Specifications
- Purity
- ≥98% (HPLC)
- Identity
- 1H-NMR
- Appearance
- White to off-white powder
Properties
- Solvents
- DMSO (10 mg/ml), DMF (10 mg/ml), methanol, water (slightly)
Available from stock
Entecavir monohydrate
- SKU
- E0229
Category: API's & Intermediates
- Synonyms
- Baraclude , BMS 200475 , SQ 34,676 , 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one monohydrate
- 209216-23-9
- CAS-Number
- C12H15N5O3 · H2O
- Molecular Formula
- 295.29
- Molecular Weight
- Short Term Storage
- RT
- Use / Stability
- Stable for at least 2 years after receipt when stored at RT.
- Handling Advice
- Protect from light and moisture.
- Long Term Storage
- RT
- Shipping
- AMBIENT
- Transportation
- Not dangerous goods
- Description
- Entecavir is an oral antiviral drug used in the treatment of hepatitis B (HBV) infection. It is marketed under the trade name Baraclude (BMS). Entecavir is a potent deoxyguanosine nucleoside analog with antiviral activity selective for hepadnaviruses. In vitro, the active intracellular form of entecavir, entecavir triphosphate, demonstrates a higher binding affinity for HBV DNA polymerase than the natural guanosine triphosphate substrate and effectively inhibits HBV DNA replication at 3 stages in the replication pathway: priming, reverse transcription and DNA-dependent DNA synthesis. Can be also used as a reference compound.
- References
- (1) S.F. Innaimo, et al., Antimicrob. Agents Chemother. 41, 1444 (1997) , (2) M. Seifer, et al., Antimicrob. Agents Chemother. 42, 3200 (1998) , (3) P. Honkoop & R.A. De Man, Expert. Opin. Investig. Drugs 12, 683 (2003) (Review) , (4) S.J. Matthews, Clin. Ther. 28, 184 (2006) (Review) , (5) K.A. Sims & A.M. Woodland, Pharmacotherapy 26, 1745 (2006) (Review) , (6) P.N. Cheng & T.T. Chang, Expert Rev. Anti. Infect. Ther. 6, 569 (2008) (Review)
- InChi Key
- YXPVEXCTPGULBZ-WQYNNSOESA-N
- Smiles
- O=C1C2=C(N([C@H]3C[C@H](O)[C@@H](CO)C3=C)C=N2)NC(N)=N1.O
Entecavir is an oral antiviral drug used in the treatment of hepatitis B (HBV) infection. It is marketed under the trade name Baraclude (BMS). Entecavir is a potent deoxyguanosine nucleoside analog with antiviral activity selective for hepadnaviruses. In vitro, the active intracellular form of entecavir, entecavir triphosphate, demonstrates a higher binding affinity for HBV DNA polymerase than the natural guanosine triphosphate substrate and effectively inhibits HBV DNA replication at 3 stages in the replication pathway: priming, reverse transcription and DNA-dependent DNA synthesis. Can be also used as a reference compound.
Zusätzliche Information
| Synonyms | Baraclude, BMS 200475, SQ 34,676, 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one monohydrate |
|---|---|
| Purity | ≥98% (HPLC) |
| Appearance | White to off-white powder |
| CAS-Number | 209216-23-9 |
| Molecular Formula | C12H15N5O3 · H2O |
| Molecular Weight | 295.29 |
| Identity | 1H-NMR |
| Solvents | DMSO (10 mg/ml), DMF (10 mg/ml), methanol, water (slightly) |
| Smiles | O=C1C2=C(N([C@H]3C[C@H](O)[C@@H](CO)C3=C)C=N2)NC(N)=N1.O |
| InChi Key | YXPVEXCTPGULBZ-WQYNNSOESA-N |
| Shipping | AMBIENT |
| Short Term Storage | RT |
| Long Term Storage | RT |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at RT. |
| Transportation | Not dangerous goods |
| References | (1) S.F. Innaimo, et al., Antimicrob. Agents Chemother. 41, 1444 (1997), (2) M. Seifer, et al., Antimicrob. Agents Chemother. 42, 3200 (1998), (3) P. Honkoop & R.A. De Man, Expert. Opin. Investig. Drugs 12, 683 (2003) (Review), (4) S.J. Matthews, Clin. Ther. 28, 184 (2006) (Review), (5) K.A. Sims & A.M. Woodland, Pharmacotherapy 26, 1745 (2006) (Review), (6) P.N. Cheng & T.T. Chang, Expert Rev. Anti. Infect. Ther. 6, 569 (2008) (Review) |
| Quantity | 50 mg, 200 mg, Bulk |
