Specifications
- Purity
- ≥99% (TLC)
- Appearance
- White to off-white powder
- Identity
- 1H-NMR
Properties
- Solvents
- water (40mg/ml), DMSO (40mg/ml), ethanol (20mg/ml).
- Melting Point
- 147-150° C
Documentation
- Safety Data Sheet (SDS)
- CDX T0453 MSDS.pdf
Available from stock
Tetracaine hydrochloride
- SKU
- T0453
Category: API's & Intermediates
- Synonyms
- 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester , Amethocaine hydrochloride
- 136-47-0
- CAS-Number
- C15H24N2O2 · HCl
- Molecular Formula
- 300.8
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- RT
- Long Term Storage
- RT
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at RT.
- Hazard statements
- H301, H317, H319
- Precautionary statements
- P261, P264. P270, P272, P280, P301+P310, P302+P352, P305+P351+P338, P321, P330, P333+P313, P337+P313, P363, P405, P501
- GHS Symbol
- GHS06
- Signal word
- Danger
- RIDADR
- 2811 6.1
- Transportation
- Packing Group III
- Description
- Tetracaine is a potent local anaesthetic and a channel function allosteric inhibitor that blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely. inhibitor of voltage-gated sodium channels such as NaV1.4 and NaV1.8. Shown also to reversibly block nicotinic acetylcholine (ACh) receptors (nAChRs).
- Smiles
- CCCCNC1=CC=C(C(OCCN(C)C)=O)C=C1.Cl
- InChi Key
- PPWHTZKZQNXVAE-UHFFFAOYSA-N
- References
- (1) S. Hishinuma & M.K. Uchida, Br. J. Pharmacol. 103, 1393 (1991) , (2) L. Desmedt, et al., J. Gen. Physiol. 101, 103 (1993) , (3) E. Jaimovich & E. Rojas, Cell Calcium. 15, 356 (1994) , (4) S. Gyoerke, et al., J. Physiol. 500, 297 (1997) , (5) C.L. Overend, et al., J. Physiol. 502, 471 (1997) , (6) D. Mears, et al., Cell Calcium 25, 59 (1999) , (7) R. Cobo, et al., Front. Mol. Neurosci. 11, 193 (2018)
Tetracaine is a potent local anaesthetic and a channel function allosteric inhibitor that blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely. inhibitor of voltage-gated sodium channels such as NaV1.4 and NaV1.8. Shown also to reversibly block nicotinic acetylcholine (ACh) receptors (nAChRs).
Additional information
| Synonyms | 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester, Amethocaine hydrochloride |
|---|---|
| Purity | ≥99% (TLC) |
| Appearance | White to off-white powder |
| CAS-Number | 136-47-0 |
| Molecular Formula | C15H24N2O2 · HCl |
| Molecular Weight | 300.8 |
| Identity | 1H-NMR |
| Solvents | water (40mg/ml), DMSO (40mg/ml), ethanol (20mg/ml). |
| Melting Point | 147-150° C |
| Smiles | CCCCNC1=CC=C(C(OCCN(C)C)=O)C=C1.Cl |
| InChi Key | PPWHTZKZQNXVAE-UHFFFAOYSA-N |
| Shipping | AMBIENT |
| Short Term Storage | RT |
| Long Term Storage | RT |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at RT. |
| Hazard statements | H301, H317, H319 |
| Precautionary statements | P261, P264. P270, P272, P280, P301+P310, P302+P352, P305+P351+P338, P321, P330, P333+P313, P337+P313, P363, P405, P501 |
| GHS Symbol | GHS06 |
| Signal word | Danger |
| RIDADR | 2811 6.1 |
| Transportation | Packing Group III |
| References | (1) S. Hishinuma & M.K. Uchida, Br. J. Pharmacol. 103, 1393 (1991), (2) L. Desmedt, et al., J. Gen. Physiol. 101, 103 (1993), (3) E. Jaimovich & E. Rojas, Cell Calcium. 15, 356 (1994), (4) S. Gyoerke, et al., J. Physiol. 500, 297 (1997), (5) C.L. Overend, et al., J. Physiol. 502, 471 (1997), (6) D. Mears, et al., Cell Calcium 25, 59 (1999), (7) R. Cobo, et al., Front. Mol. Neurosci. 11, 193 (2018) |
| Quantity | 5 g, 25 g, 50 g, Bulk |
