beta-Nicotinamide adenine dinucleotide phosphate sodium salt hydrate

Available from stock

beta-Nicotinamide adenine dinucleotide phosphate sodium salt hydrate

SKU
N0151

Category:

Synonyms
Coenzyme II , β-NADP , NADP+ , TPN , Triphosphopyridine nucleotide sodium salt hydrate
698999-85-8
CAS-Number
C21H27N7NaO17P3 . xH2O
Molecular Formula
765.39 (anhydrous)
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Specifications

Purity
≥98% (HPLC)
Appearance
White to off-white powder
Identity
1H-NMR

Properties

Solvents
water (30 mg/ml)
Shipping
AMBIENT
Short Term Storage
+4°C
Long Term Storage
-20°C
Handling Advice
Protect from light and moisture.
Use / Stability
Stable for at least 2 years after receipt when stored at -20°C.
Hazard statements
H319
Precautionary statements
P280-P305 + P351 + P338-P337 + P313
GHS Symbol
GHS07
Signal word
Warning
Transportation
Not dangerous goods
Description
NADP+ is the oxidized form of the electron donor nicotinamide adenine dinucleotide phosphate. It is a cofactor used in anabolic reactions, such as the Calvin cycle, lipid syntheses and nucleic acid syntheses, which require NADPH as a reducing agent. It serves as a cofactor in various biological reactions. In addition, the balance between these reduced and oxidized forms plays key roles in diverse cellular functions, including cell survival, the maintenance of redox status and intracellular signaling. For example, binding of NADP+ to β-subunits of Kv channels activates ion transport, whereas NADPH stabilizes channel inactivation. NADP+ is biosynthesized from NAD+ by NAD kinase, with ATP as the phosphoryl donor. NADP+ might be useful for immunometabolism research.
Smiles
O[C@H]1[C@@H](OP(O)(O)=O)[C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1COP([O-])(OP(OC[C@@H]4[C@@H](O)[C@@H](O)[C@H]([N+]5=CC(C(N)=O)=CC=C5)O4)([O-])=O)=O.[Na+]
InChi Key
JNUMDLCHLVUHFS-QYZPTAICSA-M
References
(1) F. Shi, et al., Acta Biochim. Biophys. Sin. 41, 352 (2009) , (2) J.B. Jackson, BBA 1817, 1839 (2012) , (3) M. Nakamura, et al., Circ. Res. 111, 604 (2012) , (4) P.J. Kilfoil, et al., Circ. Res. 112, 721 (2013) , (5) M. Ziegler, FEBS J. 272, 4561 (2014) , (6) R. Ramalho, et al., Sem. Immunopathol. 42, 279 (2020)
InChi
InChI=1S/C21H28N7O17P3.Na/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32,/h1-4,7-8,10-11,13-16,20-21,29-31H,5-6H2,(H7-,22,23,24,25,32,33,34,35,36,37,38,39),/q,+1/p-1/t10-,11-,13-,14-,15-,16-,20-,21-,/m1./s1

NADP+ is the oxidized form of the electron donor nicotinamide adenine dinucleotide phosphate. It is a cofactor used in anabolic reactions, such as the Calvin cycle, lipid syntheses and nucleic acid syntheses, which require NADPH as a reducing agent. It serves as a cofactor in various biological reactions. In addition, the balance between these reduced and oxidized forms plays key roles in diverse cellular functions, including cell survival, the maintenance of redox status and intracellular signaling. For example, binding of NADP+ to β-subunits of Kv channels activates ion transport, whereas NADPH stabilizes channel inactivation. NADP+ is biosynthesized from NAD+ by NAD kinase, with ATP as the phosphoryl donor. NADP+ might be useful for immunometabolism research.

Artikelnummer: N0151 Kategorie:

Zusätzliche Informationen

Synonyms

Coenzyme II, β-NADP, NADP+, TPN, Triphosphopyridine nucleotide sodium salt hydrate
Purity

≥98% (HPLC)
Appearance

White to off-white powder
CAS-Number

698999-85-8
Molecular Formula

C21H27N7NaO17P3 . xH2O
Molecular Weight

765.39 (anhydrous)
Identity

1H-NMR
Solvents

water (30 mg/ml)
Smiles

O[C@H]1[C@@H](OP(O)(O)=O)[C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1COP([O-])(OP(OC[C@@H]4[C@@H](O)[C@@H](O)[C@H]([N+]5=CC(C(N)=O)=CC=C5)O4)([O-])=O)=O.[Na+]
InChi Key

JNUMDLCHLVUHFS-QYZPTAICSA-M
Shipping

AMBIENT
Short Term Storage

+4°C
Long Term Storage

-20°C
Handling Advice

Protect from light and moisture.
Use / Stability

Stable for at least 2 years after receipt when stored at -20°C.
Hazard statements

H319
Precautionary statements

P280-P305 + P351 + P338-P337 + P313
GHS Symbol

GHS07
Signal word

Warning
Transportation

Not dangerous goods
References

(1) F. Shi, et al., Acta Biochim. Biophys. Sin. 41, 352 (2009), (2) J.B. Jackson, BBA 1817, 1839 (2012), (3) M. Nakamura, et al., Circ. Res. 111, 604 (2012), (4) P.J. Kilfoil, et al., Circ. Res. 112, 721 (2013), (5) M. Ziegler, FEBS J. 272, 4561 (2014), (6) R. Ramalho, et al., Sem. Immunopathol. 42, 279 (2020)
InChi

InChI=1S/C21H28N7O17P3.Na/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32,/h1-4,7-8,10-11,13-16,20-21,29-31H,5-6H2,(H7-,22,23,24,25,32,33,34,35,36,37,38,39),/q,+1/p-1/t10-,11-,13-,14-,15-,16-,20-,21-,/m1./s1
Quantity

500 mg, 1 g, Bulk

Ähnliche Produkte

MyricetinMyricetinOnoninOnonin