• Home
Search

Results for {phrase} ({results_count} of {results_count_total})

Displaying {results_count} results of {results_count_total}

More results...

Generic filters
Filter by Product categories
Bioactive Molecules
Amino Acids, Peptides, Proteins
Carbohydrates
Lipids, Fatty Acids
Metabolites
Phytochemicals
Vitamins
Bioactive Small Molecules
Biopolymers
Detection in Bioanalysis
Fluorescent Detection
Organic Pollutants & Pesticides
Fungicides
Herbicides
Insecticides
Other Pollutants
Pharmaceutically Actives
Antibiotics
API's & Intermediates
Steroids
Reagents and Building Blocks
Reagents for Life Sciences
Buffers
Building Blocks, Intermediates, Reagents
Fluorescent Detection
Linker
Non Fluorescent Detection & Chromogene Detection
Quorum Sensing
Uncategorized
    Industriestrasse 15, CH-9015 St. Gallen, Tel: +41 71 244 48 25
    • 0Shopping Cart
    Chemodex
    • Home
    • Products
    • Catalogs
    • About Chemodex
    • Contact & Distributors
    • Menu Menu
    (±)-Lisofylline

    Available from stock

      Inquiry

      Please fill out the form for your inquiry:



      * required field

      (±)-Lisofylline

      SKU
      H0117

      Category: API's & Intermediates

      Synonyms
      1-(5'-Hydroxyhexyl)-3,7-dimethylxanthine , LSF , BL 194 , CT-1501R , 5-Hydroxy pentoxifylline
      6493-06-7
      CAS-Number
      C13H20N4O3
      Molecular Formula
      280.3
      Molecular Weight

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥99% (HPLC)
      Identity
      1H-NMR
      Appearance
      White powder

      Properties

      Solvents
      chloroform

      Downloads

      Safety Data Sheet
      CDX H0117 MSDS.pdf
      Short Term Storage
      +4°C
      Use / Stability
      Stable for at least 2 years after receipt when stored at -20°C.
      Handling Advice
      Protect from light and moisture.
      Long Term Storage
      -20°C
      Shipping
      AMBIENT
      Transportation
      Not dangerous goods
      Description
      Synthetic methylxanthine metabolite of pentoxifylline. Potent anti-inflammatory agent in which only the (?) optical isomer is biologically active. Inhibits the generation of phosphatidic acid from cytokine-activated lysophosphatidic acyl transferase (LPAAT), which has been shown to protect mice from endotoxic shock. Decreases lipid peroxidation in vitr oand in vivo. Suppresses the production of the proinflammatory cytokine IFN-gamma, inhibits IL-12-mediated STAT-4 activation, enhances glucose-stimulated beta-cell insulin secretion, reducing the onset of diabetes in a non-obese diabetic mouse model, and blocks autoimmune deterioration of pancreatic beta cells in non-obese diabetic mice. Compound can be used as analytical reference material.
      InChi
      InChI=1S/C13H20N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8-9,18H,4-7H2,1-3H3
      References
      (1) G.C. Rice, et al.: PNAS 91, 3857 (1994) , (2) E. Clarke, et al.: Cancer Res. 56, 105 (1996) , (3) N. Hasegawa, et al.: Am. J. Respir. Crit. Care Med. 155, 928 (1997) , (4) S. Itani, et al.: Metabolism 50, 553 (2001) , (5) S. Itani, et al.: Diabetes 51, 2005 (2002) , (6) M. Chen, et al.: Endocrinol. 143, 2341 (2002) , (7) Z. Yang, et al.: Ann. N.Y. Acad. Sci. 1005, 409 (2003) , (8) J.S. Striffler, et al:.Metab. Clin. Exp. 53, 290 (2004) , (9) Z. Yang, et al.: Biochem. Pharmacol. 69, 1 (2005) , (10) E. Wyska: Pharmacology 85, 264 (2010)
      InChi Key
      NSMXQKNUPPXBRG-UHFFFAOYSA-N
      Smiles
      CC(O)CCCCN1C(=O)N(C)C2=C(N(C)C=N2)C1=O

