Specifications
- Purity
- ≥99% (HPLC)
- Identity
- 1H-NMR
- Appearance
- White to off-white powder
Properties
- Solvents
- water (10 mg/ml), DMSO (20 mg/ml), DMF (30 mg/ml)
Available from stock
D-(-)-Salicin
- SKU
- S0001
Category: Carbohydrates
- Synonyms
- D-(-)-Salicin , 2-(Hydroxymethyl)phenyl-&beta-D-glucopyranoside , Salicoside , Salicyl alcohol glucoside , Saligenin β-D-glucoside , NSC 5751
- 138-52-3
- CAS-Number
- C13H18O7
- Molecular Formula
- 286.28
- Molecular Weight
- Short Term Storage
- RT
- Use / Stability
- Stable for at least 2 years after receipt when stored at RT.
- Handling Advice
- Protect from light and moisture.
- Long Term Storage
- RT
- Shipping
- AMBIENT
- Transportation
- Not dangerous goods
- Description
- Salicin is an alcoholic β,-glucoside derived from willow bark that produces antioxidant and anti-inflammatory (including analgesic and antipyretic) effects very similar to that of aspirin. It acts as a non-selective COX inhibitor for COX-1 and COX-2. It has been used in the treatment of rheumatism. Shown to inhibit angiogenesis by blocking the ROS-ERK pathways and to have in vivo anticancer activity.
- References
- (1) T. Maclagan, Br. Med. J. 1, 627 (1876) , (2) T.D. Warner, et al., PNAS 96, 7563 (1999) , (3) I. Wagner & L. Heide, J. Rheumatol. 30, 1125 (2003) , (4) A.L. Blobaum & L.J. Marnett, J. Med. Chem. 50, 1425 (2007) , (5) N. Verma, et al., Inflamm. Res. 63, 161 (2014) , (6) C.S. Kong, et al., Phytother. Res. 28, 1246 (2014) , (7) Y. Li, et al., Int. Immunopharmacol. 26, 286 (2015) , (8) M. Sabaa, et al., Naunyn Schmiedebergs Arch. Pharmacol. 390, 1061 (2017)
- InChi Key
- NGFMICBWJRZIBI-UJPOAAIJSA-N
- Smiles
- C1=CC=C(C(=C1)CO)OC2C(C(C(C(O2)CO)O)O)O
Salicin is an alcoholic β,-glucoside derived from willow bark that produces antioxidant and anti-inflammatory (including analgesic and antipyretic) effects very similar to that of aspirin. It acts as a non-selective COX inhibitor for COX-1 and COX-2. It has been used in the treatment of rheumatism. Shown to inhibit angiogenesis by blocking the ROS-ERK pathways and to have in vivo anticancer activity.
Zusätzliche Information
| Synonyms | D-(-)-Salicin, 2-(Hydroxymethyl)phenyl-&beta-D-glucopyranoside, Salicoside, Salicyl alcohol glucoside, Saligenin β-D-glucoside, NSC 5751 |
|---|---|
| Purity | ≥99% (HPLC) |
| Appearance | White to off-white powder |
| CAS-Number | 138-52-3 |
| Molecular Formula | C13H18O7 |
| Molecular Weight | 286.28 |
| Identity | 1H-NMR |
| Solvents | water (10 mg/ml), DMSO (20 mg/ml), DMF (30 mg/ml) |
| Smiles | C1=CC=C(C(=C1)CO)OC2C(C(C(C(O2)CO)O)O)O |
| InChi Key | NGFMICBWJRZIBI-UJPOAAIJSA-N |
| Shipping | AMBIENT |
| Short Term Storage | RT |
| Long Term Storage | RT |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at RT. |
| Transportation | Not dangerous goods |
| References | (1) T. Maclagan, Br. Med. J. 1, 627 (1876), (2) T.D. Warner, et al., PNAS 96, 7563 (1999), (3) I. Wagner & L. Heide, J. Rheumatol. 30, 1125 (2003), (4) A.L. Blobaum & L.J. Marnett, J. Med. Chem. 50, 1425 (2007), (5) N. Verma, et al., Inflamm. Res. 63, 161 (2014), (6) C.S. Kong, et al., Phytother. Res. 28, 1246 (2014), (7) Y. Li, et al., Int. Immunopharmacol. 26, 286 (2015), (8) M. Sabaa, et al., Naunyn Schmiedebergs Arch. Pharmacol. 390, 1061 (2017) |
| Quantity | 25 g, 100 g, Bulk |
