Available from stock

Indocyanine green

SKU: I0013

Category: Non Fluorescent Detection & Chromogene Detection

Synonyms: Cardiogreen , Foxgreen , IC Green , Ujoviridin , ICG; 3599-32-4
CAS-Number: C₄₃H₄₇N₂NaO₆S₂
Molecular Formula: 774.98
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Appearance: Dark-green to black powder
Identity: 1H-NMR

Properties

Solvents: DMSO (10 mg/ml). Slighlty ethanol or water (1 mg/ml).
UV / Vis: λmax 779-789 nm in methanol

Shipping: AMBIENT
Short Term Storage: +4°C
Long Term Storage: -20°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at -20°C.

Hazard statements: H315-H319-H335
Precautionary statements: P261-P305 + P351 + P338
GHS Symbol: GHS07
Signal word: Warning
Transportation: Not dangerous goods

Description: Indocyanine green (ICG) is a cyanine dye. It is a clinically approved near infrared (NIR) fluorescent dye and used in medical diagnostics, in vitro, in vivo and animal model study. NIR fluorescence is being utilized in a wide range of research fields. ICG is a vital fluorescent dye that binds to plasma proteins and lipoproteins. It displays excitation maxima ranging from 750 to 800 nm and an emission maximum of greater than or equal to 800 nm, which shifts from 810-820 nm in aqueous solution to 820-834 nm following intravenous injection. Formulations containing indocyanine green have been commonly used in clinical and surgical applications, including retinal angiography, intraocular surgery, and cardiac output and liver condition monitoring. ICG might be excited using 750-800 nm laser line or LED and displays excellent optical properties. ICG has a half-life of 150 to 180 seconds and is removed from circulation exclusively by the liver. Spectral Data: Ex/Em = 785/812 nm. Extinction coefficient: >220,000 cm-1M-1. CF280: 0.05.
Smiles: O=S(CCCCN(C(C=CC1=C2C=CC=C1)=C2C/3(C)C)C3=C/C=C/C=C/C=C/C4=[N+](CCCCS(=O)([O-])=O)C(C=CC5=C6C=CC=C5)=C6C4(C)C)([O-])=O.[Na+]
InChi Key: MOFVSTNWEDAEEK-UHFFFAOYSA-M
References: (1) T. Desmettre, et al., Surv. Ophthalmol. 45, 15 (2000) (Review) , (2) M.C. Morales, et al., Invest. Ophthalmol. Vis. Sci. 51, 6018 (2010) , (3) B.E. Schaafsma, et al., J. Surg. Oncol. 104, 323 (2011) (Review) , (4) K. Polom, et al., Cancer 117, 4812 (2011) (Review) , (5) J.T. Alander, et al., Int. J. Biomed. Imaging 2012, 940585 (2012) (Review) , (6) N. Kokudo & T. Ishizawa, Liver Cancer 1, 15 (2012) (Review) , (7) C. Giraudeau, et al., Curr. Med. Chem. 21, 1871 (2014) (Review) , (8) J.A. Zelken & A.P. Tufaro, Ann. Surg. Oncol. 22, S1271 (2015) (Review) , (9) M.B. Reinhart, et al., Surg. Innov. 23, 166 (2016) (Review) , (10) C. Egloff-Juras, et al., Int. J. Nanomedicine 14, 7823 (2019) (Review) , (11) E. Spartalis, et al., In Vivo 34, 23 (2020) (Review)
InChi: InChI=1S/C43H48N2O6S2.Na/c1-42(2)38(44(28-14-16-30-52(46,47)48)36-26-24-32-18-10-12-20-34(32)40(36)42)22-8-6-5-7-9-23-39-43(3,4)41-35-21-13-11-19-33(35)25-27-37(41)45(39)29-15-17-31-53(49,50)51;/h5-13,18-27H,14-17,28-31H2,1-4H3,(H-,46,47,48,49,50,51);/q;+1/p-1

