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    Procyclidine hydrochloride

    Available from stock

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      Procyclidine hydrochloride

      SKU
      P0608

      Category: API's & Intermediates

      Synonyms
      &alpha , -Cyclohexyl-&alpha , -phenyl-1-pyrrolidinepropanol , Arpicolin , Tricyclamol hydrochloride
      1508-76-5
      CAS-Number
      C19H29NO · HCl
      Molecular Formula
      323.90
      Molecular Weight

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥98% (TLC)
      Identity
      1H-NMR
      Appearance
      White to off-white powder

      Properties

      Solvents
      DMOS, DMF, ethanol (all 1 mg/ml) or chloroform.
      Short Term Storage
      RT
      Use / Stability
      Stable for at least 2 years after receipt when stored at RT.
      Handling Advice
      Protect from light and moisture.
      Long Term Storage
      +4°C
      Shipping
      AMBIENT
      Transportation
      Not dangerous goods
      Description
      Procyclidine is a synthetic anticholinergic agent and atropine-like antispasmodic. It exhibits therapeutic effects against parkinson′s disease and schizophrenia. Procyclidine is an antagonist of muscarinic acetylcholine receptors (Kis = 4.47, 42.66, 7.24, 6.03, and 4.79 nM for M1-5 receptors, respectively). It also affects N-methyl-D-aspartate (NMDA) glutamine and nicotinic acetylcholine receptors to a lower extent.
      InChi
      InChI=1S/C19H29NO.ClH/c21-19(17-9-3-1-4-10-17,18-11-5-2-6-12-18)13-16-20-14-7-8-15-20;/h1,3-4,9-10,18,21H,2,5-8,11-16H2;1H
      References
      (1) R.B. Barlow, et al., Br. J. Pharmacol. 72, 277 (1981) , (2) M. Waelbroeck, et al., Eur. J. Pharmacol. 189, 135 (1990) , (3) S. Lazareno, et al., Mol. Pharmacol. 38, 805 (1990) , (4) T. Zarnowski, et al., J. Neural. Transm. Gen. Sect. 97, 1 (1994) , (5) M.L. Sipos, et al., Psychopharmacol. 147, 250 (1999) , (6) V. Jevtovic-Todorovic, et al., Neuropharmacol. 44, 739 (2003) , (7) R. Roesler, et al., J. Clin. Psychopharmacol. 23, 666 (2003)
      InChi Key
      ZFSPFXJSEHCTTR-UHFFFAOYSA-N
      Smiles
      OC(C1CCCCC1)(CCN2CCCC2)C3=CC=CC=C3.Cl

      Procyclidine is a synthetic anticholinergic agent and atropine-like antispasmodic. It exhibits therapeutic effects against parkinson′s disease and schizophrenia. Procyclidine is an antagonist of muscarinic acetylcholine receptors (Kis = 4.47, 42.66, 7.24, 6.03, and 4.79 nM for M1-5 receptors, respectively). It also affects N-methyl-D-aspartate (NMDA) glutamine and nicotinic acetylcholine receptors to a lower extent.

      Artikelnummer: P0608 Kategorie: API's & Intermediates
      • Zusätzliche Information

      Zusätzliche Information

      Synonyms

      &alpha, -Cyclohexyl-&alpha, -phenyl-1-pyrrolidinepropanol, Arpicolin, Tricyclamol hydrochloride

      Purity

      ≥98% (TLC)

      Appearance

      White to off-white powder

      CAS-Number

      1508-76-5

      Molecular Formula

      C19H29NO · HCl

      Molecular Weight

      323.90

      Identity

      1H-NMR

      Solvents

      DMOS, DMF, ethanol (all 1 mg/ml) or chloroform.

      Smiles

      OC(C1CCCCC1)(CCN2CCCC2)C3=CC=CC=C3.Cl

      InChi Key

      ZFSPFXJSEHCTTR-UHFFFAOYSA-N

      Shipping

      AMBIENT

      Short Term Storage

      RT

      Long Term Storage

      +4°C

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at RT.

      Transportation

      Not dangerous goods

      References

      (1) R.B. Barlow, et al., Br. J. Pharmacol. 72, 277 (1981), (2) M. Waelbroeck, et al., Eur. J. Pharmacol. 189, 135 (1990), (3) S. Lazareno, et al., Mol. Pharmacol. 38, 805 (1990), (4) T. Zarnowski, et al., J. Neural. Transm. Gen. Sect. 97, 1 (1994), (5) M.L. Sipos, et al., Psychopharmacol. 147, 250 (1999), (6) V. Jevtovic-Todorovic, et al., Neuropharmacol. 44, 739 (2003), (7) R. Roesler, et al., J. Clin. Psychopharmacol. 23, 666 (2003)

      InChi

      InChI=1S/C19H29NO.ClH/c21-19(17-9-3-1-4-10-17,18-11-5-2-6-12-18)13-16-20-14-7-8-15-20;/h1,3-4,9-10,18,21H,2,5-8,11-16H2;1H

      Quantity

      1 g, 5 g, Bulk

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