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    Omeprazole sulfide

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      Omeprazole sulfide

      SKU
      O0041

      Category: API's & Intermediates

      Synonyms
      Omeprazole impurity C (PhEur) , Pyrmetazol , Ufiprazole
      73590-85-9
      CAS-Number
      C17H19N3O2S
      Molecular Formula
      329.42
      Molecular Weight

      For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥97% (NMR)
      Appearance
      White to off-white powder
      Identity
      1H-NMR

      Properties

      Solvents
      DMSO (10 mg/ml), DMF (10 mg/ml), ethanol (10 mg/ml)
      Melting Point
      115-119°C

      Documentation

      Safety Data Sheet (SDS)
      CDX O0041 MSDS.pdf
      Shipping
      AMBIENT
      Short Term Storage
      +4°C
      Long Term Storage
      -20°C
      Handling Advice
      Protect from light and moisture.
      Use / Stability
      Stable for at least 2 years after receipt when stored at -20°C.
      Hazard statements
      H315-H319-H335
      Precautionary statements
      P261-P305 + P351 + P338
      GHS Symbol
      GHS07
      Signal word
      Warning
      Transportation
      Not dangerous goods
      Description
      Omeprazole sulfide is an aryl hydrocarbon receptor (AhR) antagonist. Omeprazole sulfide is an intermediate used in the production of the gastric proton pump inhibitors, omeprazole and esomeprazole. Omeprazole sulfide is also a degradation product (Omeprazole Impurity C) of Omperazole, and it is reported to be a direct-acting inhibitor of cytochrome P450 2C19 in pooled human liver microsomes. Omeprazole is a selective and irreversible proton pump inhibitor. It suppresses stomach acid secretion by specific inhibition of the H+/K+-ATPase system found at the secretory surface of gastric parietal cells. Because this enzyme system is regarded as the acid (proton, or H+) pump within the gastric mucosa, omeprazole inhibits the final step of acid production. Omeprazole sulfide can be usd as reference material.
      Smiles
      CC(C(OC)=C(C)C=N1)=C1CSC2=NC3=CC(OC)=CC=C3N2
      InChi Key
      XURCIPRUUASYLR-UHFFFAOYSA-N
      References
      (1) S. Gerbal-Chaloin, et al., Cell Signal. 18, 740 (2006) , (2) B.W. Ogilvie, e al., Drug Metab. Dispos. 39, 2020 (2011) , (3) L. Olbe, et al., Nat. Rev. Drug Discovery 2, 132 (2003) (Review)
      InChi
      InChI=1S/C17H19N3O2S/c1-10-8-18-15(11(2)16(10)22-4)9-23-17-19-13-6-5-12(21-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)

      Omeprazole sulfide is an aryl hydrocarbon receptor (AhR) antagonist. Omeprazole sulfide is an intermediate used in the production of the gastric proton pump inhibitors, omeprazole and esomeprazole. Omeprazole sulfide is also a degradation product (Omeprazole Impurity C) of Omperazole, and it is reported to be a direct-acting inhibitor of cytochrome P450 2C19 in pooled human liver microsomes. Omeprazole is a selective and irreversible proton pump inhibitor. It suppresses stomach acid secretion by specific inhibition of the H+/K+-ATPase system found at the secretory surface of gastric parietal cells. Because this enzyme system is regarded as the acid (proton, or H+) pump within the gastric mucosa, omeprazole inhibits the final step of acid production. Omeprazole sulfide can be usd as reference material.

      Artikelnummer: O0041 Kategorie: API's & Intermediates
      • Zusätzliche Informationen

      Zusätzliche Informationen

      Synonyms

      Omeprazole impurity C (PhEur), Pyrmetazol, Ufiprazole

      Purity

      ≥97% (NMR)

      Appearance

      White to off-white powder

      CAS-Number

      73590-85-9

      Molecular Formula

      C17H19N3O2S

      Molecular Weight

      329.42

      Identity

      1H-NMR

      Solvents

      DMSO (10 mg/ml), DMF (10 mg/ml), ethanol (10 mg/ml)

      Melting Point

      115-119°C

      Smiles

      CC(C(OC)=C(C)C=N1)=C1CSC2=NC3=CC(OC)=CC=C3N2

      InChi Key

      XURCIPRUUASYLR-UHFFFAOYSA-N

      Shipping

      AMBIENT

      Short Term Storage

      +4°C

      Long Term Storage

      -20°C

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at -20°C.

      Hazard statements

      H315-H319-H335

      Precautionary statements

      P261-P305 + P351 + P338

      GHS Symbol

      GHS07

      Signal word

      Warning

      Transportation

      Not dangerous goods

      References

      (1) S. Gerbal-Chaloin, et al., Cell Signal. 18, 740 (2006), (2) B.W. Ogilvie, e al., Drug Metab. Dispos. 39, 2020 (2011), (3) L. Olbe, et al., Nat. Rev. Drug Discovery 2, 132 (2003) (Review)

      InChi

      InChI=1S/C17H19N3O2S/c1-10-8-18-15(11(2)16(10)22-4)9-23-17-19-13-6-5-12(21-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)

      Quantity

      25 mg, 50 mg, Bulk

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