Medetomidine hydrochloride

SKU: M0559

Category: API's & Intermediates

Synonyms: 4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride , Domitor , MPV 785 , Metomidine , Zalopine , Detomidine HCl; 86347-15-1
CAS-Number: C₁₃H₁₇ClN₂
Molecular Formula: 236.75
Molecular Weight

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98%
Identity: 1H-NMR
Appearance: White to off-white powder

Properties

Solvents: water (20 mg/ml), DMSO (20 mg/ml)

Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at -20°C.
Long Term Storage: -20°C
Short Term Storage: +4°C
Shipping: AMBIENT

Transportation: Not dangerous goods
Signal word: Warning
GHS Symbol: GHS07
Precautionary statements: P261, P305+P351+P338, P302+P352
Hazard statements: H315, H319, H335

Description: Medetomidine is an imidazole derivative. It acts as a potent selective agonist of α2-adrenoceptors (Ki=1.08nM vs. 1750nM for α1-adrenoceptors). Through its effect on α2-adrenoceptors, medetomidine has sedative, antinociceptive, hypotenisve, bradycardic, anxiolytic, analgesic and hypothermic actions. Its effects on pain are additive or synergistic with fentanyl-type opioids. The effects of medetomidine are effectively countered by α2-adrenoceptor antagonists, like atipamezole. Selective α2-adrenoceptor agonists, including medetomidine, have anesthetic sparing properties, greatly reducing the dose of anesthetic required following premedication with the α2-adrenoceptor agonist.
References: (1) J.M. Savola, et al., J. Auton. Pharmacol. 6, 275 (1986) , (2) R. Virtanen, et al., Eur. J. Pharmacol. 150, 9 (1988) , (3) M.H. Ossipov, et al., Anesthesiology 73, 1227 (1990) , (4) T.F. Meert, & M. de Kock, Anesthesiology 81, 677 (1994) , (5) J.C. Hunter, et al., Br. J. Pharmacol. 122, 1339 (1997) , (6) H. Scheinin, et al., Anesthesiology 89, 574 (1998) , (7) M.D. Sinclair, Can. Vet. J. 44, 885 (2003)
InChi Key: VPNGEIHDPSLNMU-UHFFFAOYSA-N
Smiles: CC1=CC=CC(C(C)C2=CNC=N2)=C1C.Cl

Medetomidine is an imidazole derivative. It acts as a potent selective agonist of α2-adrenoceptors (Ki=1.08nM vs. 1750nM for α1-adrenoceptors). Through its effect on α2-adrenoceptors, medetomidine has sedative, antinociceptive, hypotenisve, bradycardic, anxiolytic, analgesic and hypothermic actions. Its effects on pain are additive or synergistic with fentanyl-type opioids. The effects of medetomidine are effectively countered by α2-adrenoceptor antagonists, like atipamezole. Selective α2-adrenoceptor agonists, including medetomidine, have anesthetic sparing properties, greatly reducing the dose of anesthetic required following premedication with the α2-adrenoceptor agonist.

Artikelnummer: M0559 Kategorie: API's & Intermediates

Zusätzliche Information

Zusätzliche Information

Synonyms	4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride, Domitor, MPV 785, Metomidine, Zalopine, Detomidine HCl
Purity	≥98%
Appearance	White to off-white powder
CAS-Number	86347-15-1
Molecular Formula	C13H17ClN2
Molecular Weight	236.75
Identity	1H-NMR
Solvents	water (20 mg/ml), DMSO (20 mg/ml)
Smiles	CC1=CC=CC(C(C)C2=CNC=N2)=C1C.Cl
InChi Key	VPNGEIHDPSLNMU-UHFFFAOYSA-N
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at -20°C.
Hazard statements	H315, H319, H335
Precautionary statements	P261, P305+P351+P338, P302+P352
GHS Symbol	GHS07
Signal word	Warning
Transportation	Not dangerous goods
References	(1) J.M. Savola, et al., J. Auton. Pharmacol. 6, 275 (1986), (2) R. Virtanen, et al., Eur. J. Pharmacol. 150, 9 (1988), (3) M.H. Ossipov, et al., Anesthesiology 73, 1227 (1990), (4) T.F. Meert, & M. de Kock, Anesthesiology 81, 677 (1994), (5) J.C. Hunter, et al., Br. J. Pharmacol. 122, 1339 (1997), (6) H. Scheinin, et al., Anesthesiology 89, 574 (1998), (7) M.D. Sinclair, Can. Vet. J. 44, 885 (2003)
Quantity	10 mg, 50 mg, Bulk