Specifications
- Purity
- ≥99% (HPLC)
- Identity
- 1H-NMR
- Appearance
- White to off-white powder
Properties
- Melting Point
- 99-101 °C (lit.)
- Solvents
- water (50mg/ml), DMSO (50mg/ml), ethanol (50mg/ml)
Available from stock
Dibucaine hydrochloride
- SKU
- C0693
Category: API's & Intermediates
- Synonyms
- Cinchocaine hydrochloride , 2-Butoxy-N-(2-diethylaminoethyl)-4-quinolinecarboxamide hydrochloride
- 61-12-1
- CAS-Number
- C20H29N3O2 · HCl
- Molecular Formula
- 379.92
- Molecular Weight
- Long Term Storage
- -20°C
- Use / Stability
- Stable for at least 2 years after receipt when stored at -20°C.
- Handling Advice
- Protect from light and moisture.
- Short Term Storage
- +4°C
- Shipping
- AMBIENT
- Transportation
- Not dangerous goods
- Signal word
- Danger
- GHS Symbol
- GHS05+GHS07
- Precautionary statements
- P280-P305 + P351 + P338
- Hazard statements
- H302-H318
- Description
- Dibucaine is a long-acting local anesthetic. Potent Na+ channel blocker. It blocks both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade. Induces apoptosis through calpain, cytochrome oxidase etc, and shows antiviral and antiparasitic activity.
- References
- (1) G.R. Padmanabhan, et al., Anal. Profiles Drug Subs. 12, 105 (1983) , (2) A Seelig, Biochim. Biophys. Acta 899, 196 (1987) , (3) E. Garcia-Martin & C. Gutierrez-Merino, J. Neurochem. 54, 1238 (1990) , (4) B.K. Stringer & H.J. Harmon, Biochem. Pharmacol. 40, 1077 (1990) , (5) A. Oda, et al., Am. J. Physiol. 269, C118 (1995) , (6) Y. Kuroda, et al., Biophys. J. 71, 1191 (1996) , (7) M. Kim, et al., Exp. Cell Res. 231, 235 (1997) , (8) M. Kansha, et al., Anesthesiology 91, 1798 (1999) , (9) K. Arita, et al., Biochem. Pharmacol. 60, 905 (2000) , (10) T. Souto-Padron, et al., Parasitol. Res. 99, 317 (2006) , (11) W. Zhang, et al., Int. J. Mol. Sci. 12, 2125 (2011) , (12) H.A. Douglas, et al., J. Neurophysiol. 105, 1482 (2011) , (13) R. Ulferts, et al., Antimicrob. Agents Chemother. 60, 2627 (2016)
- InChi Key
- IVHBBMHQKZBJEU-UHFFFAOYSA-N
- Smiles
- O=C(NCCN(CC)CC)C1=CC(OCCCC)=NC2=CC=CC=C21.Cl
Dibucaine is a long-acting local anesthetic. Potent Na+ channel blocker. It blocks both the initiation and conduction of nerve impulses by decreasing the neuronal membrane’s permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade. Induces apoptosis through calpain, cytochrome oxidase etc, and shows antiviral and antiparasitic activity.
Zusätzliche Information
| Synonyms | Cinchocaine hydrochloride, 2-Butoxy-N-(2-diethylaminoethyl)-4-quinolinecarboxamide hydrochloride |
|---|---|
| Purity | ≥99% (HPLC) |
| Appearance | White to off-white powder |
| CAS-Number | 61-12-1 |
| Molecular Formula | C20H29N3O2 · HCl |
| Molecular Weight | 379.92 |
| Identity | 1H-NMR |
| Solvents | water (50mg/ml), DMSO (50mg/ml), ethanol (50mg/ml) |
| Melting Point | 99-101 °C (lit.) |
| Smiles | O=C(NCCN(CC)CC)C1=CC(OCCCC)=NC2=CC=CC=C21.Cl |
| InChi Key | IVHBBMHQKZBJEU-UHFFFAOYSA-N |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Hazard statements | H302-H318 |
| Precautionary statements | P280-P305 + P351 + P338 |
| GHS Symbol | GHS05+GHS07 |
| Signal word | Danger |
| Transportation | Not dangerous goods |
| References | (1) G.R. Padmanabhan, et al., Anal. Profiles Drug Subs. 12, 105 (1983), (2) A Seelig, Biochim. Biophys. Acta 899, 196 (1987), (3) E. Garcia-Martin & C. Gutierrez-Merino, J. Neurochem. 54, 1238 (1990), (4) B.K. Stringer & H.J. Harmon, Biochem. Pharmacol. 40, 1077 (1990), (5) A. Oda, et al., Am. J. Physiol. 269, C118 (1995), (6) Y. Kuroda, et al., Biophys. J. 71, 1191 (1996), (7) M. Kim, et al., Exp. Cell Res. 231, 235 (1997), (8) M. Kansha, et al., Anesthesiology 91, 1798 (1999), (9) K. Arita, et al., Biochem. Pharmacol. 60, 905 (2000), (10) T. Souto-Padron, et al., Parasitol. Res. 99, 317 (2006), (11) W. Zhang, et al., Int. J. Mol. Sci. 12, 2125 (2011), (12) H.A. Douglas, et al., J. Neurophysiol. 105, 1482 (2011), (13) R. Ulferts, et al., Antimicrob. Agents Chemother. 60, 2627 (2016) |
| Quantity | 1 g, 5 g, 25 g, Bulk |
