Available from stock

Pseudolaric Acid B

SKU: P0453

Category: Phytochemicals

Synonyms: (-)-Pseudolaric acid B , Pseudolarix acid B , PLAB , PAB , NSC 615488; 82508-31-4
CAS-Number: C₂₃H₂₈O₈
Molecular Formula: 432.46
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Appearance: White to off-white powder
Identity: 1H-NMR

Properties

Solvents: DMSO (10 mg/ml), ethanol (10 mg/ml)

Shipping: AMBIENT
Short Term Storage: RT
Long Term Storage: +4°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at +4°C.

Hazard statements: H301-H361
Precautionary statements: P281-P301 + P310
GHS Symbol: GHS06+GHS08
Signal word: Danger
RIDADR: UN2811
Transportation: Packing Group III

Description: Pseudolaric acid B is a natural diterpenoid isolated from the bark of Pseudolarix kaempferi. It has anti-inflammatory, anticancer, immunosuppressive, antifungal and antifertility properties. Effects relevant to its anticancer properties include, apoptosis and autophagy induction, preventing angiogenesis, microtubule-destabilizing, induction of cell cycle arrest, inhibition of multidrug resistance and inhibition of tumor growth in vivo. It inhibits NF-?B and p38 signaling and has been shown to be a PPARα signaling agonist.
Smiles: O=C(C)O[C@@]12[C@@]3(CC[C@@]2([H])[C@](C)(OC3=O)/C=C/C=C(C)/C(O)=O)CC=C(C(OC)=O)CC1
InChi Key: VDGOFNMYZYBUDT-YDRCMHEVSA-N
References: (1) B.N. Zhou, et al., Planta Med. 47, 35 (1983) , (2) E. Li, et al., J. Nat. Prod. 58, 57 (1995) , (3) M.S. Jardat, et al., Planta Med. 68, 667 (2002) , (4) W.F. Tan, et al., Eur. J. Pharmacol. 499, 219 (2004) , (5) M.H. Li, et al., Clin. Cancer Res. 10, 8266 (2004) , (6) V.K. Wong, et al., Clin. Cancer Res. 11, 6002 (2005) , (7) Y.G. Tong, et al., Mol. Pharmacol. 69, 1226 (2006) , (8) T. Li, et al., J. Cell Biochem. 108, 87 (2009) , (9) G. Ma, et al., J. Cancer Res. Clin. Oncol. 136, 1333 (2010) , (10) L. Hou, et al., J. Cancer Res. Clin. Oncol. 138, 885 (2012) , (11) N. Wei, et al: Phytother. Res. 27, 980 (2013) , (12) J. Tong, et al., Phytother. Res. 27, 885 (2013) , (13) Q. Sun & Y. Li, PLoS One 9, e107830 (2014) , (14) M.L. Liu, et al., Front. Pharmacol. 8, 394 (2017) (Review)
InChi: InChI=1S/C23H28O8/c1-14(18(25)26)6-5-10-21(3)17-9-12-22(20(28)31-21)11-7-16(19(27)29-4)8-13-23(17,22)30-15(2)24/h5-7,10,17H,8-9,11-13H2,1-4H3,(H,25,26)/b10-5+,14-6+/t17-,21+,22+,23-/m0/s1

Pseudolaric acid B is a natural diterpenoid isolated from the bark of Pseudolarix kaempferi. It has anti-inflammatory, anticancer, immunosuppressive, antifungal and antifertility properties. Effects relevant to its anticancer properties include, apoptosis and autophagy induction, preventing angiogenesis, microtubule-destabilizing, induction of cell cycle arrest, inhibition of multidrug resistance and inhibition of tumor growth in vivo. It inhibits NF-?B and p38 signaling and has been shown to be a PPARα signaling agonist.

SKU: P0453 Category: Phytochemicals

Additional information

Additional information

Synonyms	(-)-Pseudolaric acid B, Pseudolarix acid B, PLAB, PAB, NSC 615488
Purity	≥98% (HPLC)
Appearance	White to off-white powder
CAS-Number	82508-31-4
Molecular Formula	C23H28O8
Molecular Weight	432.46
Identity	1H-NMR
Solvents	DMSO (10 mg/ml), ethanol (10 mg/ml)
Smiles	O=C(C)O[C@@]12[C@@]3(CC[C@@]2([H])[C@](C)(OC3=O)/C=C/C=C(C)/C(O)=O)CC=C(C(OC)=O)CC1
InChi Key	VDGOFNMYZYBUDT-YDRCMHEVSA-N
Shipping	AMBIENT
Short Term Storage	RT
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at +4°C.
Hazard statements	H301-H361
Precautionary statements	P281-P301 + P310
GHS Symbol	GHS06+GHS08
Signal word	Danger
RIDADR	UN2811
Transportation	Packing Group III
References	(1) B.N. Zhou, et al., Planta Med. 47, 35 (1983), (2) E. Li, et al., J. Nat. Prod. 58, 57 (1995), (3) M.S. Jardat, et al., Planta Med. 68, 667 (2002), (4) W.F. Tan, et al., Eur. J. Pharmacol. 499, 219 (2004), (5) M.H. Li, et al., Clin. Cancer Res. 10, 8266 (2004), (6) V.K. Wong, et al., Clin. Cancer Res. 11, 6002 (2005), (7) Y.G. Tong, et al., Mol. Pharmacol. 69, 1226 (2006), (8) T. Li, et al., J. Cell Biochem. 108, 87 (2009), (9) G. Ma, et al., J. Cancer Res. Clin. Oncol. 136, 1333 (2010), (10) L. Hou, et al., J. Cancer Res. Clin. Oncol. 138, 885 (2012), (11) N. Wei, et al: Phytother. Res. 27, 980 (2013), (12) J. Tong, et al., Phytother. Res. 27, 885 (2013), (13) Q. Sun & Y. Li, PLoS One 9, e107830 (2014), (14) M.L. Liu, et al., Front. Pharmacol. 8, 394 (2017) (Review)
InChi	InChI=1S/C23H28O8/c1-14(18(25)26)6-5-10-21(3)17-9-12-22(20(28)31-21)11-7-16(19(27)29-4)8-13-23(17,22)30-15(2)24/h5-7,10,17H,8-9,11-13H2,1-4H3,(H,25,26)/b10-5+,14-6+/t17-,21+,22+,23-/m0/s1
Quantity	1 mg, 10 mg, Bulk