Specifications
- Purity
- ≥98%
- Identity
- 1H-NMR
- Appearance
- White to off-white powder
Properties
- Solvents
- water (20 mg/ml), DMSO (20 mg/ml)
Category: API's & Intermediates
Medetomidine is an imidazole derivative. It acts as a potent selective agonist of α2-adrenoceptors (Ki=1.08nM vs. 1750nM for α1-adrenoceptors). Through its effect on α2-adrenoceptors, medetomidine has sedative, antinociceptive, hypotenisve, bradycardic, anxiolytic, analgesic and hypothermic actions. Its effects on pain are additive or synergistic with fentanyl-type opioids. The effects of medetomidine are effectively countered by α2-adrenoceptor antagonists, like atipamezole. Selective α2-adrenoceptor agonists, including medetomidine, have anesthetic sparing properties, greatly reducing the dose of anesthetic required following premedication with the α2-adrenoceptor agonist.
Synonyms | 4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride, Domitor, MPV 785, Metomidine, Zalopine, Detomidine HCl |
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Purity | ≥98% |
Appearance | White to off-white powder |
CAS-Number | 86347-15-1 |
Molecular Formula | C13H17ClN2 |
Molecular Weight | 236.75 |
Identity | 1H-NMR |
Solvents | water (20 mg/ml), DMSO (20 mg/ml) |
Smiles | CC1=CC=CC(C(C)C2=CNC=N2)=C1C.Cl |
InChi Key | VPNGEIHDPSLNMU-UHFFFAOYSA-N |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Hazard statements | H315, H319, H335 |
Precautionary statements | P261, P305+P351+P338, P302+P352 |
GHS Symbol | GHS07 |
Signal word | Warning |
Transportation | Not dangerous goods |
References | (1) J.M. Savola, et al., J. Auton. Pharmacol. 6, 275 (1986), (2) R. Virtanen, et al., Eur. J. Pharmacol. 150, 9 (1988), (3) M.H. Ossipov, et al., Anesthesiology 73, 1227 (1990), (4) T.F. Meert, & M. de Kock, Anesthesiology 81, 677 (1994), (5) J.C. Hunter, et al., Br. J. Pharmacol. 122, 1339 (1997), (6) H. Scheinin, et al., Anesthesiology 89, 574 (1998), (7) M.D. Sinclair, Can. Vet. J. 44, 885 (2003) |
Quantity | 10 mg, 50 mg, Bulk |