Available from stock

Prostaglandin E1

SKU: P0450

Category: Phytochemicals

Synonyms: (11α,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-enoic acid , Alprostadil , PGE1; 745-65-3
CAS-Number: C₂₀H₃₄O₅
Molecular Formula: 354.49
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Appearance: White to off-white powder
Identity: 1H-NMR

Properties

Solvents: DMSO (30 mg/ml), DMF (50 mg/ml), ethanol (30 mg/ml)

Shipping: BLUE ICE
Short Term Storage: -20°C
Long Term Storage: -20°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at -20°C.

Hazard statements: H301-H361
Precautionary statements: P281-P301 + P310
GHS Symbol: GHS06+GHS08
Signal word: Danger
RIDADR: UN2811
Transportation: Packing Group III

Description: Prostaglandin E1 (PGE1) is an endogenous prostaglandin used as a medication. Its synthetic form, alprostadil, is a vasodilator and smooth muscle relaxant used for several different medical purposes. PGE1 is the theoretical cyclooxygenase metabolite of dihomo-γ,-linolenic acid (DGLA), but it is virtually undetectable in the plasma of normal humans or other animals. Its pharmacology includes vasodilation, hypotension and anti-platelet activities. The IC50 of PGE1 for the inhibition of ADP-induced human platelet aggregation is 40 nM. The vasorelaxant and anti-hypertensive effects of PGE1 are used to treat male erectile dysfunction and to provide emergency vasodilation of the patent ductus arteriosus in infants whose cardiac anomalies require pulmonary shunting for survival.
Smiles: O[C@@H]([C@H](/C=C/[C@@H](O)CCCCC)[C@H]1CCCCCCC(O)=O)CC1=O
InChi Key: GMVPRGQOIOIIMI-DWKJAMRDSA-N
References: (1) F. Okada, et al., Prostaglandins 7, 99 (1974) , (2) P.M. Olley & F. Coceani, Ann. Rev. Med. 32, 375 (1981) , (3) S.J. Kirtland, Prostaglandins Leukot. Essent. Fatty Acids 32, 165 (1988) (Review) , (4) G. Kobzar, et al., Proceed. Est. Acad. Sci. Chem. 40, 179 (1991) , (5) H. Padma-Nathan, et al., New Engl. J. Med. 336, 1 (1997) , (6) W. Cawello, et al., J. Urol. 158, 1403 (1997)
InChi: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1

Prostaglandin E1 (PGE1) is an endogenous prostaglandin used as a medication. Its synthetic form, alprostadil, is a vasodilator and smooth muscle relaxant used for several different medical purposes. PGE1 is the theoretical cyclooxygenase metabolite of dihomo-γ,-linolenic acid (DGLA), but it is virtually undetectable in the plasma of normal humans or other animals. Its pharmacology includes vasodilation, hypotension and anti-platelet activities. The IC50 of PGE1 for the inhibition of ADP-induced human platelet aggregation is 40 nM. The vasorelaxant and anti-hypertensive effects of PGE1 are used to treat male erectile dysfunction and to provide emergency vasodilation of the patent ductus arteriosus in infants whose cardiac anomalies require pulmonary shunting for survival.

SKU: P0450 Category: Phytochemicals

Additional information

Additional information

Synonyms	(11α,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-enoic acid, Alprostadil, PGE1
Purity	≥98% (HPLC)
Appearance	White to off-white powder
CAS-Number	745-65-3
Molecular Formula	C20H34O5
Molecular Weight	354.49
Identity	1H-NMR
Solvents	DMSO (30 mg/ml), DMF (50 mg/ml), ethanol (30 mg/ml)
Smiles	O[C@@H]([C@H](/C=C/[C@@H](O)CCCCC)[C@H]1CCCCCCC(O)=O)CC1=O
InChi Key	GMVPRGQOIOIIMI-DWKJAMRDSA-N
Shipping	BLUE ICE
Short Term Storage	-20°C
Long Term Storage	-20°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at -20°C.
Hazard statements	H301-H361
Precautionary statements	P281-P301 + P310
GHS Symbol	GHS06+GHS08
Signal word	Danger
RIDADR	UN2811
Transportation	Packing Group III
References	(1) F. Okada, et al., Prostaglandins 7, 99 (1974), (2) P.M. Olley & F. Coceani, Ann. Rev. Med. 32, 375 (1981), (3) S.J. Kirtland, Prostaglandins Leukot. Essent. Fatty Acids 32, 165 (1988) (Review), (4) G. Kobzar, et al., Proceed. Est. Acad. Sci. Chem. 40, 179 (1991), (5) H. Padma-Nathan, et al., New Engl. J. Med. 336, 1 (1997), (6) W. Cawello, et al., J. Urol. 158, 1403 (1997)
InChi	InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1
Quantity	5 mg, 10 mg, Bulk