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    Amorolfine hydrochloride

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      Amorolfine hydrochloride

      SKU
      A0301

      Category: Antibiotics

      Synonyms
      Amorolfin , (2R,6S)-rel-4-[3-[4-(1,1-Dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-morpholine hydrochloride
      78613-38-4
      CAS-Number
      C21H35ON . HCl
      Molecular Formula
      317.51 . 36.46
      Molecular Weight

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥98% (HPLC)
      Identity
      1H-NMR
      Appearance
      White powder

      Properties

      Solvents
      ethanol (20 mg/ml), DMSO (5 mg/ml), PBS, pH72 (10 mg/ml)
      Use / Stability
      Stable for at least 2 years after receipt when stored at RT.
      Handling Advice
      Protect from light and moisture.
      Long Term Storage
      RT
      Short Term Storage
      RT
      Shipping
      AMBIENT
      Transportation
      Packing Group III
      RIDADR
      UN3077
      Signal word
      Warning
      GHS Symbol
      GHS07+GHS09
      Precautionary statements
      P273
      Hazard statements
      H302-H315-H411
      Description
      Amorolfine (or amorolfin), is a morpholine antifungal drug that inhibits D14-sterol reductase and cholestenol D7-D8 isomerase, consequently depleting ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membranes in vivo. It acts primarily by inhibiting ergosterol biosynthesis, a component of fungal cell membrane, and possesses both fungistatic and fungicidal activity. Its spectrum of in vitro activity includes dermatophyte, dimorphic, dematiaceous and filamentous fungi and some yeasts.
      InChi
      InChI=1S/C21H35NO.ClH/c1-7-21(5,6)20-10-8-19(9-11-20)12-16(2)13-22-14-17(3)23-18(4)15-22,/h8-11,16-18H,7,12-15H2,1-6H3,1H/t16?,17-,18+,
      References
      (1) T. Hiratani, et al., Jpn. J. Antibiot. 44, 993 (1991) , (2) A. Polak, Dermatology 184, 3 (1992) , (3) M. Haria & H.M. Bryson, Drugs 49, 103 (1995) , (4) C. Flagothier, et al., Mycoses 48, 91 (2005) (Review)
      InChi Key
      XZKWIPVTHGWDCF-KUZYQSSXSA-N
      Smiles
      C[C@H]1C[NH+](CC(C)CC2=CC=C(C(C)(C)CC)C=C2)C[C@@H](C)O1.[Cl-]

      Amorolfine (or amorolfin), is a morpholine antifungal drug that inhibits D14-sterol reductase and cholestenol D7-D8 isomerase, consequently depleting ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membranes in vivo. It acts primarily by inhibiting ergosterol biosynthesis, a component of fungal cell membrane, and possesses both fungistatic and fungicidal activity. Its spectrum of in vitro activity includes dermatophyte, dimorphic, dematiaceous and filamentous fungi and some yeasts.

      Artikelnummer: A0301 Kategorie: Antibiotics
      • Zusätzliche Information

      Zusätzliche Information

      Synonyms

      Amorolfin, (2R,6S)-rel-4-[3-[4-(1,1-Dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-morpholine hydrochloride

      Purity

      ≥98% (HPLC)

      Appearance

      White powder

      CAS-Number

      78613-38-4

      Molecular Formula

      C21H35ON . HCl

      Molecular Weight

      317.51 . 36.46

      Identity

      1H-NMR

      Solvents

      ethanol (20 mg/ml), DMSO (5 mg/ml), PBS, pH72 (10 mg/ml)

      Smiles

      C[C@H]1C[NH+](CC(C)CC2=CC=C(C(C)(C)CC)C=C2)C[C@@H](C)O1.[Cl-]

      InChi Key

      XZKWIPVTHGWDCF-KUZYQSSXSA-N

      Shipping

      AMBIENT

      Short Term Storage

      RT

      Long Term Storage

      RT

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at RT.

      Hazard statements

      H302-H315-H411

      Precautionary statements

      P273

      GHS Symbol

      GHS07+GHS09

      Signal word

      Warning

      RIDADR

      UN3077

      Transportation

      Packing Group III

      References

      (1) T. Hiratani, et al., Jpn. J. Antibiot. 44, 993 (1991), (2) A. Polak, Dermatology 184, 3 (1992), (3) M. Haria & H.M. Bryson, Drugs 49, 103 (1995), (4) C. Flagothier, et al., Mycoses 48, 91 (2005) (Review)

      InChi

      InChI=1S/C21H35NO.ClH/c1-7-21(5,6)20-10-8-19(9-11-20)12-16(2)13-22-14-17(3)23-18(4)15-22,/h8-11,16-18H,7,12-15H2,1-6H3,1H/t16?,17-,18+,

      Quantity

      250 mg, 500 mg, Bulk

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