Specifications
- Purity
- ≥97% (NMR)
- Appearance
- Solid
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO, water
- Optical Activity
- [α]20/D +13.5°, c = 5 in H2O
Available from stock
S-3-Hydroxyisobutyric acid sodium salt
- SKU
- H0292
Category: Metabolites
- Synonyms
- (S)-β-Hydroxy-isobutyric acid sodium salt , (S)-3-Hydroxy-2-methylpropionic acid sodium salt , S-HIBA , 26543-05-5 (free acid)
- 1893416-17-5
- CAS-Number
- C4H7NaO3
- Molecular Formula
- 126.09
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- RT
- Long Term Storage
- +4°C
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at +4°C.
- Transportation
- Not dangerous goods
- Description
- Intermediate formed in the valine catabolism. It is a reactant of the enzymes involved in branched chain amino acid metabolism 3-hydroxyisobutyrate dehydrogenase and 3-hydroxyisobutyryl-CoA hydrolase and it was found to have increased concentrations in MS patient metabolic profiles. This compound may be used to study the distribution, characterization and kinetics of these enzymes. Shown to inhibit key enzymes of the energy metabolism.
- Smiles
- OC[C@H](C)C([O-])=O.[Na+]
- InChi Key
- RBJZIQZDAZLXEK-DFWYDOINSA-M
- References
- (1) S. Landaas, Clin. Chim. Acta 64, 143 (1975) , (2) J.W. Hawes, et al., Methods Enzymol. 324, 218 (2000) , (3) F.J. Loupatty, et al., Am. J. Hum. Genet. 80, 195 (2007) , (4) C.M. Viegas, et al., Int. J. Dev. Neurosci. 26, 293 (2008) , (5) R.J. Wanders, et al., J. Inherit. Metab. Dis. 35, 5 (2012)
- InChi
- InChI=1S/C4H8O3.Na/c1-3(2-5)4(6)7,/h3,5H,2H2,1H3,(H,6,7),/q,+1/p-1/t3-,/m0./s1
Intermediate formed in the valine catabolism. It is a reactant of the enzymes involved in branched chain amino acid metabolism 3-hydroxyisobutyrate dehydrogenase and 3-hydroxyisobutyryl-CoA hydrolase and it was found to have increased concentrations in MS patient metabolic profiles. This compound may be used to study the distribution, characterization and kinetics of these enzymes. Shown to inhibit key enzymes of the energy metabolism.
Zusätzliche Informationen
| Synonyms | (S)-β-Hydroxy-isobutyric acid sodium salt, (S)-3-Hydroxy-2-methylpropionic acid sodium salt, S-HIBA, 26543-05-5 (free acid) |
|---|---|
| Purity | ≥97% (NMR) |
| Appearance | Solid |
| CAS-Number | 1893416-17-5 |
| Molecular Formula | C4H7NaO3 |
| Molecular Weight | 126.09 |
| Identity | 1H-NMR |
| Solvents | DMSO, water |
| Optical Activity | [α]20/D +13.5°, c = 5 in H2O |
| Smiles | OC[C@H](C)C([O-])=O.[Na+] |
| InChi Key | RBJZIQZDAZLXEK-DFWYDOINSA-M |
| Shipping | AMBIENT |
| Short Term Storage | RT |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Transportation | Not dangerous goods |
| References | (1) S. Landaas, Clin. Chim. Acta 64, 143 (1975), (2) J.W. Hawes, et al., Methods Enzymol. 324, 218 (2000), (3) F.J. Loupatty, et al., Am. J. Hum. Genet. 80, 195 (2007), (4) C.M. Viegas, et al., Int. J. Dev. Neurosci. 26, 293 (2008), (5) R.J. Wanders, et al., J. Inherit. Metab. Dis. 35, 5 (2012) |
| InChi | InChI=1S/C4H8O3.Na/c1-3(2-5)4(6)7,/h3,5H,2H2,1H3,(H,6,7),/q,+1/p-1/t3-,/m0./s1 |
| Quantity | 100 mg, Bulk |
