Procyclidine hydrochloride

SKU: P0608

Category: API's & Intermediates

Synonyms: &alpha , -Cyclohexyl-&alpha , -phenyl-1-pyrrolidinepropanol , Arpicolin , Tricyclamol hydrochloride; 1508-76-5
CAS-Number: C₁₉H₂₉NO · HCl
Molecular Formula: 323.90
Molecular Weight

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (TLC)
Identity: 1H-NMR
Appearance: White to off-white powder

Properties

Solvents: DMOS, DMF, ethanol (all 1 mg/ml) or chloroform.

Short Term Storage: RT
Use / Stability: Stable for at least 2 years after receipt when stored at RT.
Handling Advice: Protect from light and moisture.
Long Term Storage: +4°C
Shipping: AMBIENT

Transportation: Not dangerous goods

Description: Procyclidine is a synthetic anticholinergic agent and atropine-like antispasmodic. It exhibits therapeutic effects against parkinson′s disease and schizophrenia. Procyclidine is an antagonist of muscarinic acetylcholine receptors (Kis = 4.47, 42.66, 7.24, 6.03, and 4.79 nM for M1-5 receptors, respectively). It also affects N-methyl-D-aspartate (NMDA) glutamine and nicotinic acetylcholine receptors to a lower extent.
InChi: InChI=1S/C19H29NO.ClH/c21-19(17-9-3-1-4-10-17,18-11-5-2-6-12-18)13-16-20-14-7-8-15-20;/h1,3-4,9-10,18,21H,2,5-8,11-16H2;1H
References: (1) R.B. Barlow, et al., Br. J. Pharmacol. 72, 277 (1981) , (2) M. Waelbroeck, et al., Eur. J. Pharmacol. 189, 135 (1990) , (3) S. Lazareno, et al., Mol. Pharmacol. 38, 805 (1990) , (4) T. Zarnowski, et al., J. Neural. Transm. Gen. Sect. 97, 1 (1994) , (5) M.L. Sipos, et al., Psychopharmacol. 147, 250 (1999) , (6) V. Jevtovic-Todorovic, et al., Neuropharmacol. 44, 739 (2003) , (7) R. Roesler, et al., J. Clin. Psychopharmacol. 23, 666 (2003)
InChi Key: ZFSPFXJSEHCTTR-UHFFFAOYSA-N
Smiles: OC(C1CCCCC1)(CCN2CCCC2)C3=CC=CC=C3.Cl

Procyclidine is a synthetic anticholinergic agent and atropine-like antispasmodic. It exhibits therapeutic effects against parkinson′s disease and schizophrenia. Procyclidine is an antagonist of muscarinic acetylcholine receptors (Kis = 4.47, 42.66, 7.24, 6.03, and 4.79 nM for M1-5 receptors, respectively). It also affects N-methyl-D-aspartate (NMDA) glutamine and nicotinic acetylcholine receptors to a lower extent.

Artikelnummer: P0608 Kategorie: API's & Intermediates

Zusätzliche Information

Zusätzliche Information

Synonyms	&alpha, -Cyclohexyl-&alpha, -phenyl-1-pyrrolidinepropanol, Arpicolin, Tricyclamol hydrochloride
Purity	≥98% (TLC)
Appearance	White to off-white powder
CAS-Number	1508-76-5
Molecular Formula	C19H29NO · HCl
Molecular Weight	323.90
Identity	1H-NMR
Solvents	DMOS, DMF, ethanol (all 1 mg/ml) or chloroform.
Smiles	OC(C1CCCCC1)(CCN2CCCC2)C3=CC=CC=C3.Cl
InChi Key	ZFSPFXJSEHCTTR-UHFFFAOYSA-N
Shipping	AMBIENT
Short Term Storage	RT
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at RT.
Transportation	Not dangerous goods
References	(1) R.B. Barlow, et al., Br. J. Pharmacol. 72, 277 (1981), (2) M. Waelbroeck, et al., Eur. J. Pharmacol. 189, 135 (1990), (3) S. Lazareno, et al., Mol. Pharmacol. 38, 805 (1990), (4) T. Zarnowski, et al., J. Neural. Transm. Gen. Sect. 97, 1 (1994), (5) M.L. Sipos, et al., Psychopharmacol. 147, 250 (1999), (6) V. Jevtovic-Todorovic, et al., Neuropharmacol. 44, 739 (2003), (7) R. Roesler, et al., J. Clin. Psychopharmacol. 23, 666 (2003)
InChi	InChI=1S/C19H29NO.ClH/c21-19(17-9-3-1-4-10-17,18-11-5-2-6-12-18)13-16-20-14-7-8-15-20;/h1,3-4,9-10,18,21H,2,5-8,11-16H2;1H
Quantity	1 g, 5 g, Bulk