Specifications
- Purity
- ≥98% (TLC)
- Appearance
- Yellow to orange powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO, methanol, ethanol or water (slightly)
- Melting Point
- 214 °C
Documentation
- Safety Data Sheet (SDS)
- CDX B0212 MSDS.pdf
Available from stock
Berberine chloride
- SKU
- B0212
Category: Phytochemicals
- Synonyms
- Natural Yellow 18 , Berberinium chloride , BBR , Umbellatine
- 633-65-8
- CAS-Number
- C20H17NO4 . HCl
- Molecular Formula
- 371.81
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- +4°C
- Long Term Storage
- +4°C
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at +4°C.
- Transportation
- Not dangerous goods
- Description
- Natural fluorescent dye, used in histology for staining heparin in mast cells. An isoquinoline alkaloid, which shows antibacterial, antifungal, anti-inflammatory, anti-oxidant, antidiabetics, antiviral and anticancer activity. It inhibits cell growth and induces apoptosis in a variety of cancer cell lines. Broad spectrum enzyme inhibitor, affects N-acetyltransferase, cyclooxygenase-2, and topoisomerase activities and gene/protein expression. Increases adiponectin expression, upregulates LDLR and insulin receptor. Anti-hyperglycemic, by inhibition of aldose reductase, inducing glycolysis, preventing insulin resistance through increasing insulin receptor expression and acting like incretins. Activates AMPK and ERK.
- Smiles
- COC1=C(OC)C=CC2=CC(C3=CC4=C(OCO4)C=C3CC5)=[N+]5C=C12.[Cl-]
- InChi Key
- VKJGBAJNNALVAV-UHFFFAOYSA-M
- References
- (1) P.J. Kaboli, et al.: Eur. J. Pharmacol. 740, 584 (2014) , (2) L.M. Ortiz, et al.: Molecules 19, 12349 (2014) , (3) W.J. Ni, et al.: Eur. J. Pharmacol. 760, 103 (2015)
- InChi
- InChI=1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2
Natural fluorescent dye, used in histology for staining heparin in mast cells. An isoquinoline alkaloid, which shows antibacterial, antifungal, anti-inflammatory, anti-oxidant, antidiabetics, antiviral and anticancer activity. It inhibits cell growth and induces apoptosis in a variety of cancer cell lines. Broad spectrum enzyme inhibitor, affects N-acetyltransferase, cyclooxygenase-2, and topoisomerase activities and gene/protein expression. Increases adiponectin expression, upregulates LDLR and insulin receptor. Anti-hyperglycemic, by inhibition of aldose reductase, inducing glycolysis, preventing insulin resistance through increasing insulin receptor expression and acting like incretins. Activates AMPK and ERK.
Additional information
| Synonyms | Natural Yellow 18, Berberinium chloride, BBR, Umbellatine |
|---|---|
| Purity | ≥98% (TLC) |
| Appearance | Yellow to orange powder |
| CAS-Number | 633-65-8 |
| Molecular Formula | C20H17NO4 . HCl |
| Molecular Weight | 371.81 |
| Identity | 1H-NMR |
| Solvents | DMSO, methanol, ethanol or water (slightly) |
| Melting Point | 214 °C |
| Smiles | COC1=C(OC)C=CC2=CC(C3=CC4=C(OCO4)C=C3CC5)=[N+]5C=C12.[Cl-] |
| InChi Key | VKJGBAJNNALVAV-UHFFFAOYSA-M |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Transportation | Not dangerous goods |
| References | (1) P.J. Kaboli, et al.: Eur. J. Pharmacol. 740, 584 (2014), (2) L.M. Ortiz, et al.: Molecules 19, 12349 (2014), (3) W.J. Ni, et al.: Eur. J. Pharmacol. 760, 103 (2015) |
| InChi | InChI=1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2 |
| Quantity | 10 g, 25 g, 50 g, Bulk |
