Clopidogrel bisulfate

SKU: D0505

Category: API's & Intermediates

Synonyms: Clopidogrel bisulfate , Clopidogrel Hemisulfate , SR 25990C , (S)-Methyl (2-chlorophenyl)(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetate hydrogensulfate; 120202-66-6
CAS-Number: C₁₆H₁₆ClNO₂S · H₂SO₄
Molecular Formula: 419.90
Molecular Weight

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Identity: 1H-NMR
Appearance: White to off-white powder

Properties

Solvents: DMSO (>30mg/ml), methanol, water (>30mg/ml)

Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at +4°C.
Long Term Storage: +4°C
Short Term Storage: +4°C
Shipping: AMBIENT

Transportation: Packing Group I
RIDADR: 2928 6.1(8)
Signal word: Danger
GHS Symbol: GHS05+GHS06+GHS09
Precautionary statements: P260-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338
Hazard statements: H300-H314-H411

Description: (S)-(+)-Clopidogrel is a prodrug that is metabolized by cytochrome P450 isoforms to produce an active metabolite, which is a selective, irreversible high-affinity antagonist of the platelet purinergic P2Y12 receptor. Potent antithrombotic antiplatelet agent. By inhibiting the Purinoceptor P2Y12 subtype it consequently inhibits ADP-induced platelet aggregation. (S)-(+)-Clopidogrel hydrogen sulfate is the active isomer. Compound can be used as analytical reference material.
References: (1) D.C.B. Mills, et al., Arterioscler. Thromb. 12, 430 (1992) , (2) G. Feuerstein, et al., Exp. Opin. Invest. Drugs 4, 425 (1995) , (3) P. Savi, et al., BBRC 283, 379 (2001) , (4) P. Savi & J.M. Herbert, Se≥ Thromb. Haemostas. 31, 174 (2005) , (5) I. von Kugelgen, Pharmacol.Ther. 110, 415 (2006) , (6) N. Ferri, et al., Drugs 73, 1681 (2013)
InChi Key: FDEODCTUSIWGLK-UHFFFAOYSA-N
Smiles: ClC1=CC=CC=C1[C@H]([NH+]2CCC(SC=C3)=C3C2)C(OC)=O.[O-]S(=O)(O)=O

(S)-(+)-Clopidogrel is a prodrug that is metabolized by cytochrome P450 isoforms to produce an active metabolite, which is a selective, irreversible high-affinity antagonist of the platelet purinergic P2Y12 receptor. Potent antithrombotic antiplatelet agent. By inhibiting the Purinoceptor P2Y12 subtype it consequently inhibits ADP-induced platelet aggregation. (S)-(+)-Clopidogrel hydrogen sulfate is the active isomer. Compound can be used as analytical reference material.

Artikelnummer: D0505 Kategorie: API's & Intermediates

Zusätzliche Information

Zusätzliche Information

Synonyms	Clopidogrel bisulfate, Clopidogrel Hemisulfate, SR 25990C, (S)-Methyl (2-chlorophenyl)(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetate hydrogensulfate
Purity	≥98% (HPLC)
Appearance	White to off-white powder
CAS-Number	120202-66-6
Molecular Formula	C16H16ClNO2S · H2SO4
Molecular Weight	419.90
Identity	1H-NMR
Solvents	DMSO (>30mg/ml), methanol, water (>30mg/ml)
Smiles	ClC1=CC=CC=C1[C@H]([NH+]2CCC(SC=C3)=C3C2)C(OC)=O.[O-]S(=O)(O)=O
InChi Key	FDEODCTUSIWGLK-UHFFFAOYSA-N
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at +4°C.
Hazard statements	H300-H314-H411
Precautionary statements	P260-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338
GHS Symbol	GHS05+GHS06+GHS09
Signal word	Danger
RIDADR	2928 6.1(8)
Transportation	Packing Group I
References	(1) D.C.B. Mills, et al., Arterioscler. Thromb. 12, 430 (1992), (2) G. Feuerstein, et al., Exp. Opin. Invest. Drugs 4, 425 (1995), (3) P. Savi, et al., BBRC 283, 379 (2001), (4) P. Savi & J.M. Herbert, Se≥ Thromb. Haemostas. 31, 174 (2005), (5) I. von Kugelgen, Pharmacol.Ther. 110, 415 (2006), (6) N. Ferri, et al., Drugs 73, 1681 (2013)
Quantity	250 mg, Bulk