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    Crizotinib

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      Crizotinib

      SKU
      C0699

      Category: API's & Intermediates

      Synonyms
      (R)-3-[1-(2,6-Dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine , PF 2341066 , PF-02341066 , PF02341066 , Xalkori
      877399-52-5
      CAS-Number
      C21H22Cl2FN5O
      Molecular Formula
      450.34
      Molecular Weight

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥98% (HPLC)
      Identity
      1H-NMR
      Appearance
      White to off-white powder

      Properties

      Solvents
      choroform, DMSO, methanol
      Handling Advice
      Protect from light and moisture.
      Use / Stability
      Stable for at least 2 years after receipt when stored at +4°C.
      Long Term Storage
      +4°C
      Short Term Storage
      RT
      Shipping
      AMBIENT
      Transportation
      Packing Group III
      RIDADR
      UN 3077 9
      Signal word
      Warning
      GHS Symbol
      GHS07+GHS08+GHS09
      Precautionary statements
      P273-P280-P305 + P351 + P338
      Hazard statements
      H317-H319-H341-H400
      Description
      Crizotinib is an anticancer drug. It is a potent, orally bioavailable, ATP-competitive inhibitor of the receptor tyrosine kinases (RTKs) c-Met (hepatocyte growth factor receptor), anaplastic lymphoma kinase (ALK) and and ROS1 (c-ros oncogene 1). Selective for c-MET and ALK against >120 different kinases. Displays antitumor efficacy in multiple tumor models| inhibits c-MET-dependent proliferation, migration and invasion of human tumor cells in vitro. Orally bioavailable. Crizotinib was approved for treatment of a subtype of nonsmall-cell lung cancer (NSCLC) with ALK fusion mutations.
      References
      (1) H.Y. Zou, et al., Cancer Res. 67, 4408 (2007) , (2) J.G. Christensen, et al., Mol. Cancer Ther. 6, 3314 (2007) , (3) J.J. Cui, et al., J. Med. Chem. 54, 6342 (2011) , (4) J. Tanizaki, et al., J. Thorac. Oncol. 6, 1624 (2011) , (5) Y. Yuan, et al., J. Hematol. Oncol. 4, 1 (2011) , (6) A.T. Shaw, et al., N. Engl. J. Med. 371, 1963 (2014)
      InChi Key
      KTEIFNKAUNYNJU-GFCCVEGCSA-N
      Smiles
      NC1=NC=C(C2=CN(C3CCNCC3)N=C2)C=C1O[C@H](C)C4=C(Cl)C(F)=CC=C4Cl

      Crizotinib is an anticancer drug. It is a potent, orally bioavailable, ATP-competitive inhibitor of the receptor tyrosine kinases (RTKs) c-Met (hepatocyte growth factor receptor), anaplastic lymphoma kinase (ALK) and and ROS1 (c-ros oncogene 1). Selective for c-MET and ALK against >120 different kinases. Displays antitumor efficacy in multiple tumor models| inhibits c-MET-dependent proliferation, migration and invasion of human tumor cells in vitro. Orally bioavailable. Crizotinib was approved for treatment of a subtype of nonsmall-cell lung cancer (NSCLC) with ALK fusion mutations.

      Artikelnummer: C0699 Kategorie: API's & Intermediates
      • Zusätzliche Information

      Zusätzliche Information

      Synonyms

      (R)-3-[1-(2,6-Dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine, PF 2341066, PF-02341066, PF02341066, Xalkori

      Purity

      ≥98% (HPLC)

      Appearance

      White to off-white powder

      CAS-Number

      877399-52-5

      Molecular Formula

      C21H22Cl2FN5O

      Molecular Weight

      450.34

      Identity

      1H-NMR

      Solvents

      choroform, DMSO, methanol

      Smiles

      NC1=NC=C(C2=CN(C3CCNCC3)N=C2)C=C1O[C@H](C)C4=C(Cl)C(F)=CC=C4Cl

      InChi Key

      KTEIFNKAUNYNJU-GFCCVEGCSA-N

      Shipping

      AMBIENT

      Short Term Storage

      RT

      Long Term Storage

      +4°C

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at +4°C.

      Hazard statements

      H317-H319-H341-H400

      Precautionary statements

      P273-P280-P305 + P351 + P338

      GHS Symbol

      GHS07+GHS08+GHS09

      Signal word

      Warning

      RIDADR

      UN 3077 9

      Transportation

      Packing Group III

      References

      (1) H.Y. Zou, et al., Cancer Res. 67, 4408 (2007), (2) J.G. Christensen, et al., Mol. Cancer Ther. 6, 3314 (2007), (3) J.J. Cui, et al., J. Med. Chem. 54, 6342 (2011), (4) J. Tanizaki, et al., J. Thorac. Oncol. 6, 1624 (2011), (5) Y. Yuan, et al., J. Hematol. Oncol. 4, 1 (2011), (6) A.T. Shaw, et al., N. Engl. J. Med. 371, 1963 (2014)

      Quantity

      10 mg, 50 mg, Bulk

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