Available from stock

Digoxin

SKU: D0175

Category: Phytochemicals

Synonyms: 12β-Hydroxydigitoxin , NSC 95100; 20830-75-5
CAS-Number: C₄₁H₆₄O₁₄
Molecular Formula: 780.94
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥95% (HPLC)
Appearance: White powder
Identity: 1H-NMR

Properties

Solvents: DMSO, methanol, dilute alcohol, a mixture of chloroform and alcohol, and water (0.06 mg/ml at 25 °C)
Melting Point: 248-250°C
Density: ~1.4 g/cm3

Documentation

Safety Data Sheet (SDS): CDX D0175 MSDS_V1.2.pdf
Safety Data Sheet (SDS): CDX D0175 MSDS.pdf

Shipping: AMBIENT
Short Term Storage: RT
Long Term Storage: RT
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at RT.

Hazard statements: H300 + H330
Precautionary statements: P260-P264-P284-P301 + P310-P310
GHS Symbol: GHS06
Signal word: Danger
RIDADR: UN3462 6.1
Transportation: Packing Group II

Description: Cardiac glycoside from the leaves of Digitalis lanata. It is used to treat cardiac arrhythmias. It is often used as a model substrate of P-glycoprotein (Pgp) (0.01-10 µM) and an inhibitor of Na+/K+-ATPase. Inhibits membrane-bound ?-subunits of the Na+/K+ ATPase pump in myocytes. The primary mechanism of action involves inhibition of the Na+/K+ ATPase, mainly in the myocardium. This inhibition causes an increase in intracellular sodium levels, resulting in a reversal of the action of the sodium-calcium exchanger, which causes an increase in the intracellular calcium concentration. This leads to a decrease in heart rate and increased storage of calcium in the sarcoplasmic reticulum, causing a corresponding increase in the release of calcium during each action potential.
Smiles: O=C1OC/C(=C/1)[C@H]2CC[C@@]8(O)[C@]2(C)[C@H](O)C[C@H]7[C@H]8CC[C@H]6[C@]7(C)CC[C@H](O[C@@H]5O[C@H](C)[C@@H](O[C@@H]4O[C@@H]([C@@H](O[C@@H]3O[C@@H]([C@@H](O)[C@@H](O)C3)C)[C@@H](O)C4)C)[C@@H](O)C5)C6
InChi Key: LTMHDMANZUZIPE-PUGKRICDSA-N
References: (1) R.G. Woolfson, et al., Kidney Int. 46, 297 (1994) , (2) S. Reddy, et al., Curr. Opin. Cardiol. 12, 233 (1997) , (3) K. Kjeldsen & H. Bundgaard, Ann. N Y Acad. Sci. 986, 702 (2003) , (4) M. Gheorghiade, et al., Circulation 109, 2959 (2004) , (5) M. Ehle, et al., Crit. Pathw. Cardiol. 10, 93 (2011) , (6) R.J. Biggar, Clin. Cancer Res. 18, 2133 (2012) , (7) A.M. Nader & D.R. Foster, J. Clin. Pharmacol. 54, 3 (2014) , (8) G.A. Ewy, Am. J. Med. 128, 1272 (2015)

Cardiac glycoside from the leaves of Digitalis lanata. It is used to treat cardiac arrhythmias. It is often used as a model substrate of P-glycoprotein (Pgp) (0.01-10 µM) and an inhibitor of Na+/K+-ATPase. Inhibits membrane-bound ?-subunits of the Na+/K+ ATPase pump in myocytes. The primary mechanism of action involves inhibition of the Na+/K+ ATPase, mainly in the myocardium. This inhibition causes an increase in intracellular sodium levels, resulting in a reversal of the action of the sodium-calcium exchanger, which causes an increase in the intracellular calcium concentration. This leads to a decrease in heart rate and increased storage of calcium in the sarcoplasmic reticulum, causing a corresponding increase in the release of calcium during each action potential.

Artikelnummer: D0175 Kategorie: Phytochemicals

Zusätzliche Informationen

Zusätzliche Informationen

Synonyms	12β-Hydroxydigitoxin, NSC 95100
Purity	≥95% (HPLC)
Appearance	White powder
CAS-Number	20830-75-5
Molecular Formula	C41H64O14
Molecular Weight	780.94
Identity	1H-NMR
Solvents	DMSO, methanol, dilute alcohol, a mixture of chloroform and alcohol, and water (0.06 mg/ml at 25 °C)
Melting Point	248-250°C
Density	~1.4 g/cm3
Smiles	O=C1OC/C(=C/1)[C@H]2CC[C@@]8(O)[C@]2(C)[C@H](O)C[C@H]7[C@H]8CC[C@H]6[C@]7(C)CC[C@H](O[C@@H]5O[C@H](C)[C@@H](O[C@@H]4O[C@@H]([C@@H](O[C@@H]3O[C@@H]([C@@H](O)[C@@H](O)C3)C)[C@@H](O)C4)C)[C@@H](O)C5)C6
InChi Key	LTMHDMANZUZIPE-PUGKRICDSA-N
Shipping	AMBIENT
Short Term Storage	RT
Long Term Storage	RT
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at RT.
Hazard statements	H300 + H330
Precautionary statements	P260-P264-P284-P301 + P310-P310
GHS Symbol	GHS06
Signal word	Danger
RIDADR	UN3462 6.1
Transportation	Packing Group II
References	(1) R.G. Woolfson, et al., Kidney Int. 46, 297 (1994), (2) S. Reddy, et al., Curr. Opin. Cardiol. 12, 233 (1997), (3) K. Kjeldsen & H. Bundgaard, Ann. N Y Acad. Sci. 986, 702 (2003), (4) M. Gheorghiade, et al., Circulation 109, 2959 (2004), (5) M. Ehle, et al., Crit. Pathw. Cardiol. 10, 93 (2011), (6) R.J. Biggar, Clin. Cancer Res. 18, 2133 (2012), (7) A.M. Nader & D.R. Foster, J. Clin. Pharmacol. 54, 3 (2014), (8) G.A. Ewy, Am. J. Med. 128, 1272 (2015)
Quantity	1 g, 5 g, Bulk