Procaine hydrochloride

SKU: P0182

Category: Antibiotics

Synonyms: 4-Aminobenzoic acid 2-diethylaminoethyl ester , p-Aminobenzoic acid diethylaminoethyl ester hydrochloride , Novocaine hydrochloride; 51-05-8
CAS-Number: C₁₃H₂₀N₂O₂ HCl
Molecular Formula: 272.77
Molecular Weight

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Identity: 1H-NMR
Appearance: White to off-white powder

Properties

Melting Point: 155-156 °C (lit.)
Solvents: water, ethanol

Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at +4°C.
Long Term Storage: +4°C
Short Term Storage: RT
Shipping: AMBIENT

Transportation: Packing Group III
RIDADR: UN2811 6.1
Signal word: Danger
GHS Symbol: GHS06
Precautionary statements: P280-P301 + P310
Hazard statements: H301-H317

Description: Procaine is a sodium channel blocker, commonly used as an anesthetic agent and a variety of other inhibitiory effects. It is also useful as a painkiller to prevent or relieve pain for short periods, such as during dental procedures. In skeletal muscle, Procaine has been reported to inhibit calcium-induced calcium release (CICR) and to inhibit nicotinic acetylcholine receptors. It has been shown to be a DNA methylation inhibitor with anti-tumor activity. Inhibited also HERG channels. Can be used as an analytical reference compound, since procaine is used as an adulterant in illicit drugs.
References: (1) S. Epstein & N.W. Chilton, Oral Surg. Oral Med. Oral Pathol. 12, 93 (1959) , (2) R. Werdehausen, et al., Br. J. Anaesth. 103, 711 (2009) , (3) Z. Gao, et al., Oncol. Rep. 22, 1479 (2009) , (4) M. Endo, Physiol. Rev. 89, 1153 (2009) , (5) H. Wang, et al., Eur. J. Pharmacol. 630, 29 (2010) , (6) R. Gal & F. Libersat, PLoS ONE 5, e10019 (2010) , (7) C. Cole, et al., CUT (2010) , (8) N. Wang, et al., J. Pharmacol. Sci. 123, 25 (2013) , (9) C. Li, et al., Oncol. Res. 26, 209 (2018) , (10) Y.C. Li, et al., J. Cell Biochem. 119, 2440 (2018)
InChi Key: HCBIBCJNVBAKAB-UHFFFAOYSA-N
Smiles: NC1=CC=C(C(OCC[NH+](CC)CC)=O)C=C1.[Cl-]

Procaine is a sodium channel blocker, commonly used as an anesthetic agent and a variety of other inhibitiory effects. It is also useful as a painkiller to prevent or relieve pain for short periods, such as during dental procedures. In skeletal muscle, Procaine has been reported to inhibit calcium-induced calcium release (CICR) and to inhibit nicotinic acetylcholine receptors. It has been shown to be a DNA methylation inhibitor with anti-tumor activity. Inhibited also HERG channels. Can be used as an analytical reference compound, since procaine is used as an adulterant in illicit drugs.

Artikelnummer: P0182 Kategorie: Antibiotics

Zusätzliche Information

Zusätzliche Information

Synonyms	4-Aminobenzoic acid 2-diethylaminoethyl ester, p-Aminobenzoic acid diethylaminoethyl ester hydrochloride, Novocaine hydrochloride
Purity	≥98% (HPLC)
Appearance	White to off-white powder
CAS-Number	51-05-8
Molecular Formula	C13H20N2O2 HCl
Molecular Weight	272.77
Identity	1H-NMR
Solvents	water, ethanol
Melting Point	155-156 °C (lit.)
Smiles	NC1=CC=C(C(OCC[NH+](CC)CC)=O)C=C1.[Cl-]
InChi Key	HCBIBCJNVBAKAB-UHFFFAOYSA-N
Shipping	AMBIENT
Short Term Storage	RT
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at +4°C.
Hazard statements	H301-H317
Precautionary statements	P280-P301 + P310
GHS Symbol	GHS06
Signal word	Danger
RIDADR	UN2811 6.1
Transportation	Packing Group III
References	(1) S. Epstein & N.W. Chilton, Oral Surg. Oral Med. Oral Pathol. 12, 93 (1959), (2) R. Werdehausen, et al., Br. J. Anaesth. 103, 711 (2009), (3) Z. Gao, et al., Oncol. Rep. 22, 1479 (2009), (4) M. Endo, Physiol. Rev. 89, 1153 (2009), (5) H. Wang, et al., Eur. J. Pharmacol. 630, 29 (2010), (6) R. Gal & F. Libersat, PLoS ONE 5, e10019 (2010), (7) C. Cole, et al., CUT (2010), (8) N. Wang, et al., J. Pharmacol. Sci. 123, 25 (2013), (9) C. Li, et al., Oncol. Res. 26, 209 (2018), (10) Y.C. Li, et al., J. Cell Biochem. 119, 2440 (2018)
Quantity	250 mg, Bulk