Specifications
- Purity
- ≥97% (HPLC)
- Identity
- 1H-NMR
- Appearance
- White to off-white powder
Properties
- Solvents
- chloroform, DMSO
Available from stock
N-Pentanoyl-L-homoserine lactone
- SKU
- P0486
Category: Quorum Sensing
- Synonyms
- C5-L-HSL , N-[(3S)-tetrahydro-2-oxo-3-furanyl]-pentanamide
- 148497-11-4
- CAS-Number
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at -20°C.
- Long Term Storage
- -20°C
- Short Term Storage
- +4°C
- Shipping
- AMBIENT
- Transportation
- Not dangerous goods
- Signal word
- Warning
- GHS Symbol
- GHS07
- Hazard statements
- H302
- Description
- N-Pentanoyl-L-homoserine lactone is a small diffusible signaling molecule and is a member of N-acyl-homoserine lactone family. N-acylhomoserine lactones (AHL) are involved in quorum sensing, controlling gene expression, and cellular metabolism. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Regulation of bacterial quorum sensing signaling systems to inhibit pathogenesis represents a new approach to antimicrobial therapy in the treatment of infectious diseases.
- References
- (1) S.R. Chhabra, et al., J. Antibiot. 46, 441 (1993) , (2) A.L. Schaefer, et al., J. Bacteriol. 178, 2897 (1996) , (3) J. Zhu, et al., Appl. Environ. Microbiol. 69, 6949 (2003) , (4) C.L. Weingart, et al., Mol. Microbiol. 57, 452 (2005) , (5) W.-K. Goh, et al., Molecules 10, 1263 (2005) , (6) X. Liu, et al., BMC Microbiol. 11, 26 (2011)
- InChi Key
- BFIMURGDHGARTN-ZETCQYMHSA-N
- Smiles
- O=C1[C@@H](NC(CCCC)=O)CCO1
N-Pentanoyl-L-homoserine lactone is a small diffusible signaling molecule and is a member of N-acyl-homoserine lactone family. N-acylhomoserine lactones (AHL) are involved in quorum sensing, controlling gene expression, and cellular metabolism. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Regulation of bacterial quorum sensing signaling systems to inhibit pathogenesis represents a new approach to antimicrobial therapy in the treatment of infectious diseases.
Zusätzliche Information
| Synonyms | C5-L-HSL, N-[(3S)-tetrahydro-2-oxo-3-furanyl]-pentanamide |
|---|---|
| Purity | ≥97% (HPLC) |
| Appearance | White to off-white powder |
| CAS-Number | 148497-11-4 |
| Identity | 1H-NMR |
| Solvents | chloroform, DMSO |
| Smiles | O=C1[C@@H](NC(CCCC)=O)CCO1 |
| InChi Key | BFIMURGDHGARTN-ZETCQYMHSA-N |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Hazard statements | H302 |
| GHS Symbol | GHS07 |
| Signal word | Warning |
| Transportation | Not dangerous goods |
| References | (1) S.R. Chhabra, et al., J. Antibiot. 46, 441 (1993), (2) A.L. Schaefer, et al., J. Bacteriol. 178, 2897 (1996), (3) J. Zhu, et al., Appl. Environ. Microbiol. 69, 6949 (2003), (4) C.L. Weingart, et al., Mol. Microbiol. 57, 452 (2005), (5) W.-K. Goh, et al., Molecules 10, 1263 (2005), (6) X. Liu, et al., BMC Microbiol. 11, 26 (2011) |
| Quantity | 10 mg, 50 mg, Bulk |
