Available from stock

Isoorientin

SKU: I0095

Category: Carbohydrates

Synonyms: Homoorientin , Luteolin 6-C-β-D-glucoside , Luteolin 6-C-glucoside , Lespecapitioside; 4261-42-1
CAS-Number: C₂₁H₂₀O₁₁
Molecular Formula: 448.38
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Appearance: Yellow powder
Identity: 1H-NMR

Properties

Solvents: DMSO (15 mg/ml), DMF (15 mg/ml), methanol (5 mg/ml)

Shipping: AMBIENT
Short Term Storage: RT
Long Term Storage: +4°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at +4°C.

Transportation: Not dangerous goods

Description: Isoorientin is a flavonoid with various biological properties. It has anticancer, antioxidant, anti-inflammatory, antimicrobial, gastroprotective and antinociceptive activities. It induces apoptosis in and reduces cell viability of cancer cells. It is a selective Cyclooxygenase-2 (COX-2) inhibitor. Reduces expression of COX-2, IL-6, 5-lipoxygenase (5-LO), and TNF-α in RAW 264.7 cells. It also has shown to regulate lipid metabolism.
Smiles: OC(C(C(C=C(C1=CC(O)=C(O)C=C1)O2)=O)=C2C=C3O)=C3[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4
InChi Key: ODBRNZZJSYPIDI-VJXVFPJBSA-N
References: (1) M. Sumalatha, et al., Nat. Prod. Commun. 10, 1703 (2015) , (2) L. Yuan, et al., J. Agric. Food Chem. 64, 2682 (2016) , (3) X. Lin, et al., J. Ethnopharmacol. 187, 187 (2016) , (4) L. Yuan, et al., Biomed. Pharmacother. 81, 356 (2016) , (5) T. Ye, et al., Onco. Targets Ther. 9, 7481 (2016) , (6) K. Anilkumar, et al., Oxid. Med. Cell. Longev. 2017, 5498054 (2017) , (7) E.S. Karaoglan, et al., Acta. Cir. Bras. 33, 609 (2018) , (8) L. Yuan, et al., J. Agric. Food Chem. 66, 9777 (2018) , (9) G. Zhang, et al., Int. Immunopharmacol. 75, 105753 (2019)

Isoorientin is a flavonoid with various biological properties. It has anticancer, antioxidant, anti-inflammatory, antimicrobial, gastroprotective and antinociceptive activities. It induces apoptosis in and reduces cell viability of cancer cells. It is a selective Cyclooxygenase-2 (COX-2) inhibitor. Reduces expression of COX-2, IL-6, 5-lipoxygenase (5-LO), and TNF-α in RAW 264.7 cells. It also has shown to regulate lipid metabolism.

SKU: I0095 Category: Carbohydrates

Additional information

Additional information

Synonyms	Homoorientin, Luteolin 6-C-β-D-glucoside, Luteolin 6-C-glucoside, Lespecapitioside
Purity	≥98% (HPLC)
Appearance	Yellow powder
CAS-Number	4261-42-1
Molecular Formula	C21H20O11
Molecular Weight	448.38
Identity	1H-NMR
Solvents	DMSO (15 mg/ml), DMF (15 mg/ml), methanol (5 mg/ml)
Smiles	OC(C(C(C=C(C1=CC(O)=C(O)C=C1)O2)=O)=C2C=C3O)=C3[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4
InChi Key	ODBRNZZJSYPIDI-VJXVFPJBSA-N
Shipping	AMBIENT
Short Term Storage	RT
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at +4°C.
Transportation	Not dangerous goods
References	(1) M. Sumalatha, et al., Nat. Prod. Commun. 10, 1703 (2015), (2) L. Yuan, et al., J. Agric. Food Chem. 64, 2682 (2016), (3) X. Lin, et al., J. Ethnopharmacol. 187, 187 (2016), (4) L. Yuan, et al., Biomed. Pharmacother. 81, 356 (2016), (5) T. Ye, et al., Onco. Targets Ther. 9, 7481 (2016), (6) K. Anilkumar, et al., Oxid. Med. Cell. Longev. 2017, 5498054 (2017), (7) E.S. Karaoglan, et al., Acta. Cir. Bras. 33, 609 (2018), (8) L. Yuan, et al., J. Agric. Food Chem. 66, 9777 (2018), (9) G. Zhang, et al., Int. Immunopharmacol. 75, 105753 (2019)
Quantity	1 mg, 5 mg, 10 mg, Bulk