Available from stock

(±)-Lisofylline

SKU: H0117

Category: API's & Intermediates

Synonyms: 1-(5'-Hydroxyhexyl)-3,7-dimethylxanthine , LSF , BL 194 , CT-1501R , 5-Hydroxy pentoxifylline; 6493-06-7
CAS-Number: C₁₃H₂₀N₄O₃
Molecular Formula: 280.3
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥99% (HPLC)
Appearance: White powder
Identity: 1H-NMR

Properties

Solvents: chloroform

Documentation

Safety Data Sheet (SDS): CDX H0117 MSDS.pdf

Shipping: AMBIENT
Short Term Storage: +4°C
Long Term Storage: -20°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at -20°C.

Transportation: Not dangerous goods

Description: Synthetic methylxanthine metabolite of pentoxifylline. Potent anti-inflammatory agent in which only the (?) optical isomer is biologically active. Inhibits the generation of phosphatidic acid from cytokine-activated lysophosphatidic acyl transferase (LPAAT), which has been shown to protect mice from endotoxic shock. Decreases lipid peroxidation in vitr oand in vivo. Suppresses the production of the proinflammatory cytokine IFN-gamma, inhibits IL-12-mediated STAT-4 activation, enhances glucose-stimulated beta-cell insulin secretion, reducing the onset of diabetes in a non-obese diabetic mouse model, and blocks autoimmune deterioration of pancreatic beta cells in non-obese diabetic mice. Compound can be used as analytical reference material.
Smiles: CC(O)CCCCN1C(=O)N(C)C2=C(N(C)C=N2)C1=O
InChi Key: NSMXQKNUPPXBRG-UHFFFAOYSA-N
References: (1) G.C. Rice, et al.: PNAS 91, 3857 (1994) , (2) E. Clarke, et al.: Cancer Res. 56, 105 (1996) , (3) N. Hasegawa, et al.: Am. J. Respir. Crit. Care Med. 155, 928 (1997) , (4) S. Itani, et al.: Metabolism 50, 553 (2001) , (5) S. Itani, et al.: Diabetes 51, 2005 (2002) , (6) M. Chen, et al.: Endocrinol. 143, 2341 (2002) , (7) Z. Yang, et al.: Ann. N.Y. Acad. Sci. 1005, 409 (2003) , (8) J.S. Striffler, et al:.Metab. Clin. Exp. 53, 290 (2004) , (9) Z. Yang, et al.: Biochem. Pharmacol. 69, 1 (2005) , (10) E. Wyska: Pharmacology 85, 264 (2010)
InChi: InChI=1S/C13H20N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8-9,18H,4-7H2,1-3H3

Synthetic methylxanthine metabolite of pentoxifylline. Potent anti-inflammatory agent in which only the (?) optical isomer is biologically active. Inhibits the generation of phosphatidic acid from cytokine-activated lysophosphatidic acyl transferase (LPAAT), which has been shown to protect mice from endotoxic shock. Decreases lipid peroxidation in vitr oand in vivo. Suppresses the production of the proinflammatory cytokine IFN-gamma, inhibits IL-12-mediated STAT-4 activation, enhances glucose-stimulated beta-cell insulin secretion, reducing the onset of diabetes in a non-obese diabetic mouse model, and blocks autoimmune deterioration of pancreatic beta cells in non-obese diabetic mice. Compound can be used as analytical reference material.

SKU: H0117 Category: API's & Intermediates

Additional information

Additional information

Synonyms	1-(5'-Hydroxyhexyl)-3,7-dimethylxanthine, LSF, BL 194, CT-1501R, 5-Hydroxy pentoxifylline
Purity	≥99% (HPLC)
Appearance	White powder
CAS-Number	6493-06-7
Molecular Formula	C13H20N4O3
Molecular Weight	280.3
Identity	1H-NMR
Solvents	chloroform
Smiles	CC(O)CCCCN1C(=O)N(C)C2=C(N(C)C=N2)C1=O
InChi Key	NSMXQKNUPPXBRG-UHFFFAOYSA-N
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at -20°C.
Transportation	Not dangerous goods
References	(1) G.C. Rice, et al.: PNAS 91, 3857 (1994), (2) E. Clarke, et al.: Cancer Res. 56, 105 (1996), (3) N. Hasegawa, et al.: Am. J. Respir. Crit. Care Med. 155, 928 (1997), (4) S. Itani, et al.: Metabolism 50, 553 (2001), (5) S. Itani, et al.: Diabetes 51, 2005 (2002), (6) M. Chen, et al.: Endocrinol. 143, 2341 (2002), (7) Z. Yang, et al.: Ann. N.Y. Acad. Sci. 1005, 409 (2003), (8) J.S. Striffler, et al:.Metab. Clin. Exp. 53, 290 (2004), (9) Z. Yang, et al.: Biochem. Pharmacol. 69, 1 (2005), (10) E. Wyska: Pharmacology 85, 264 (2010)
InChi	InChI=1S/C13H20N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8-9,18H,4-7H2,1-3H3
Quantity	10 mg, 50 mg, Bulk