Specifications
- Purity
- ≥98% (HPLC)
- Identity
- 1H-NMR
- Appearance
- White powder
Properties
- Solvents
- ethanol (20 mg/ml), DMSO (5 mg/ml), PBS, pH72 (10 mg/ml)
Available from stock
Amorolfine hydrochloride
- SKU
- A0301
Category: Antibiotics
- Synonyms
- Amorolfin , (2R,6S)-rel-4-[3-[4-(1,1-Dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-morpholine hydrochloride
- 78613-38-4
- CAS-Number
- C21H35ON . HCl
- Molecular Formula
- 317.51 . 36.46
- Molecular Weight
- Use / Stability
- Stable for at least 2 years after receipt when stored at RT.
- Handling Advice
- Protect from light and moisture.
- Long Term Storage
- RT
- Short Term Storage
- RT
- Shipping
- AMBIENT
- Transportation
- Packing Group III
- RIDADR
- UN3077
- Signal word
- Warning
- GHS Symbol
- GHS07+GHS09
- Precautionary statements
- P273
- Hazard statements
- H302-H315-H411
- Description
- Amorolfine (or amorolfin), is a morpholine antifungal drug that inhibits D14-sterol reductase and cholestenol D7-D8 isomerase, consequently depleting ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membranes in vivo. It acts primarily by inhibiting ergosterol biosynthesis, a component of fungal cell membrane, and possesses both fungistatic and fungicidal activity. Its spectrum of in vitro activity includes dermatophyte, dimorphic, dematiaceous and filamentous fungi and some yeasts.
- InChi
- InChI=1S/C21H35NO.ClH/c1-7-21(5,6)20-10-8-19(9-11-20)12-16(2)13-22-14-17(3)23-18(4)15-22,/h8-11,16-18H,7,12-15H2,1-6H3,1H/t16?,17-,18+,
- References
- (1) T. Hiratani, et al., Jpn. J. Antibiot. 44, 993 (1991) , (2) A. Polak, Dermatology 184, 3 (1992) , (3) M. Haria & H.M. Bryson, Drugs 49, 103 (1995) , (4) C. Flagothier, et al., Mycoses 48, 91 (2005) (Review)
- InChi Key
- XZKWIPVTHGWDCF-KUZYQSSXSA-N
- Smiles
- C[C@H]1C[NH+](CC(C)CC2=CC=C(C(C)(C)CC)C=C2)C[C@@H](C)O1.[Cl-]
Amorolfine (or amorolfin), is a morpholine antifungal drug that inhibits D14-sterol reductase and cholestenol D7-D8 isomerase, consequently depleting ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membranes in vivo. It acts primarily by inhibiting ergosterol biosynthesis, a component of fungal cell membrane, and possesses both fungistatic and fungicidal activity. Its spectrum of in vitro activity includes dermatophyte, dimorphic, dematiaceous and filamentous fungi and some yeasts.
Zusätzliche Information
| Synonyms | Amorolfin, (2R,6S)-rel-4-[3-[4-(1,1-Dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-morpholine hydrochloride |
|---|---|
| Purity | ≥98% (HPLC) |
| Appearance | White powder |
| CAS-Number | 78613-38-4 |
| Molecular Formula | C21H35ON . HCl |
| Molecular Weight | 317.51 . 36.46 |
| Identity | 1H-NMR |
| Solvents | ethanol (20 mg/ml), DMSO (5 mg/ml), PBS, pH72 (10 mg/ml) |
| Smiles | C[C@H]1C[NH+](CC(C)CC2=CC=C(C(C)(C)CC)C=C2)C[C@@H](C)O1.[Cl-] |
| InChi Key | XZKWIPVTHGWDCF-KUZYQSSXSA-N |
| Shipping | AMBIENT |
| Short Term Storage | RT |
| Long Term Storage | RT |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at RT. |
| Hazard statements | H302-H315-H411 |
| Precautionary statements | P273 |
| GHS Symbol | GHS07+GHS09 |
| Signal word | Warning |
| RIDADR | UN3077 |
| Transportation | Packing Group III |
| References | (1) T. Hiratani, et al., Jpn. J. Antibiot. 44, 993 (1991), (2) A. Polak, Dermatology 184, 3 (1992), (3) M. Haria & H.M. Bryson, Drugs 49, 103 (1995), (4) C. Flagothier, et al., Mycoses 48, 91 (2005) (Review) |
| InChi | InChI=1S/C21H35NO.ClH/c1-7-21(5,6)20-10-8-19(9-11-20)12-16(2)13-22-14-17(3)23-18(4)15-22,/h8-11,16-18H,7,12-15H2,1-6H3,1H/t16?,17-,18+, |
| Quantity | 250 mg, 500 mg, Bulk |
