Specifications
- Purity
- ≥95% (NMR)
- Appearance
- Light orange solid
- Identity
- 1H-NMR
Properties
- Solvents
- Soluble in DMSO or chloroform.
- Melting Point
- 66-68°C (lit.)
Available from stock
7-Fluoro-2,1,3- benzoxadiazole-4-sulfonylchloride
- SKU
- F0577
Category: Fluorescent Detection
- Synonyms
- CBD-F, 4-(Chlorosulfonyl)-7-fluoro-2,1,3-benzoxadiazole
- 91366-64-2
- CAS-Number
- C6H2ClFN2O3S
- Molecular Formula
- 236.61
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- +4°C
- Long Term Storage
- -20°C
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at -20°C.
- Hazard statements
- H314, H318
- Precautionary statements
- P280, P303+P361+P353, P305+P351+P338
- GHS Symbol
- GHS05
- Signal word
- Danger
- RIDADR
- UN3261
- Transportation
- Packing Group II
- Description
- 4-(Chlorosulfonyl)-7-fluoro-2,1,3-benzoxadiazole is a versatile nucleophilic intermediate or building block for the synthesis of thiol-reactive fluorogenic probes, like ADB-F, SBD-F or DBD-F. It is characterized by its unique chlorosulfonyl group that enhances electrophilic reactivity. The presence of the fluorine atom increases the compound's polarity, promoting strong dipole interactions. This compound exhibits rapid reaction kinetics, particularly in nucleophilic substitution reactions, making it an intriguing subject for exploring mechanistic pathways and reactivity profiles in synthetic chemistry.
- Smiles
- FC1=CC=C(S(=O)(Cl)=O)C2=NON=C21
- InChi Key
- ULAADSMIEGGGMT-UHFFFAOYSA-N
- References
- (1) T. Toyo'oka & K. Imai; Anal. Chem. 56, 2461 (1984) , (2) T. Toyo'oka, et al.; Analyst 114, 413 (1989) , (3) T. Toyo'oka, et al.; Analyst 114, 1233 (1989) , (4) T. Kajiro, et al.; Analyst 125, 1115 (2000) , (5) K. Okabe, et al.; J. Chromatogr. A 982, 111 (2002)
- InChi
- InChI=1S/C6H2ClFN2O3S/c7-14(11,12)4-2-1-3(8)5-6(4)10-13-9-5/h1-2H
4-(Chlorosulfonyl)-7-fluoro-2,1,3-benzoxadiazole is a versatile nucleophilic intermediate or building block for the synthesis of thiol-reactive fluorogenic probes, like ADB-F, SBD-F or DBD-F. It is characterized by its unique chlorosulfonyl group that enhances electrophilic reactivity. The presence of the fluorine atom increases the compound’s polarity, promoting strong dipole interactions. This compound exhibits rapid reaction kinetics, particularly in nucleophilic substitution reactions, making it an intriguing subject for exploring mechanistic pathways and reactivity profiles in synthetic chemistry.
Additional information
| Synonyms | CBD-F, 4-(Chlorosulfonyl)-7-fluoro-2,1,3-benzoxadiazole |
|---|---|
| Purity | ≥95% (NMR) |
| Appearance | Light orange solid |
| CAS-Number | 91366-64-2 |
| Molecular Formula | C6H2ClFN2O3S |
| Molecular Weight | 236.61 |
| Identity | 1H-NMR |
| Solvents | Soluble in DMSO or chloroform. |
| Melting Point | 66-68°C (lit.) |
| Smiles | FC1=CC=C(S(=O)(Cl)=O)C2=NON=C21 |
| InChi Key | ULAADSMIEGGGMT-UHFFFAOYSA-N |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Hazard statements | H314, H318 |
| Precautionary statements | P280, P303+P361+P353, P305+P351+P338 |
| GHS Symbol | GHS05 |
| Signal word | Danger |
| RIDADR | UN3261 |
| Transportation | Packing Group II |
| References | (1) T. Toyo'oka & K. Imai; Anal. Chem. 56, 2461 (1984), (2) T. Toyo'oka, et al.; Analyst 114, 413 (1989), (3) T. Toyo'oka, et al.; Analyst 114, 1233 (1989), (4) T. Kajiro, et al.; Analyst 125, 1115 (2000), (5) K. Okabe, et al.; J. Chromatogr. A 982, 111 (2002) |
| InChi | InChI=1S/C6H2ClFN2O3S/c7-14(11,12)4-2-1-3(8)5-6(4)10-13-9-5/h1-2H |
| Quantity | 25 mg, 100 mg, Bulk |
