- ≥98% (HPLC)
- White to off-white powder
- DMSO (10 mg/ml), DMF (10 mg/ml), methanol, water (slightly)
Category: API's & Intermediates
Entecavir is an oral antiviral drug used in the treatment of hepatitis B (HBV) infection. It is marketed under the trade name Baraclude (BMS). Entecavir is a potent deoxyguanosine nucleoside analog with antiviral activity selective for hepadnaviruses. In vitro, the active intracellular form of entecavir, entecavir triphosphate, demonstrates a higher binding affinity for HBV DNA polymerase than the natural guanosine triphosphate substrate and effectively inhibits HBV DNA replication at 3 stages in the replication pathway: priming, reverse transcription and DNA-dependent DNA synthesis. Can be also used as a reference compound.
Baraclude, BMS 200475, SQ 34,676, 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one monohydrate
White to off-white powder
C12H15N5O3 · H2O
DMSO (10 mg/ml), DMF (10 mg/ml), methanol, water (slightly)
|Short Term Storage||
|Long Term Storage||
Protect from light and moisture.
|Use / Stability||
Stable for at least 2 years after receipt when stored at RT.
Not dangerous goods
(1) S.F. Innaimo, et al., Antimicrob. Agents Chemother. 41, 1444 (1997), (2) M. Seifer, et al., Antimicrob. Agents Chemother. 42, 3200 (1998), (3) P. Honkoop & R.A. De Man, Expert. Opin. Investig. Drugs 12, 683 (2003) (Review), (4) S.J. Matthews, Clin. Ther. 28, 184 (2006) (Review), (5) K.A. Sims & A.M. Woodland, Pharmacotherapy 26, 1745 (2006) (Review), (6) P.N. Cheng & T.T. Chang, Expert Rev. Anti. Infect. Ther. 6, 569 (2008) (Review)
50 mg, 200 mg, Bulk