- ≥98% (GC)
- White to off-white powder
- 50 mg in 1 ml DMF (clear to very slight hazy)
- DMSO (20 mg/ml) or DMF.
Category: API's & Intermediates
Nadolol is a polar and hydrophilic, non-selective beta-adrenergic antagonist with antihypertensive and antiarrhythmic activities. It is a long-acting beta-blocker, which displays activity against beta-1 and beta-2 receptors. It has a preference for beta-1 receptors, which are predominantly located in the heart, thereby inhibiting the effects of catecholamines and causing a decrease in heart rate and blood pressure. Nadolol’s inhibition of beta-1 receptors in the heart and kidney leads to its effects on lowering blood pressure. Its inhibition of beta-2 receptors, which are mainly located in the bronchial smooth muscle of the airways, leads to airway constriction similar to that seen in asthma.
White to off-white powder
DMSO (20 mg/ml) or DMF.
|Short Term Storage||
|Long Term Storage||
Protect from light and moisture.
|Use / Stability||
Stable for at least 2 years after receipt when stored at -20°C.
Not dangerous goods
(1) D.B. Evans, et al., Eur. J. Pharmacol. 35, 17 (1976), (2) W. Frishman, Am. Heart J. 99, 124 (1980) (Review), (3) R.C. Heel, et al., Drugs 20, 1 (1980) (Review), (4) W.H. Frishman, N. Engl. J. Med. 305, 678 (1981) (Review), (5) H. Peng, et al., 383, 209 (2011)
1 g, 5 g, Bulk
50 mg in 1 ml DMF (clear to very slight hazy)