Specifications
- Purity
- ≥98% (HPLC)
- Identity
- 1H-NMR
- Appearance
- White to off-white powder
Properties
- Solvents
- choroform, DMSO, methanol
Category: API's & Intermediates
Crizotinib is an anticancer drug. It is a potent, orally bioavailable, ATP-competitive inhibitor of the receptor tyrosine kinases (RTKs) c-Met (hepatocyte growth factor receptor), anaplastic lymphoma kinase (ALK) and and ROS1 (c-ros oncogene 1). Selective for c-MET and ALK against >120 different kinases. Displays antitumor efficacy in multiple tumor models| inhibits c-MET-dependent proliferation, migration and invasion of human tumor cells in vitro. Orally bioavailable. Crizotinib was approved for treatment of a subtype of nonsmall-cell lung cancer (NSCLC) with ALK fusion mutations.
Synonyms | (R)-3-[1-(2,6-Dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine, PF 2341066, PF-02341066, PF02341066, Xalkori |
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Purity | ≥98% (HPLC) |
Appearance | White to off-white powder |
CAS-Number | 877399-52-5 |
Molecular Formula | C21H22Cl2FN5O |
Molecular Weight | 450.34 |
Identity | 1H-NMR |
Solvents | choroform, DMSO, methanol |
Smiles | NC1=NC=C(C2=CN(C3CCNCC3)N=C2)C=C1O[C@H](C)C4=C(Cl)C(F)=CC=C4Cl |
InChi Key | KTEIFNKAUNYNJU-GFCCVEGCSA-N |
Shipping | AMBIENT |
Short Term Storage | RT |
Long Term Storage | +4°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
Hazard statements | H317-H319-H341-H400 |
Precautionary statements | P273-P280-P305 + P351 + P338 |
GHS Symbol | GHS07+GHS08+GHS09 |
Signal word | Warning |
RIDADR | UN 3077 9 |
Transportation | Packing Group III |
References | (1) H.Y. Zou, et al., Cancer Res. 67, 4408 (2007), (2) J.G. Christensen, et al., Mol. Cancer Ther. 6, 3314 (2007), (3) J.J. Cui, et al., J. Med. Chem. 54, 6342 (2011), (4) J. Tanizaki, et al., J. Thorac. Oncol. 6, 1624 (2011), (5) Y. Yuan, et al., J. Hematol. Oncol. 4, 1 (2011), (6) A.T. Shaw, et al., N. Engl. J. Med. 371, 1963 (2014) |
Quantity | 10 mg, 50 mg, Bulk |