Available from stock

Genistin

SKU: G0191

Category: Phytochemicals

Synonyms: Genistein glycoside , NSC 5112 , 4',5,7-Trihydroxyisoflavone 7-glucoside; 529-59-9
CAS-Number: C₂₁H₂₀O₁₀
Molecular Formula: 432.38
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥97% (HPLC)
Appearance: Light-Yellow Powder
Identity: 1H-NMR

Properties

Solvents: DMSO (10 mg/ml), DMF (10 mg/ml)
Melting Point: 258-259° C

Shipping: AMBIENT
Short Term Storage: +4°C
Long Term Storage: -20°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at -20°C.

Transportation: Not dangerous goods

Description: Genistin is a natural isoflavone glycoside isolated from legumes (e.g. soy). It is a selective inhibitor of mammalian terminal deoxyribonucleotidyl-transferase (TdT), with no measurable effect on mammalian or microbial DNA polymerases. Disrupts cell cycle and induces apoptosis in human ovarian cancer SK-OV-3 cells. Inhibits UV light-induced plasmid DNA damage and cell growth in human melanoma cells. It is a phytoestrogen, as it stimulates the growth of estrogen-dependent human breast cancer cells in vivo. Like other isoflavones, genistin promotes the proliferation of bone marrow stromal cells and osteoblasts and suppresses bone turnover. It also increases bone formation in collagen matrix in vivo. Could also be used as a negative control for the PTK inhibitor Genistein.
Smiles: OC[C@H]1O[C@@H](OC2=CC(OC=C(C3=CC=C(O)C=C3)C4=O)=C4C(O)=C2)[C@H](O)[C@@H](O)[C@@H]1O
InChi Key: ZCOLJUOHXJRHDI-CMWLGVBASA-N
References: (1) C.D. Allred, et al., Carcinogenesis 22, 1667 (2001) , (2) T. Uesugi, et al., Biol. Pharm. Bull. 24, 368 (2001) , (3) Y. Uchiyama, et al., Biochim. Biophys. Acta, 1725, 298 (2005) , (4) A. Russo, et al., J. Nutr. Biochem. 17, 103 (2006) , (5) E.J. Choi, et al., Life Sci. 80, 1403 (2007) , (6) R.W. Wong & A.B. Rabie, Front. Biosci. 2, 764 (2010)

Genistin is a natural isoflavone glycoside isolated from legumes (e.g. soy). It is a selective inhibitor of mammalian terminal deoxyribonucleotidyl-transferase (TdT), with no measurable effect on mammalian or microbial DNA polymerases. Disrupts cell cycle and induces apoptosis in human ovarian cancer SK-OV-3 cells. Inhibits UV light-induced plasmid DNA damage and cell growth in human melanoma cells. It is a phytoestrogen, as it stimulates the growth of estrogen-dependent human breast cancer cells in vivo. Like other isoflavones, genistin promotes the proliferation of bone marrow stromal cells and osteoblasts and suppresses bone turnover. It also increases bone formation in collagen matrix in vivo. Could also be used as a negative control for the PTK inhibitor Genistein.

SKU: G0191 Category: Phytochemicals

Additional information

Additional information

Synonyms	Genistein glycoside, NSC 5112, 4',5,7-Trihydroxyisoflavone 7-glucoside
Purity	≥97% (HPLC)
Appearance	Light-Yellow Powder
CAS-Number	529-59-9
Molecular Formula	C21H20O10
Molecular Weight	432.38
Identity	1H-NMR
Solvents	DMSO (10 mg/ml), DMF (10 mg/ml)
Melting Point	258-259° C
Smiles	OC[C@H]1O[C@@H](OC2=CC(OC=C(C3=CC=C(O)C=C3)C4=O)=C4C(O)=C2)[C@H](O)[C@@H](O)[C@@H]1O
InChi Key	ZCOLJUOHXJRHDI-CMWLGVBASA-N
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at -20°C.
Transportation	Not dangerous goods
References	(1) C.D. Allred, et al., Carcinogenesis 22, 1667 (2001), (2) T. Uesugi, et al., Biol. Pharm. Bull. 24, 368 (2001), (3) Y. Uchiyama, et al., Biochim. Biophys. Acta, 1725, 298 (2005), (4) A. Russo, et al., J. Nutr. Biochem. 17, 103 (2006), (5) E.J. Choi, et al., Life Sci. 80, 1403 (2007), (6) R.W. Wong & A.B. Rabie, Front. Biosci. 2, 764 (2010)
Quantity	5 mg, 25 mg, Bulk