• Start
Search

Results for {phrase} ({results_count} of {results_count_total})

Displaying {results_count} results of {results_count_total}

More results...

Generic filters
Filter by Product categories
Bioactive Molecules
Amino Acids, Peptides, Proteins
Carbohydrates
Lipids, Fatty Acids
Metabolites
Phytochemicals
Vitamins
Bioactive Small Molecules
Biopolymers
Detection in Bioanalysis
Fluorescent Detection
Organic Pollutants & Pesticides
Fungicides
Herbicides
Insecticides
Other Pollutants
Pharmaceutically Actives
Antibiotics
API's & Intermediates
Steroids
Reagents and Building Blocks
Reagents for Life Sciences
Buffers
Building Blocks, Intermediates, Reagents
Fluorescent Detection
Linker
Non Fluorescent Detection & Chromogene Detection
Quorum Sensing
Uncategorized
    Industriestrasse 15, CH-9015 St. Gallen, Switzerland, Tel: +41 71 244 48 25
    • 0Einkaufswagen
    Chemodex
    • Start
    • Produkte (engl.)
    • Über Chemodex
    • Kontakt & Distributoren
    • Menü Menü
    Clomiphene citrate

    Available from stock

      Inquiry

      Please fill out the form for your inquiry:



      * required field

      Clomiphene citrate

      SKU
      C0696

      Category: API's & Intermediates

      Synonyms
      Clomifene , Omifin , NSC 35770 , 2-(4-[2-Chloro-1,2-diphenylethenyl]phenoxy)-N,N-diethylethanamine , Clomiphene citrate salt
      50-41-9
      CAS-Number
      C26H28ClNO · C6H8O7
      Molecular Formula
      598.08
      Molecular Weight

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥98% (HPLC)
      Identity
      1H-NMR
      Appearance
      Solid

      Properties

      Solvents
      DMSO, DMF, water (slightly), methanol (slightly), chloroform (slightly)
      Handling Advice
      Protect from light and moisture.
      Use / Stability
      Stable for at least 2 years after receipt when stored at +4°C.
      Long Term Storage
      +4°C
      Short Term Storage
      +4°C
      Shipping
      AMBIENT
      Transportation
      Not dangerous goods
      Signal word
      Warning
      GHS Symbol
      GHS08
      Precautionary statements
      P281
      Hazard statements
      H361
      Description
      Clomiphene is a nonsteroidal triphenylethylene derivative. It acts as a selective estrogen receptor modulator (SERM), that impairs the activation of estrogen receptors (ERs) by 17β-estradiol, similar to tamoxifen and raloxifene. It potently binds both ERα and ERβ (Ki = 0.9 and 1.2nM, respectively). Clomiphene enhances the release of gonadotropin-releasing hormone, stimulating the release of follicle-stimulating hormone and luteinizing hormone, culminating in ovulation. Triphenylethylene antiestrogens may also be used as antileukemic drugs which kill cells by apoptosis mediated by oxidative stress and activation of PKC.
      References
      (1) J.H. Clark & B.M. Markaverich, Pharmacol. Ther. 15, 467 (1981) , (2) E.Y. Adashi, Fertil. Steril. 42, 331 (1984) , (3) E. Kousta, et al., Hum. Reprod. Update 3, 359 (1997) , (4) G.G.J.M. Kuiper, et al., Endocrinology 138, 863 (1997) , (5) T. Hayon, et al., Anticancer Res. 19, 2089 (1999) , (6) S.G. Haskell, South Med. J. 96, 469 (2003) , (7) R. Homburg, Hum. Reprod. 20, 2043 (2005) , (8) M. Amita, et al., Endocrinology 151, 394 (2010)
      InChi Key
      PYTMYKVIJXPNBD-BTKVJIOYSA-N
      Smiles
      Cl/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)C3=CC=C(OCCN(CC)CC)C=C3.OC(CC(O)=O)(C(O)=O)CC(O)=O

      Clomiphene is a nonsteroidal triphenylethylene derivative. It acts as a selective estrogen receptor modulator (SERM), that impairs the activation of estrogen receptors (ERs) by 17β-estradiol, similar to tamoxifen and raloxifene. It potently binds both ERα and ERβ (Ki = 0.9 and 1.2nM, respectively). Clomiphene enhances the release of gonadotropin-releasing hormone, stimulating the release of follicle-stimulating hormone and luteinizing hormone, culminating in ovulation. Triphenylethylene antiestrogens may also be used as antileukemic drugs which kill cells by apoptosis mediated by oxidative stress and activation of PKC.

      Artikelnummer: C0696 Kategorie: API's & Intermediates
      • Zusätzliche Information

      Zusätzliche Information

      Synonyms

      Clomifene, Omifin, NSC 35770, 2-(4-[2-Chloro-1,2-diphenylethenyl]phenoxy)-N,N-diethylethanamine, Clomiphene citrate salt

      Purity

      ≥98% (HPLC)

      Appearance

      Solid

      CAS-Number

      50-41-9

      Molecular Formula

      C26H28ClNO · C6H8O7

      Molecular Weight

      598.08

      Identity

      1H-NMR

      Solvents

      DMSO, DMF, water (slightly), methanol (slightly), chloroform (slightly)

      Smiles

      Cl/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)C3=CC=C(OCCN(CC)CC)C=C3.OC(CC(O)=O)(C(O)=O)CC(O)=O

      InChi Key

      PYTMYKVIJXPNBD-BTKVJIOYSA-N

      Shipping

      AMBIENT

      Short Term Storage

      +4°C

      Long Term Storage

      +4°C

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at +4°C.

      Hazard statements

      H361

      Precautionary statements

      P281

      GHS Symbol

      GHS08

      Signal word

      Warning

      Transportation

      Not dangerous goods

      References

      (1) J.H. Clark & B.M. Markaverich, Pharmacol. Ther. 15, 467 (1981), (2) E.Y. Adashi, Fertil. Steril. 42, 331 (1984), (3) E. Kousta, et al., Hum. Reprod. Update 3, 359 (1997), (4) G.G.J.M. Kuiper, et al., Endocrinology 138, 863 (1997), (5) T. Hayon, et al., Anticancer Res. 19, 2089 (1999), (6) S.G. Haskell, South Med. J. 96, 469 (2003), (7) R. Homburg, Hum. Reprod. 20, 2043 (2005), (8) M. Amita, et al., Endocrinology 151, 394 (2010)

      Quantity

      1 g, 5 g, Bulk

      Ähnliche Produkte

      • Gemcitabine hydrochloride

        Gemcitabine hydrochloride

        Purity: ≥98% (HPLC)CAS-Number: 122111-03-9SKU: G0063

        Weiterlesen Details anzeigen
      • (±)-Lisofylline

        (±)-Lisofylline

        Purity: ≥99% (HPLC)CAS-Number: 6493-06-7SKU: H0117

        Weiterlesen Details anzeigen
      • Diclofenac acid

        Diclofenac acid

        Purity: ≥98% (HPLC)CAS-Number: 15307-86-5SKU: D0147

        Weiterlesen Details anzeigen
      • Aluminon

        Aluminon

        Purity: n.a.CAS-Number: 569-58-4SKU: A0293

        Weiterlesen Details anzeigen
      © Copyright - Chemodex Ltd. - Customized Molecules developed in Switzerland
      • Start
      • Alle Produkte
      • Bestell- und Lieferinformationen
      • Haftungsausschluss
      • Impressum
      • Datenschutzerklärung
      Sulfo-NHS-LC-Biotin Sulfo-NHS-LC-Biotin Ketorolac tris salt Ketorolac tris salt Nach oben scrollen