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    Medetomidine hydrochloride

    Available from stock

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      Medetomidine hydrochloride

      SKU
      M0559

      Category: API's & Intermediates

      Synonyms
      4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride , Domitor , MPV 785 , Metomidine , Zalopine , Detomidine HCl
      86347-15-1
      CAS-Number
      C13H17ClN2
      Molecular Formula
      236.75
      Molecular Weight

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥98%
      Identity
      1H-NMR
      Appearance
      White to off-white powder

      Properties

      Solvents
      water (20 mg/ml), DMSO (20 mg/ml)
      Handling Advice
      Protect from light and moisture.
      Use / Stability
      Stable for at least 2 years after receipt when stored at -20°C.
      Long Term Storage
      -20°C
      Short Term Storage
      +4°C
      Shipping
      AMBIENT
      Transportation
      Not dangerous goods
      Signal word
      Warning
      GHS Symbol
      GHS07
      Precautionary statements
      P261, P305+P351+P338, P302+P352
      Hazard statements
      H315, H319, H335
      Description
      Medetomidine is an imidazole derivative. It acts as a potent selective agonist of α2-adrenoceptors (Ki=1.08nM vs. 1750nM for α1-adrenoceptors). Through its effect on α2-adrenoceptors, medetomidine has sedative, antinociceptive, hypotenisve, bradycardic, anxiolytic, analgesic and hypothermic actions. Its effects on pain are additive or synergistic with fentanyl-type opioids. The effects of medetomidine are effectively countered by α2-adrenoceptor antagonists, like atipamezole. Selective α2-adrenoceptor agonists, including medetomidine, have anesthetic sparing properties, greatly reducing the dose of anesthetic required following premedication with the α2-adrenoceptor agonist.
      References
      (1) J.M. Savola, et al., J. Auton. Pharmacol. 6, 275 (1986) , (2) R. Virtanen, et al., Eur. J. Pharmacol. 150, 9 (1988) , (3) M.H. Ossipov, et al., Anesthesiology 73, 1227 (1990) , (4) T.F. Meert, & M. de Kock, Anesthesiology 81, 677 (1994) , (5) J.C. Hunter, et al., Br. J. Pharmacol. 122, 1339 (1997) , (6) H. Scheinin, et al., Anesthesiology 89, 574 (1998) , (7) M.D. Sinclair, Can. Vet. J. 44, 885 (2003)
      InChi Key
      VPNGEIHDPSLNMU-UHFFFAOYSA-N
      Smiles
      CC1=CC=CC(C(C)C2=CNC=N2)=C1C.Cl

      Medetomidine is an imidazole derivative. It acts as a potent selective agonist of α2-adrenoceptors (Ki=1.08nM vs. 1750nM for α1-adrenoceptors). Through its effect on α2-adrenoceptors, medetomidine has sedative, antinociceptive, hypotenisve, bradycardic, anxiolytic, analgesic and hypothermic actions. Its effects on pain are additive or synergistic with fentanyl-type opioids. The effects of medetomidine are effectively countered by α2-adrenoceptor antagonists, like atipamezole. Selective α2-adrenoceptor agonists, including medetomidine, have anesthetic sparing properties, greatly reducing the dose of anesthetic required following premedication with the α2-adrenoceptor agonist.

      Artikelnummer: M0559 Kategorie: API's & Intermediates
      • Zusätzliche Information

      Zusätzliche Information

      Synonyms

      4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride, Domitor, MPV 785, Metomidine, Zalopine, Detomidine HCl

      Purity

      ≥98%

      Appearance

      White to off-white powder

      CAS-Number

      86347-15-1

      Molecular Formula

      C13H17ClN2

      Molecular Weight

      236.75

      Identity

      1H-NMR

      Solvents

      water (20 mg/ml), DMSO (20 mg/ml)

      Smiles

      CC1=CC=CC(C(C)C2=CNC=N2)=C1C.Cl

      InChi Key

      VPNGEIHDPSLNMU-UHFFFAOYSA-N

      Shipping

      AMBIENT

      Short Term Storage

      +4°C

      Long Term Storage

      -20°C

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at -20°C.

      Hazard statements

      H315, H319, H335

      Precautionary statements

      P261, P305+P351+P338, P302+P352

      GHS Symbol

      GHS07

      Signal word

      Warning

      Transportation

      Not dangerous goods

      References

      (1) J.M. Savola, et al., J. Auton. Pharmacol. 6, 275 (1986), (2) R. Virtanen, et al., Eur. J. Pharmacol. 150, 9 (1988), (3) M.H. Ossipov, et al., Anesthesiology 73, 1227 (1990), (4) T.F. Meert, & M. de Kock, Anesthesiology 81, 677 (1994), (5) J.C. Hunter, et al., Br. J. Pharmacol. 122, 1339 (1997), (6) H. Scheinin, et al., Anesthesiology 89, 574 (1998), (7) M.D. Sinclair, Can. Vet. J. 44, 885 (2003)

      Quantity

      10 mg, 50 mg, Bulk

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