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    Brinzolamide

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      Brinzolamide

      SKU
      B0424

      Category: API's & Intermediates

      Synonyms
      (R)-4-(Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide , AL 4862 , Azopt
      138890-62-7
      CAS-Number
      C12H21N3O5S3
      Molecular Formula
      383.51
      Molecular Weight

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥98% (HPLC)
      Identity
      1H-NMR
      Appearance
      White to beige powder

      Properties

      Solvents
      DMSO (30mg/ml), water or ethanol (insoluble)
      Short Term Storage
      -20°C
      Use / Stability
      Stable for at least 2 years after receipt when stored at -20°C.
      Handling Advice
      Protect from light and moisture.
      Long Term Storage
      -20°C
      Shipping
      AMBIENT
      Transportation
      Not dangerous goods
      Description
      Brinzolamide is a potent inhibitor of carbonic anhydrases (IC50=3.2nM and 45.3nM for CAII and CAIV, respectively) that lowers intraocular pressure by locally inhibiting carbonic anhydrase in the ciliary processes and suppressing aqueous humor secretion. Animal studies have found that one week of twice-daily topical ocular treatment with 2% brinzolamide significantly reduced IOP and enhanced optic nerve head blood flow.
      References
      (1) T. Stams, et al., Protein Science 7, 556 (1998) , (2) P.A. Boriack-Sjodin, et al., Protein Science 7, 2483 (1998) , (3) C.J. Ingram & R.F. Brubaker, Am. J. Ophthalmol. 128, 292 (1999) , (4) G.E. Barnes, et al., Survey of Ophthalmol. 44, S131 (2012) , (5) H. Zheng & B. Lou, Acta Crystallogr. E Crystallogr. Commun. 72, 692 (2016) , (6) T. Nakano, et al., Adv. Ther. 33, 1452 (2016) , (7) Y.R. Dong, et al., Int. J. Ophthalmol. 11, 719 (2018)
      InChi Key
      HCRKCZRJWPKOAR-JTQLQIEISA-N
      Smiles
      O=S(C1=CC2=C(S1)S(N(CCCOC)C[C@@H]2NCC)(=O)=O)(N)=O

      Brinzolamide is a potent inhibitor of carbonic anhydrases (IC50=3.2nM and 45.3nM for CAII and CAIV, respectively) that lowers intraocular pressure by locally inhibiting carbonic anhydrase in the ciliary processes and suppressing aqueous humor secretion. Animal studies have found that one week of twice-daily topical ocular treatment with 2% brinzolamide significantly reduced IOP and enhanced optic nerve head blood flow.

      Artikelnummer: B0424 Kategorie: API's & Intermediates
      • Zusätzliche Information

      Zusätzliche Information

      Synonyms

      (R)-4-(Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide, AL 4862, Azopt

      Purity

      ≥98% (HPLC)

      Appearance

      White to beige powder

      CAS-Number

      138890-62-7

      Molecular Formula

      C12H21N3O5S3

      Molecular Weight

      383.51

      Identity

      1H-NMR

      Solvents

      DMSO (30mg/ml), water or ethanol (insoluble)

      Smiles

      O=S(C1=CC2=C(S1)S(N(CCCOC)C[C@@H]2NCC)(=O)=O)(N)=O

      InChi Key

      HCRKCZRJWPKOAR-JTQLQIEISA-N

      Shipping

      AMBIENT

      Short Term Storage

      -20°C

      Long Term Storage

      -20°C

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at -20°C.

      Transportation

      Not dangerous goods

      References

      (1) T. Stams, et al., Protein Science 7, 556 (1998), (2) P.A. Boriack-Sjodin, et al., Protein Science 7, 2483 (1998), (3) C.J. Ingram & R.F. Brubaker, Am. J. Ophthalmol. 128, 292 (1999), (4) G.E. Barnes, et al., Survey of Ophthalmol. 44, S131 (2012), (5) H. Zheng & B. Lou, Acta Crystallogr. E Crystallogr. Commun. 72, 692 (2016), (6) T. Nakano, et al., Adv. Ther. 33, 1452 (2016), (7) Y.R. Dong, et al., Int. J. Ophthalmol. 11, 719 (2018)

      Quantity

      10 mg, 50 mg, Bulk

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