Specifications
- Appearance
- White to light yellow to brown powder
- Identity
- 1H-NMR
Properties
- Solvents
- Soluble in DMSO (10mg/ml) or ethanol (1mg/ml).
- Melting Point
- 272 - 277 °C
Available from stock
Nequinate
- SKU
- N0674
Category: API's & Intermediates
- Synonyms
- Methyl benzoquate, Neqoinate, Mequinate, AY 20385, ICI 55052, Methyl 7-(benzyloxy)-6-n-butyl-4-oxo-1,4-dihydroquinoline-3-carboxylate
- 13997-19-8
- CAS-Number
- C22H23NO4
- Molecular Formula
- 365.42
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- RT
- Long Term Storage
- RT
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at RT.
- Hazard statements
- H302,H413
- Precautionary statements
- P264 - P270 - P273 - P301 + P312 - P501
- GHS Symbol
- GHS07
- Signal word
- Warning
- Transportation
- Not dangerous goods
- Description
- Nequinate is a quinoline anticoccidial agent against cecal coccidiosis (Eimeria tenella) infections. It is studied for its efficacy against protozoan parasites of the genus Eimeria. The mode of action involves the inhibition of mitochondrial electron transport in the parasites, such as inhibiting xanthine oxidoreductase (XOD) activity, thus disrupting the energy metabolism. Anticoccidial drugs are a class of compounds used to prevent or treat coccidiosis, an intestinal disease caused by protozoan parasites of the genus Eimeria (and occasionally Isospora) in animals, particularly poultry and livestock. Nequinate serves as a reference compound in pharmacological and biochemical studies exploring quinoline-based inhibitors of protozoan metabolism. Compound can be used as analytical reference material.
- Smiles
- O=C1C2=CC(CCCC)=C(OCC3=CC=CC=C3)C=C2NC=C1C(OC)=O
- InChi Key
- NNOPDLNHPOLRRE-UHFFFAOYSA-N
- References
- (1) D.K. McLoughlin & M.B. Chute; Avian Dis. 17, 717 (1973) , (2) G.H. Merson, et al.; Analyst 110, 761 (1985) , (3) R.B. Williams; Int. J. Parasitol. 27, 101 (1997) , (4) Y. Niu, et al.; J. Pharmacol. Sci. 135, 114 (2017) , (5) S. Noack, et al.; Parasitol. Res. 118, 2009 (2019)
- InChi
- InChI=1S/C22H23NO4/c1-3-4-10-16-11-17-19(23-13-18(21(17)24)22(25)26-2)12-20(16)27-14-15-8-6-5-7-9-15/h5-9,11-13H,3-4,10,14H2,1-2H3,(H,23,24)
Nequinate is a quinoline anticoccidial agent against cecal coccidiosis (Eimeria tenella) infections. It is studied for its efficacy against protozoan parasites of the genus Eimeria. The mode of action involves the inhibition of mitochondrial electron transport in the parasites, such as inhibiting xanthine oxidoreductase (XOD) activity, thus disrupting the energy metabolism. Anticoccidial drugs are a class of compounds used to prevent or treat coccidiosis, an intestinal disease caused by protozoan parasites of the genus Eimeria (and occasionally Isospora) in animals, particularly poultry and livestock. Nequinate serves as a reference compound in pharmacological and biochemical studies exploring quinoline-based inhibitors of protozoan metabolism. Compound can be used as analytical reference material.
Additional information
| Synonyms | Methyl benzoquate, Neqoinate, Mequinate, AY 20385, ICI 55052, Methyl 7-(benzyloxy)-6-n-butyl-4-oxo-1,4-dihydroquinoline-3-carboxylate |
|---|---|
| Appearance | White to light yellow to brown powder |
| CAS-Number | 13997-19-8 |
| Molecular Formula | C22H23NO4 |
| Molecular Weight | 365.42 |
| Identity | 1H-NMR |
| Solvents | Soluble in DMSO (10mg/ml) or ethanol (1mg/ml). |
| Melting Point | 272 – 277 °C |
| Smiles | O=C1C2=CC(CCCC)=C(OCC3=CC=CC=C3)C=C2NC=C1C(OC)=O |
| InChi Key | NNOPDLNHPOLRRE-UHFFFAOYSA-N |
| Shipping | AMBIENT |
| Short Term Storage | RT |
| Long Term Storage | RT |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at RT. |
| Hazard statements | H302,H413 |
| Precautionary statements | P264 – P270 – P273 – P301 + P312 – P501 |
| GHS Symbol | GHS07 |
| Signal word | Warning |
| Transportation | Not dangerous goods |
| References | (1) D.K. McLoughlin & M.B. Chute; Avian Dis. 17, 717 (1973), (2) G.H. Merson, et al.; Analyst 110, 761 (1985), (3) R.B. Williams; Int. J. Parasitol. 27, 101 (1997), (4) Y. Niu, et al.; J. Pharmacol. Sci. 135, 114 (2017), (5) S. Noack, et al.; Parasitol. Res. 118, 2009 (2019) |
| InChi | InChI=1S/C22H23NO4/c1-3-4-10-16-11-17-19(23-13-18(21(17)24)22(25)26-2)12-20(16)27-14-15-8-6-5-7-9-15/h5-9,11-13H,3-4,10,14H2,1-2H3,(H,23,24) |
| Quantity | 50 mg, Bulk |
