Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White to off-white powder or crystals
- Identity
- 1H-NMR
Properties
- Solvents
- chloroform, methanol, DCM
- Melting Point
- 92.2 °C
- Optical Activity
- [α]/D 72.0 to 84.0°, c = 0.1 in chloroform
Available from stock
(+)-Naproxen methyl ester
- SKU
- N0557
Category: API's & Intermediates
- Synonyms
- (S)-Naproxen methyl ester, NME, Naproxen Impurity E (PhEur), (2S)-2-(6-Methoxy-2-naphthyl)propionic acid methyl ester, Methyl (2S)-2-(6-Methoxynaphthalen-2-yl)propanoat
- 26159-35-3
- CAS-Number
- C15H16O3
- Molecular Formula
- 244.29
- Molecular Weight
- Shipping
- AMBIENT
- Short Term Storage
- RT
- Long Term Storage
- +4°C
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at +4°C.
- Hazard statements
- H302 - H315 - H319 - H335 - H361fd - H411
- Precautionary statements
- P202 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313
- GHS Symbol
- GHS07+GHS08+GHS09
- Signal word
- Warning
- RIDADR
- UN3077
- Transportation
- Packing Group III
- For Research Use Only
- Not Intended for Diagnostic or Therapeutic Use.
- Description
- The metabolite Naproxen methyl ester (Naproxen Impurity E) is a degradation product from Naproxen which is a non-steroidal anti-inflammatory drug (NSAID) used to in the treatment of pain, menstrual cramps, inflammatory diseases such as rheumatoid arthritis, gout and fever. Ibuprofen is an anti-inflammatory COX inhibitor. This product can be used as a control esterase substrate, as a working standard or secondary analytical reference standard or as an organic building block and intermediate for synthesis.
- Smiles
- C(C(OC)=O)(C)C1=CC2=C(C=C(OC)C=C2)C=C1
- InChi Key
- ZFYFBPCRUQZGJE-UHFFFAOYSA-N
- References
- (1) M. Najlah, et al., Int. J. Pharm. 308, 175 (2006) , (2) H. Weber, et al., Arch. Pharm. 327, 337 (1994) , (3) C.J. Welch, et al., J. High Resol. Chromatogr. 20, 179 (1997) , (4) H. Weber, et al., Pharma. Res. 18, 600 (2001) , (5) J. Krzek & M. Starek, J. Plan. Chromatogr. 17, 137 (2004) , (6) L. Steenkamp & D. Brady, Proc. Biochem. 43, 1419 (2008) , (7) K.C. Duggan, et al., J. Biol. Chem. 285, 34950 (2010) , (8) R.S. Reddy, et al., TACL 6, 55 (2016) , (9) I. Cacciatore, et al., Int. J. Mol. Sci. 17, 1035 (2016) , (10) K. Birgul, et al., Eur. J. Med. Chem. 208, 112841 (2020)
- InChi
- InChI=1S/C15H16O3/c1-10(15(16)18-3)11-4-5-13-9-14(17-2)7-6-12(13)8-11/h4-10H,1-3H3
The metabolite Naproxen methyl ester (Naproxen Impurity E) is a degradation product from Naproxen which is a non-steroidal anti-inflammatory drug (NSAID) used to in the treatment of pain, menstrual cramps, inflammatory diseases such as rheumatoid arthritis, gout and fever. Ibuprofen is an anti-inflammatory COX inhibitor. This product can be used as a control esterase substrate, as a working standard or secondary analytical reference standard or as an organic building block and intermediate for synthesis.
Zusätzliche Informationen
| Synonyms | (S)-Naproxen methyl ester, NME, Naproxen Impurity E (PhEur), (2S)-2-(6-Methoxy-2-naphthyl)propionic acid methyl ester, Methyl (2S)-2-(6-Methoxynaphthalen-2-yl)propanoat |
|---|---|
| Purity | ≥98% (HPLC) |
| Appearance | White to off-white powder or crystals |
| CAS-Number | 26159-35-3 |
| Molecular Formula | C15H16O3 |
| Molecular Weight | 244.29 |
| Identity | 1H-NMR |
| Solvents | chloroform, methanol, DCM |
| Melting Point | 92.2 °C |
| Optical Activity | [α]/D 72.0 to 84.0°, c = 0.1 in chloroform |
| Smiles | C(C(OC)=O)(C)C1=CC2=C(C=C(OC)C=C2)C=C1 |
| InChi Key | ZFYFBPCRUQZGJE-UHFFFAOYSA-N |
| Shipping | AMBIENT |
| Short Term Storage | RT |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Hazard statements | H302 – H315 – H319 – H335 – H361fd – H411 |
| Precautionary statements | P202 – P273 – P301 + P312 – P302 + P352 – P305 + P351 + P338 – P308 + P313 |
| GHS Symbol | GHS07+GHS08+GHS09 |
| Signal word | Warning |
| RIDADR | UN3077 |
| Transportation | Packing Group III |
| References | (1) M. Najlah, et al., Int. J. Pharm. 308, 175 (2006), (2) H. Weber, et al., Arch. Pharm. 327, 337 (1994), (3) C.J. Welch, et al., J. High Resol. Chromatogr. 20, 179 (1997), (4) H. Weber, et al., Pharma. Res. 18, 600 (2001), (5) J. Krzek & M. Starek, J. Plan. Chromatogr. 17, 137 (2004), (6) L. Steenkamp & D. Brady, Proc. Biochem. 43, 1419 (2008), (7) K.C. Duggan, et al., J. Biol. Chem. 285, 34950 (2010), (8) R.S. Reddy, et al., TACL 6, 55 (2016), (9) I. Cacciatore, et al., Int. J. Mol. Sci. 17, 1035 (2016), (10) K. Birgul, et al., Eur. J. Med. Chem. 208, 112841 (2020) |
| InChi | InChI=1S/C15H16O3/c1-10(15(16)18-3)11-4-5-13-9-14(17-2)7-6-12(13)8-11/h4-10H,1-3H3 |
| Quantity | 50 mg, Bulk |
