompetitive 5-lipoxygenase and topoisomerase I and IIa inhibitor leading to apoptosis. It exhibits in vivo efficacy in tumor growth inhibitio and has been studied for potential use in the control of inflammatory diseases, including arthritis and cancer.
References: (1) H. Safayhi, et al., J. Pharmacol. Exp. Ther. 261, 1143 (1992) , (2) R.F. Hoernlein, et al., J. Pharmacol. Exp. Ther. 288, 613 (1999) , (3) A. Altmann, et al., BBRC 290, 185 (2002) , (4) A. Altmann, et al., Br. J. Pharmacol. 141, 223 (2004) , (5) T. Syrovets, et al., J. Biol. Chem. 280, 6170 (2005) , (6) L. Xia, et al., Mol. Cancer Therap. 4, 381 (2005) , (7) M. Bishnoi, et al., Indian J. Exp. Biol. 44, 128 (2006) , (8) C. Anthoni, et al., Am. J. Physiol. Gastrointest. Liver Physiol. 290, G1131 (2006) , (9) D. Poeckel & O. Werz, Curr. Med. Chem. 13, 3359 (2006) (Review)
InChi Key: HMMGKOVEOFBCAU-BCDBGHSCSA-N
Smiles: O=C1[C@@]([C@](CC2)(C)[C@@]([C@@](C)(C(O)=O)[C@@H]2OC(C)=O)([H])CC3)([H])[C@]3(C)[C@@]4(C)C([C@@]([C@@H](C)[C@H](C)CC5)([H])[C@@]5(C)CC4)=C1

3-Acetyl-11-keto-β-boswellic acid (AKBA) antitumor and anti-inflammatory activities. It is a potent non-redox, noncompetitive 5-lipoxygenase and topoisomerase I and IIa inhibitor leading to apoptosis. It exhibits in vivo efficacy in tumor growth inhibitio and has been studied for potential use in the control of inflammatory diseases, including arthritis and cancer.

Artikelnummer: A0327 Kategorie: Phytochemicals

Zusätzliche Information

Zusätzliche Information

Synonyms	AKBA, (3a,4β)-3-(Acetyloxy)-11-oxo Urs-12-en-23-oic Acid, 11-keto-β-boswellic Acid Acetate, 3-O-Acetyl-11-keto-β-boswellic Acid, 3a-Acetoxy-11-oxo-12-ursen-24-oic acid, 3a-Acetyl-11-keto-β-boswellic Acid, Acetyl-11-keto-β-boswellic Acid
Purity	≥98% (HPLC)
Appearance	White to off-white powder
CAS-Number	67416-61-9
Molecular Formula	C32H48O5
Molecular Weight	512.72
Identity	1H-NMR
Solvents	chloroform, methanol, DMSO (25 mg/ml), DMF (25 mg/ml), ethanol (5 mg/ml)
Melting Point	≥264°C (dec.)
Smiles	O=C1[C@@]([C@](CC2)(C)[C@@]([C@@](C)(C(O)=O)[C@@H]2OC(C)=O)([H])CC3)([H])[C@]3(C)[C@@]4(C)C([C@@]([C@@H](C)[C@H](C)CC5)([H])[C@@]5(C)CC4)=C1
InChi Key	HMMGKOVEOFBCAU-BCDBGHSCSA-N
Shipping	AMBIENT
Short Term Storage	RT
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at +4°C.
Transportation	Not dangerous goods
References	(1) H. Safayhi, et al., J. Pharmacol. Exp. Ther. 261, 1143 (1992), (2) R.F. Hoernlein, et al., J. Pharmacol. Exp. Ther. 288, 613 (1999), (3) A. Altmann, et al., BBRC 290, 185 (2002), (4) A. Altmann, et al., Br. J. Pharmacol. 141, 223 (2004), (5) T. Syrovets, et al., J. Biol. Chem. 280, 6170 (2005), (6) L. Xia, et al., Mol. Cancer Therap. 4, 381 (2005), (7) M. Bishnoi, et al., Indian J. Exp. Biol. 44, 128 (2006), (8) C. Anthoni, et al., Am. J. Physiol. Gastrointest. Liver Physiol. 290, G1131 (2006), (9) D. Poeckel & O. Werz, Curr. Med. Chem. 13, 3359 (2006) (Review)
Quantity	5 mg, Bulk