Available from stock

Hyodeoxycholic acid

SKU: H0198

Category: Lipids, Fatty Acids

Synonyms: HDCA , 3α,6α-Dihydroxy-5β-cholan-24-oic acid , NSC 60672 , BRN 3218394 , Iodeoxycholic acid; 83-49-8
CAS-Number: C₂₄H₄₀O₄
Molecular Formula: 392.57
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Appearance: White powder
Identity: 1H-NMR

Properties

Solvents: DMSO (20 mg/ml), DMF (30 mg/ml), ethanol (20 mg/ml)

Shipping: AMBIENT
Short Term Storage: +4°C
Long Term Storage: -20°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at -20°C.

Transportation: Not dangerous goods

Description: Hyodeoxycholic acid is a secondary bile acid. It is produced from lithocholic acid by bacterial action in the colon. Dietary supplementation with HDCA results in decreased plasma VLDL and LDL cholesterol and reduced atherosclerosis in mice. Serum levels of HDCA are increased significantly in Crohn’s disease and ulcerative colitis. Hyodeoxycholic acid can be used as a building block/ precursor for steroid synthesis.
Smiles: O[C@@H]1CC[C@@]2(C)[C@@]([C@@H](O)C[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@@H](CCC(O)=O)C)([H])C1
InChi Key: DGABKXLVXPYZII-SIBKNCMHSA-N
References: (1) W.Z. Chow & D.C. Huang, Sci. Sin. 14, 1083 (1965) , (2) K. Einarsson, J. Biol. Chem. 241, 534 (1966) , (3) K. Ochi, et al., Steroids 30, 795 (1977) , (4) K.R. Bharucha, Steroids 32, 589 (1978) , (5) C.K. McSherry, et al., Am. J. Surg. 149, 126 (1985) , (6) E. Sehayek, et al., J. Lipid Res. 42, 1250 (2001) , (7) C. Gnewuch, et al., World J. Gastroenterol. 15, 3134 (2009) , (8) D.M. Shih, et al., FASEB J. 27, 3805 (2013) , (9) S. Watanabe & K. Fujita, Lipids 49, 963 (2014)
InChi: InChI=1S/C24H40O4/c1-14(4-7-22(27)28)17-5-6-18-16-13-21(26)20-12-15(25)8-10-24(20,3)19(16)9-11-23(17,18)2/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16+,17-,18+,19+,20+,21+,23-,24-/m1/s1

Hyodeoxycholic acid is a secondary bile acid. It is produced from lithocholic acid by bacterial action in the colon. Dietary supplementation with HDCA results in decreased plasma VLDL and LDL cholesterol and reduced atherosclerosis in mice. Serum levels of HDCA are increased significantly in Crohn’s disease and ulcerative colitis. Hyodeoxycholic acid can be used as a building block/ precursor for steroid synthesis.

Artikelnummer: H0198 Kategorie: Lipids, Fatty Acids

Zusätzliche Informationen

Zusätzliche Informationen

Synonyms	HDCA, 3α,6α-Dihydroxy-5β-cholan-24-oic acid, NSC 60672, BRN 3218394, Iodeoxycholic acid
Purity	≥98% (HPLC)
Appearance	White powder
CAS-Number	83-49-8
Molecular Formula	C24H40O4
Molecular Weight	392.57
Identity	1H-NMR
Solvents	DMSO (20 mg/ml), DMF (30 mg/ml), ethanol (20 mg/ml)
Smiles	O[C@@H]1CC[C@@]2(C)[C@@]([C@@H](O)C[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@@H](CCC(O)=O)C)([H])C1
InChi Key	DGABKXLVXPYZII-SIBKNCMHSA-N
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at -20°C.
Transportation	Not dangerous goods
References	(1) W.Z. Chow & D.C. Huang, Sci. Sin. 14, 1083 (1965), (2) K. Einarsson, J. Biol. Chem. 241, 534 (1966), (3) K. Ochi, et al., Steroids 30, 795 (1977), (4) K.R. Bharucha, Steroids 32, 589 (1978), (5) C.K. McSherry, et al., Am. J. Surg. 149, 126 (1985), (6) E. Sehayek, et al., J. Lipid Res. 42, 1250 (2001), (7) C. Gnewuch, et al., World J. Gastroenterol. 15, 3134 (2009), (8) D.M. Shih, et al., FASEB J. 27, 3805 (2013), (9) S. Watanabe & K. Fujita, Lipids 49, 963 (2014)
InChi	InChI=1S/C24H40O4/c1-14(4-7-22(27)28)17-5-6-18-16-13-21(26)20-12-15(25)8-10-24(20,3)19(16)9-11-23(17,18)2/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16+,17-,18+,19+,20+,21+,23-,24-/m1/s1
Quantity	10 g, Bulk