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5-Hydroxy-L-tryptophan

SKU: H0160

Category: Metabolites

Synonyms: Oxitriptan , 5-HTP , L-2-Amino-3-(5-hydroxyindolyl)propionic acid , L-5-HTTP , L-5-Hydroxytryptophan; 4350-09-8
CAS-Number: C₁₁H₁₂N₂O₃
Molecular Formula: 220.22
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥99% (HPLC)
Appearance: Off-white powder
Identity: 1H-NMR

Properties

Solvents: water (10 mg/ml), chloroform, DMSO
Melting Point: 270° C

Shipping: AMBIENT
Short Term Storage: +4°C
Long Term Storage: +4°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at +4°C.

Hazard statements: H301
Precautionary statements: P264 - P270 - P301 + P310 - P405 - P501
GHS Symbol: GHS06
Signal word: Danger
RIDADR: UN2811
Transportation: Packing Group III

Description: 5-hydroxy-L-Tryptophan (5-HTP), also known as oxitriptan, is a naturally occurring amino acid and chemical precursor as well as a metabolic intermediate in the biosynthesis of the neurotransmitter serotonin. It is used as a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid. It is also used as L-aromatic amino acid decarboxylase substrate. When injected systemically in animals, 5-HTP is converted to serotonin and has both peripheral and central nervous system effects. 5-HTP can also be synthesized by gut microbiota and acts as an activator of the aryl hydrocarbon receptor.
Smiles: OC1=CC=C(NC=C2C[C@H](N)C(O)=O)C2=C1
InChi Key: LDCYZAJDBXYCGN-VIFPVBQESA-N
References: (1) A. Carlsson, et al., Nature 180, 1200 (1957) , (2) A. Boiardi, et al., J. Neurol. 225, 41 (1981) , (3) T.C. Birdsall, Altern. Med. Rev. 3, 271 (1998) , (4) A. Martinez, et al., Curr. Med. Chem. 8, 1077 (2001) , (5) E.H. Turner, et al., Pharmacol. Ther. 109, 325 (2006) , (6) C.L. Schmid & L.M. Bohn, J. Neurosci. 30, 13513 (2010) , (7) G.V. Sridharan, et al., Nat. Commun. 5, 5492 (2014) , (8) R. Haberzettl, et al., Behav. Brain Res. 277, 204 (2015) , (9) J.-A. Mora-Villalobos & A.-P. Zeng, J. Biol. Eng. 12, 3 (2018)

5-hydroxy-L-Tryptophan (5-HTP), also known as oxitriptan, is a naturally occurring amino acid and chemical precursor as well as a metabolic intermediate in the biosynthesis of the neurotransmitter serotonin. It is used as a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid. It is also used as L-aromatic amino acid decarboxylase substrate. When injected systemically in animals, 5-HTP is converted to serotonin and has both peripheral and central nervous system effects. 5-HTP can also be synthesized by gut microbiota and acts as an activator of the aryl hydrocarbon receptor.

SKU: H0160 Category: Metabolites

Additional information

Additional information

Synonyms	Oxitriptan, 5-HTP, L-2-Amino-3-(5-hydroxyindolyl)propionic acid, L-5-HTTP, L-5-Hydroxytryptophan
Purity	≥99% (HPLC)
Appearance	Off-white powder
CAS-Number	4350-09-8
Molecular Formula	C11H12N2O3
Molecular Weight	220.22
Identity	1H-NMR
Solvents	water (10 mg/ml), chloroform, DMSO
Melting Point	270° C
Smiles	OC1=CC=C(NC=C2C[C@H](N)C(O)=O)C2=C1
InChi Key	LDCYZAJDBXYCGN-VIFPVBQESA-N
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at +4°C.
Hazard statements	H301
Precautionary statements	P264 – P270 – P301 + P310 – P405 – P501
GHS Symbol	GHS06
Signal word	Danger
RIDADR	UN2811
Transportation	Packing Group III
References	(1) A. Carlsson, et al., Nature 180, 1200 (1957), (2) A. Boiardi, et al., J. Neurol. 225, 41 (1981), (3) T.C. Birdsall, Altern. Med. Rev. 3, 271 (1998), (4) A. Martinez, et al., Curr. Med. Chem. 8, 1077 (2001), (5) E.H. Turner, et al., Pharmacol. Ther. 109, 325 (2006), (6) C.L. Schmid & L.M. Bohn, J. Neurosci. 30, 13513 (2010), (7) G.V. Sridharan, et al., Nat. Commun. 5, 5492 (2014), (8) R. Haberzettl, et al., Behav. Brain Res. 277, 204 (2015), (9) J.-A. Mora-Villalobos & A.-P. Zeng, J. Biol. Eng. 12, 3 (2018)
Quantity	1 g, 5 g, 25 g, Bulk