Indocyanine green (ICG) is a cyanine dye. It is a clinically approved near infrared (NIR) fluorescent dye and used in medical diagnostics, in vitro, in vivo and animal model study. NIR fluorescence is being utilized in a wide range of research fields. ICG is a vital fluorescent dye that binds to plasma proteins and lipoproteins. It displays excitation maxima ranging from 750 to 800 nm and an emission maximum of greater than or equal to 800 nm, which shifts from 810-820 nm in aqueous solution to 820-834 nm following intravenous injection. Formulations containing indocyanine green have been commonly used in clinical and surgical applications, including retinal angiography, intraocular surgery, and cardiac output and liver condition monitoring. ICG might be excited using 750-800 nm laser line or LED and displays excellent optical properties. ICG has a half-life of 150 to 180 seconds and is removed from circulation exclusively by the liver. Spectral Data: Ex/Em = 785/812 nm. Extinction coefficient: >220,000 cm-1M-1. CF280: 0.05.

SKU: I0013 Category: Non Fluorescent Detection & Chromogene Detection

Additional information

Additional information

Synonyms	Cardiogreen, Foxgreen, IC Green, Ujoviridin, ICG
Purity	≥98% (HPLC)
Appearance	Dark-green to black powder
CAS-Number	3599-32-4
Molecular Formula	C43H47N2NaO6S2
Molecular Weight	774.98
Identity	1H-NMR
Solvents	DMSO (10 mg/ml). Slighlty ethanol or water (1 mg/ml).
UV / Vis	λmax 779-789 nm in methanol
Smiles	O=S(CCCCN(C(C=CC1=C2C=CC=C1)=C2C/3(C)C)C3=C/C=C/C=C/C=C/C4=[N+](CCCCS(=O)([O-])=O)C(C=CC5=C6C=CC=C5)=C6C4(C)C)([O-])=O.[Na+]
InChi Key	MOFVSTNWEDAEEK-UHFFFAOYSA-M
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at -20°C.
Hazard statements	H315-H319-H335
Precautionary statements	P261-P305 + P351 + P338
GHS Symbol	GHS07
Signal word	Warning
Transportation	Not dangerous goods
References	(1) T. Desmettre, et al., Surv. Ophthalmol. 45, 15 (2000) (Review), (2) M.C. Morales, et al., Invest. Ophthalmol. Vis. Sci. 51, 6018 (2010), (3) B.E. Schaafsma, et al., J. Surg. Oncol. 104, 323 (2011) (Review), (4) K. Polom, et al., Cancer 117, 4812 (2011) (Review), (5) J.T. Alander, et al., Int. J. Biomed. Imaging 2012, 940585 (2012) (Review), (6) N. Kokudo & T. Ishizawa, Liver Cancer 1, 15 (2012) (Review), (7) C. Giraudeau, et al., Curr. Med. Chem. 21, 1871 (2014) (Review), (8) J.A. Zelken & A.P. Tufaro, Ann. Surg. Oncol. 22, S1271 (2015) (Review), (9) M.B. Reinhart, et al., Surg. Innov. 23, 166 (2016) (Review), (10) C. Egloff-Juras, et al., Int. J. Nanomedicine 14, 7823 (2019) (Review), (11) E. Spartalis, et al., In Vivo 34, 23 (2020) (Review)
InChi	InChI=1S/C43H48N2O6S2.Na/c1-42(2)38(44(28-14-16-30-52(46,47)48)36-26-24-32-18-10-12-20-34(32)40(36)42)22-8-6-5-7-9-23-39-43(3,4)41-35-21-13-11-19-33(35)25-27-37(41)45(39)29-15-17-31-53(49,50)51;/h5-13,18-27H,14-17,28-31H2,1-4H3,(H-,46,47,48,49,50,51);/q;+1/p-1
Quantity	100 mg, 500 mg, Bulk