      Synthetic methylxanthine metabolite of pentoxifylline. Potent anti-inflammatory agent in which only the (?) optical isomer is biologically active. Inhibits the generation of phosphatidic acid from cytokine-activated lysophosphatidic acyl transferase (LPAAT), which has been shown to protect mice from endotoxic shock. Decreases lipid peroxidation in vitr oand in vivo. Suppresses the production of the proinflammatory cytokine IFN-gamma, inhibits IL-12-mediated STAT-4 activation, enhances glucose-stimulated beta-cell insulin secretion, reducing the onset of diabetes in a non-obese diabetic mouse model, and blocks autoimmune deterioration of pancreatic beta cells in non-obese diabetic mice. Compound can be used as analytical reference material.

      SKU: H0117 Category: API's & Intermediates
      • Additional information

      Additional information

      Synonyms

      1-(5'-Hydroxyhexyl)-3,7-dimethylxanthine, LSF, BL 194, CT-1501R, 5-Hydroxy pentoxifylline

      Purity

      ≥99% (HPLC)

      Appearance

      White powder

      CAS-Number

      6493-06-7

      Molecular Formula

      C13H20N4O3

      Molecular Weight

      280.3

      Identity

      1H-NMR

      Solvents

      chloroform

      Smiles

      CC(O)CCCCN1C(=O)N(C)C2=C(N(C)C=N2)C1=O

      InChi Key

      NSMXQKNUPPXBRG-UHFFFAOYSA-N

      Shipping

      AMBIENT

      Short Term Storage

      +4°C

      Long Term Storage

      -20°C

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at -20°C.

      Transportation

      Not dangerous goods

      References

      (1) G.C. Rice, et al.: PNAS 91, 3857 (1994), (2) E. Clarke, et al.: Cancer Res. 56, 105 (1996), (3) N. Hasegawa, et al.: Am. J. Respir. Crit. Care Med. 155, 928 (1997), (4) S. Itani, et al.: Metabolism 50, 553 (2001), (5) S. Itani, et al.: Diabetes 51, 2005 (2002), (6) M. Chen, et al.: Endocrinol. 143, 2341 (2002), (7) Z. Yang, et al.: Ann. N.Y. Acad. Sci. 1005, 409 (2003), (8) J.S. Striffler, et al:.Metab. Clin. Exp. 53, 290 (2004), (9) Z. Yang, et al.: Biochem. Pharmacol. 69, 1 (2005), (10) E. Wyska: Pharmacology 85, 264 (2010)

      InChi

      InChI=1S/C13H20N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8-9,18H,4-7H2,1-3H3

      Quantity

      10 mg, 50 mg, Bulk

      Related products

      • 4-trans-Hydroxy-glibenclamide

        4-trans-Hydroxy-glibenclamide

        Purity: ≥97% (HPLC)CAS-Number: 23155-00-2SKU: H0027

        Read more Show Details
      • Decitabine

        Decitabine

        Purity: ≥99% (HPLC)CAS-Number: 2353-33-5SKU: A0563

        Read more Show Details
      • Cefpodoxime

        Cefpodoxime

        Purity: ≥98%CAS-Number: 80210-62-4SKU: C0361

        Read more Show Details
      • Articaine hydrochloride

        Articaine hydrochloride

        Purity: ≥98% (HPLC)CAS-Number: 23964-57-0SKU: A0564

        Read more Show Details
      © Copyright - Chemodex Ltd. - Customized Molecules developed in Switzerland
      • Home
      • All products
      • Order and delivery information
      • Disclaimer
      • Privacy policy
      • About this site
      1-Hydroxy-1,2-benziodoxol-3-one 1-Hydroxy-1 Hydroxytyrosol Hydroxytyrosol Scroll to top