Available from stock

Hydrocortisone

SKU: H0269

Category: Steroids

Synonyms: 11&beta,17&alpha, 21-Trihydroxypregn-4-ene-3,20-dione, Cortisol, Dihydrocostisone, NSC 10483, Kendall’s compound F, Reichstein’s substance M; 50-23-7
CAS-Number: C₂₁H₃₀O₅
Molecular Formula: 362.46
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Appearance: White to off-white powder
Identity: 1H-NMR

Properties

Solvents: Soluble in DMSO (20mg/ml).
Melting Point: 211-214 °C (lit.)

Shipping: AMBIENT
Short Term Storage: RT
Long Term Storage: RT
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at RT.

Hazard statements: H360Df - H373
Precautionary statements: P202 - P260 - P280 - P308 + P313 - P405 - P501
GHS Symbol: GHS08
Signal word: Danger
Transportation: Not dangerous goods

Description: Hydrocortisone is a glucocorticoid produced by the adrenal cortex in response to adrenocorticotropic hormone (ACTH). Hydrocortisone has three times the anti-inflammatory potency of corticosterone but much lower Na+ retention potency. It is an agonist at the mineralocorticoid receptor (MR) and the glucocorticoid receptor. Hydrocortisone plays a role in the regulation of metabolism, electrolyte balance, water balance, and the body′s stress response. Hydrocortisone production is increased during periods of stress, and it is a major effector molecule in the hypothalamic-pituitary-adrenal axis (HPA) stress response. Cortisol levels increase with age and are often elevated in major depressive disorder, certain forms of hypertension, and Parkinson’s disease. It has been utilized in research to investigate the impact of inflammation and stress on cellular processes.
Smiles: O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])CC[C@]4(O)C(CO)=O)=C1
InChi Key: JYGXADMDTFJGBT-VWUMJDOOSA-N
References: (1) D.T. Matulich, et al.; J. Clin. Endocrinol. Metab. 43, 1170 (1976) , (2) P.E. Stokes; Eur. Neuropsychopharmacol. 5, 77 (1995) , (3) F.P. Varghese & E.S. Brown; Prim. Care Companion. J. Clin. Psychiatry 3, 151 (2001) , (4) M. Quinkler & P.M. Stewart; J. Clin. Endocrinol. Metab. 88, 2384 (2003) , (5) J. Nijm & L. Jonasson; Ann. Med. 41, 224 (2009) , (6) S. Paredes & L. Ribeiro; Rev. Assoc. Med. Bras. 60, 84 (2014) , (7) D.J. van Wamelen, et al.; Int. Rev. Neurobiol. 152, 131 (2020)
InChi: InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

Hydrocortisone is a glucocorticoid produced by the adrenal cortex in response to adrenocorticotropic hormone (ACTH). Hydrocortisone has three times the anti-inflammatory potency of corticosterone but much lower Na+ retention potency. It is an agonist at the mineralocorticoid receptor (MR) and the glucocorticoid receptor. Hydrocortisone plays a role in the regulation of metabolism, electrolyte balance, water balance, and the body′s stress response. Hydrocortisone production is increased during periods of stress, and it is a major effector molecule in the hypothalamic-pituitary-adrenal axis (HPA) stress response. Cortisol levels increase with age and are often elevated in major depressive disorder, certain forms of hypertension, and Parkinson’s disease. It has been utilized in research to investigate the impact of inflammation and stress on cellular processes.

SKU: H0269 Category: Steroids

Additional information

Additional information

Synonyms	11&beta,17&alpha, 21-Trihydroxypregn-4-ene-3,20-dione, Cortisol, Dihydrocostisone, NSC 10483, Kendall’s compound F, Reichstein’s substance M
Purity	≥98% (HPLC)
Appearance	White to off-white powder
CAS-Number	50-23-7
Molecular Formula	C21H30O5
Molecular Weight	362.46
Identity	1H-NMR
Solvents	Soluble in DMSO (20mg/ml).
Melting Point	211-214 °C (lit.)
Smiles	O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])CC[C@]4(O)C(CO)=O)=C1
InChi Key	JYGXADMDTFJGBT-VWUMJDOOSA-N
Shipping	AMBIENT
Short Term Storage	RT
Long Term Storage	RT
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at RT.
Hazard statements	H360Df – H373
Precautionary statements	P202 – P260 – P280 – P308 + P313 – P405 – P501
GHS Symbol	GHS08
Signal word	Danger
Transportation	Not dangerous goods
References	(1) D.T. Matulich, et al.; J. Clin. Endocrinol. Metab. 43, 1170 (1976), (2) P.E. Stokes; Eur. Neuropsychopharmacol. 5, 77 (1995), (3) F.P. Varghese & E.S. Brown; Prim. Care Companion. J. Clin. Psychiatry 3, 151 (2001), (4) M. Quinkler & P.M. Stewart; J. Clin. Endocrinol. Metab. 88, 2384 (2003), (5) J. Nijm & L. Jonasson; Ann. Med. 41, 224 (2009), (6) S. Paredes & L. Ribeiro; Rev. Assoc. Med. Bras. 60, 84 (2014), (7) D.J. van Wamelen, et al.; Int. Rev. Neurobiol. 152, 131 (2020)
InChi	InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
Quantity	1 g, 5 g, 25 g, Bulk