Isoorientin

SKU: I0095

Category: Carbohydrates

Synonyms: Homoorientin , Luteolin 6-C-β-D-glucoside , Luteolin 6-C-glucoside , Lespecapitioside; 4261-42-1
CAS-Number: C₂₁H₂₀O₁₁
Molecular Formula: 448.38
Molecular Weight

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Identity: 1H-NMR
Appearance: Yellow powder

Properties

Solvents: DMSO (15 mg/ml), DMF (15 mg/ml), methanol (5 mg/ml)

Short Term Storage: RT
Use / Stability: Stable for at least 2 years after receipt when stored at +4°C.
Handling Advice: Protect from light and moisture.
Long Term Storage: +4°C
Shipping: AMBIENT

Transportation: Not dangerous goods

Description: Isoorientin is a flavonoid with various biological properties. It has anticancer, antioxidant, anti-inflammatory, antimicrobial, gastroprotective and antinociceptive activities. It induces apoptosis in and reduces cell viability of cancer cells. It is a selective Cyclooxygenase-2 (COX-2) inhibitor. Reduces expression of COX-2, IL-6, 5-lipoxygenase (5-LO), and TNF-α in RAW 264.7 cells. It also has shown to regulate lipid metabolism.
References: (1) M. Sumalatha, et al., Nat. Prod. Commun. 10, 1703 (2015) , (2) L. Yuan, et al., J. Agric. Food Chem. 64, 2682 (2016) , (3) X. Lin, et al., J. Ethnopharmacol. 187, 187 (2016) , (4) L. Yuan, et al., Biomed. Pharmacother. 81, 356 (2016) , (5) T. Ye, et al., Onco. Targets Ther. 9, 7481 (2016) , (6) K. Anilkumar, et al., Oxid. Med. Cell. Longev. 2017, 5498054 (2017) , (7) E.S. Karaoglan, et al., Acta. Cir. Bras. 33, 609 (2018) , (8) L. Yuan, et al., J. Agric. Food Chem. 66, 9777 (2018) , (9) G. Zhang, et al., Int. Immunopharmacol. 75, 105753 (2019)
InChi Key: ODBRNZZJSYPIDI-VJXVFPJBSA-N
Smiles: OC(C(C(C=C(C1=CC(O)=C(O)C=C1)O2)=O)=C2C=C3O)=C3[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4

Isoorientin is a flavonoid with various biological properties. It has anticancer, antioxidant, anti-inflammatory, antimicrobial, gastroprotective and antinociceptive activities. It induces apoptosis in and reduces cell viability of cancer cells. It is a selective Cyclooxygenase-2 (COX-2) inhibitor. Reduces expression of COX-2, IL-6, 5-lipoxygenase (5-LO), and TNF-α in RAW 264.7 cells. It also has shown to regulate lipid metabolism.

Artikelnummer: I0095 Kategorie: Carbohydrates

Zusätzliche Information

Zusätzliche Information

Synonyms	Homoorientin, Luteolin 6-C-β-D-glucoside, Luteolin 6-C-glucoside, Lespecapitioside
Purity	≥98% (HPLC)
Appearance	Yellow powder
CAS-Number	4261-42-1
Molecular Formula	C21H20O11
Molecular Weight	448.38
Identity	1H-NMR
Solvents	DMSO (15 mg/ml), DMF (15 mg/ml), methanol (5 mg/ml)
Smiles	OC(C(C(C=C(C1=CC(O)=C(O)C=C1)O2)=O)=C2C=C3O)=C3[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4
InChi Key	ODBRNZZJSYPIDI-VJXVFPJBSA-N
Shipping	AMBIENT
Short Term Storage	RT
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at +4°C.
Transportation	Not dangerous goods
References	(1) M. Sumalatha, et al., Nat. Prod. Commun. 10, 1703 (2015), (2) L. Yuan, et al., J. Agric. Food Chem. 64, 2682 (2016), (3) X. Lin, et al., J. Ethnopharmacol. 187, 187 (2016), (4) L. Yuan, et al., Biomed. Pharmacother. 81, 356 (2016), (5) T. Ye, et al., Onco. Targets Ther. 9, 7481 (2016), (6) K. Anilkumar, et al., Oxid. Med. Cell. Longev. 2017, 5498054 (2017), (7) E.S. Karaoglan, et al., Acta. Cir. Bras. 33, 609 (2018), (8) L. Yuan, et al., J. Agric. Food Chem. 66, 9777 (2018), (9) G. Zhang, et al., Int. Immunopharmacol. 75, 105753 (2019)
Quantity	1 mg, 5 mg, 10 mg, Bulk