Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White solid
- Identity
- 1H-NMR
Properties
- Solvents
- chloroform
- Melting Point
- 112-114 °C (lit.)
- Optical Activity
- [α]24/D -44°, c = 2 in chloroform
Available from stock
Cholesteryl acetate
- SKU
- C0359
Category: Steroids
- Synonyms
- Cholesterol acetate , 3β-Acetoxy-5-cholestene , 3β-Hydroxy-5-cholestene 3-acetate , 5-Cholesten-3β-ol 3-acetate , NSC 8799
- 604-35-3
- CAS-Number
- C29H48O2
- Molecular Formula
- 428.69
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- RT
- Long Term Storage
- +4°C
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at +4°C.
- Transportation
- Not dangerous goods
- Description
- Cholesteryl acetate is a normal human cholesteryl ester present in diverse fluids and organs. Cholesteryl acetate is also present in foods. Food oxidation affects the quality and safety of the human diet by generating compounds with biological activities that can adversely affect health. In particular the susceptibility of cholesterol to oxidation is well known| certain products of cholesterol oxidation have been reported to produce cytotoxic, angiotoxic and carcinogenic effects. Cholesteryl ester (CE) is the major transport and storage form of cholesterol in lipoprotein particles and most cell types. Molecular composition of CE species is of high interest for arteriosclerosis research, i. e. , as components of lipoprotein subclasses or in studies investigating the mechanisms involved in the generation of lipid laden foam cells. Thus, it has been shown that CE species in circulating plasma are strongly correlated with development of coronary heart disease. Cholesteryl acetate is used in cosmetics or pharmaceuticals.
- Smiles
- C[C@H](CCCC(C)C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](OC(C)=O)CC[C@]4(C)[C@@]3([H])CCC21C
- InChi Key
- XUGISPSHIFXEHZ-JWAONGLTSA-N
- References
- (1) P. Sawzik & B.M. Craven , Acta Cryst. 35, 895 (1979) , (2) E.G. Perkins, et al. , Lipids 16, 609 (1981) , (3) P.J. Dolphin, et al. , Atheroscler. 51, 109 (1984) , (4) B. Sjostrom, et al. , J. Pharm. Sci. 82, 584 (1993) , (5) B. Sjostrom, et al. , Int. J. Pharm. 94, 89 (1993) , (6) B. Sjostrom, et al. , Pharm. Res. 12, 39 (1995) , (7) F.P. Ballistreri, et al. , Steroids 71, 565 (2006) , (8) D.A. Aleksandrov, et al. , FEBS J. 273, 548 (2006) , (9) I. Gvozdovskyy & L. Lisetski , Europ. Phys. J. E 24, 211 (2007)
Cholesteryl acetate is a normal human cholesteryl ester present in diverse fluids and organs. Cholesteryl acetate is also present in foods. Food oxidation affects the quality and safety of the human diet by generating compounds with biological activities that can adversely affect health. In particular the susceptibility of cholesterol to oxidation is well known| certain products of cholesterol oxidation have been reported to produce cytotoxic, angiotoxic and carcinogenic effects. Cholesteryl ester (CE) is the major transport and storage form of cholesterol in lipoprotein particles and most cell types. Molecular composition of CE species is of high interest for arteriosclerosis research, i. e. , as components of lipoprotein subclasses or in studies investigating the mechanisms involved in the generation of lipid laden foam cells. Thus, it has been shown that CE species in circulating plasma are strongly correlated with development of coronary heart disease. Cholesteryl acetate is used in cosmetics or pharmaceuticals.
Additional information
| Synonyms | Cholesterol acetate, 3β-Acetoxy-5-cholestene, 3β-Hydroxy-5-cholestene 3-acetate, 5-Cholesten-3β-ol 3-acetate, NSC 8799 |
|---|---|
| Purity | ≥98% (HPLC) |
| Appearance | White solid |
| CAS-Number | 604-35-3 |
| Molecular Formula | C29H48O2 |
| Molecular Weight | 428.69 |
| Identity | 1H-NMR |
| Solvents | chloroform |
| Melting Point | 112-114 °C (lit.) |
| Optical Activity | [α]24/D -44°, c = 2 in chloroform |
| Smiles | C[C@H](CCCC(C)C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](OC(C)=O)CC[C@]4(C)[C@@]3([H])CCC21C |
| InChi Key | XUGISPSHIFXEHZ-JWAONGLTSA-N |
| Shipping | AMBIENT |
| Short Term Storage | RT |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Transportation | Not dangerous goods |
| References | (1) P. Sawzik & B.M. Craven, Acta Cryst. 35, 895 (1979), (2) E.G. Perkins, et al., Lipids 16, 609 (1981), (3) P.J. Dolphin, et al., Atheroscler. 51, 109 (1984), (4) B. Sjostrom, et al., J. Pharm. Sci. 82, 584 (1993), (5) B. Sjostrom, et al., Int. J. Pharm. 94, 89 (1993), (6) B. Sjostrom, et al., Pharm. Res. 12, 39 (1995), (7) F.P. Ballistreri, et al., Steroids 71, 565 (2006), (8) D.A. Aleksandrov, et al., FEBS J. 273, 548 (2006), (9) I. Gvozdovskyy & L. Lisetski, Europ. Phys. J. E 24, 211 (2007) |
| Quantity | 50 g, 100 g, Bulk |
