Specifications
- Purity
- ≥98% (GC)
- Identity
- 1H-NMR
- Appearance
- White to off-white powder
- Solubility
- 50 mg in 1 ml DMF (clear to very slight hazy)
Properties
- Solvents
- DMSO (20 mg/ml) or DMF.
Available from stock
Nadolol
- SKU
- N0141
Category: API's & Intermediates
- Synonyms
- Corgard , SQ11725
- 42200-33-9
- CAS-Number
- C17H27NO4
- Molecular Formula
- 309.40
- Molecular Weight
- Long Term Storage
- -20°C
- Use / Stability
- Stable for at least 2 years after receipt when stored at -20°C.
- Handling Advice
- Protect from light and moisture.
- Short Term Storage
- +4°C
- Shipping
- AMBIENT
- Transportation
- Not dangerous goods
- Description
- Nadolol is a polar and hydrophilic, non-selective beta-adrenergic antagonist with antihypertensive and antiarrhythmic activities. It is a long-acting beta-blocker, which displays activity against beta-1 and beta-2 receptors. It has a preference for beta-1 receptors, which are predominantly located in the heart, thereby inhibiting the effects of catecholamines and causing a decrease in heart rate and blood pressure. Nadolol's inhibition of beta-1 receptors in the heart and kidney leads to its effects on lowering blood pressure. Its inhibition of beta-2 receptors, which are mainly located in the bronchial smooth muscle of the airways, leads to airway constriction similar to that seen in asthma.
- InChi
- InChI=1S/C17H27NO4/c1-17(2,3)18-9-12(19)10-22-16-6-4-5-11-7-14(20)15(21)8-13(11)16/h4-6,12,14-15,18-21H,7-10H2,1-3H3/t12?,14-,15+/m1/s1
- References
- (1) D.B. Evans, et al., Eur. J. Pharmacol. 35, 17 (1976) , (2) W. Frishman, Am. Heart J. 99, 124 (1980) (Review) , (3) R.C. Heel, et al., Drugs 20, 1 (1980) (Review) , (4) W.H. Frishman, N. Engl. J. Med. 305, 678 (1981) (Review) , (5) H. Peng, et al., 383, 209 (2011)
- InChi Key
- VWPOSFSPZNDTMJ-UCWKZMIHSA-N
- Smiles
- O[C@H]1[C@@H](O)CC2=C(OCC(O)CNC(C)(C)C)C=CC=C2C1
Nadolol is a polar and hydrophilic, non-selective beta-adrenergic antagonist with antihypertensive and antiarrhythmic activities. It is a long-acting beta-blocker, which displays activity against beta-1 and beta-2 receptors. It has a preference for beta-1 receptors, which are predominantly located in the heart, thereby inhibiting the effects of catecholamines and causing a decrease in heart rate and blood pressure. Nadolol’s inhibition of beta-1 receptors in the heart and kidney leads to its effects on lowering blood pressure. Its inhibition of beta-2 receptors, which are mainly located in the bronchial smooth muscle of the airways, leads to airway constriction similar to that seen in asthma.
Zusätzliche Information
| Synonyms | Corgard, SQ11725 |
|---|---|
| Purity | ≥98% (GC) |
| Appearance | White to off-white powder |
| CAS-Number | 42200-33-9 |
| Molecular Formula | C17H27NO4 |
| Molecular Weight | 309.40 |
| Identity | 1H-NMR |
| Solvents | DMSO (20 mg/ml) or DMF. |
| Smiles | O[C@H]1[C@@H](O)CC2=C(OCC(O)CNC(C)(C)C)C=CC=C2C1 |
| InChi Key | VWPOSFSPZNDTMJ-UCWKZMIHSA-N |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Transportation | Not dangerous goods |
| References | (1) D.B. Evans, et al., Eur. J. Pharmacol. 35, 17 (1976), (2) W. Frishman, Am. Heart J. 99, 124 (1980) (Review), (3) R.C. Heel, et al., Drugs 20, 1 (1980) (Review), (4) W.H. Frishman, N. Engl. J. Med. 305, 678 (1981) (Review), (5) H. Peng, et al., 383, 209 (2011) |
| InChi | InChI=1S/C17H27NO4/c1-17(2,3)18-9-12(19)10-22-16-6-4-5-11-7-14(20)15(21)8-13(11)16/h4-6,12,14-15,18-21H,7-10H2,1-3H3/t12?,14-,15+/m1/s1 |
| Quantity | 1 g, 5 g, Bulk |
| cdx-Solubility | 50 mg in 1 ml DMF (clear to very slight hazy) |
