Specifications
- Purity
- ≥98% (TLC)
- Identity
- 1H-NMR
- Appearance
- White to off-white powder
Properties
- Solvents
- DMOS, DMF, ethanol (all 1 mg/ml) or chloroform.
Category: API's & Intermediates
Procyclidine is a synthetic anticholinergic agent and atropine-like antispasmodic. It exhibits therapeutic effects against parkinson′s disease and schizophrenia. Procyclidine is an antagonist of muscarinic acetylcholine receptors (Kis = 4.47, 42.66, 7.24, 6.03, and 4.79 nM for M1-5 receptors, respectively). It also affects N-methyl-D-aspartate (NMDA) glutamine and nicotinic acetylcholine receptors to a lower extent.
Synonyms | &alpha, -Cyclohexyl-&alpha, -phenyl-1-pyrrolidinepropanol, Arpicolin, Tricyclamol hydrochloride |
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Purity | ≥98% (TLC) |
Appearance | White to off-white powder |
CAS-Number | 1508-76-5 |
Molecular Formula | C19H29NO · HCl |
Molecular Weight | 323.90 |
Identity | 1H-NMR |
Solvents | DMOS, DMF, ethanol (all 1 mg/ml) or chloroform. |
Smiles | OC(C1CCCCC1)(CCN2CCCC2)C3=CC=CC=C3.Cl |
InChi Key | ZFSPFXJSEHCTTR-UHFFFAOYSA-N |
Shipping | AMBIENT |
Short Term Storage | RT |
Long Term Storage | +4°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at RT. |
Transportation | Not dangerous goods |
References | (1) R.B. Barlow, et al., Br. J. Pharmacol. 72, 277 (1981), (2) M. Waelbroeck, et al., Eur. J. Pharmacol. 189, 135 (1990), (3) S. Lazareno, et al., Mol. Pharmacol. 38, 805 (1990), (4) T. Zarnowski, et al., J. Neural. Transm. Gen. Sect. 97, 1 (1994), (5) M.L. Sipos, et al., Psychopharmacol. 147, 250 (1999), (6) V. Jevtovic-Todorovic, et al., Neuropharmacol. 44, 739 (2003), (7) R. Roesler, et al., J. Clin. Psychopharmacol. 23, 666 (2003) |
InChi | InChI=1S/C19H29NO.ClH/c21-19(17-9-3-1-4-10-17,18-11-5-2-6-12-18)13-16-20-14-7-8-15-20;/h1,3-4,9-10,18,21H,2,5-8,11-16H2;1H |
Quantity | 1 g, 5 g, Bulk |