Specifications
- Purity
- ≥99% (HPLC)
- Identity
- 1H-NMR
- Appearance
- White powder
Properties
- Solvents
- chloroform
Downloads
- Safety Data Sheet
- CDX H0117 MSDS.pdf
Available from stock
(±)-Lisofylline
- SKU
- H0117
Category: API's & Intermediates
- Synonyms
- 1-(5'-Hydroxyhexyl)-3,7-dimethylxanthine , LSF , BL 194 , CT-1501R , 5-Hydroxy pentoxifylline
- 6493-06-7
- CAS-Number
- C13H20N4O3
- Molecular Formula
- 280.3
- Molecular Weight
- Short Term Storage
- +4°C
- Use / Stability
- Stable for at least 2 years after receipt when stored at -20°C.
- Handling Advice
- Protect from light and moisture.
- Long Term Storage
- -20°C
- Shipping
- AMBIENT
- Transportation
- Not dangerous goods
- Description
- Synthetic methylxanthine metabolite of pentoxifylline. Potent anti-inflammatory agent in which only the (?) optical isomer is biologically active. Inhibits the generation of phosphatidic acid from cytokine-activated lysophosphatidic acyl transferase (LPAAT), which has been shown to protect mice from endotoxic shock. Decreases lipid peroxidation in vitr oand in vivo. Suppresses the production of the proinflammatory cytokine IFN-gamma, inhibits IL-12-mediated STAT-4 activation, enhances glucose-stimulated beta-cell insulin secretion, reducing the onset of diabetes in a non-obese diabetic mouse model, and blocks autoimmune deterioration of pancreatic beta cells in non-obese diabetic mice. Compound can be used as analytical reference material.
- InChi
- InChI=1S/C13H20N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8-9,18H,4-7H2,1-3H3
- References
- (1) G.C. Rice, et al.: PNAS 91, 3857 (1994) , (2) E. Clarke, et al.: Cancer Res. 56, 105 (1996) , (3) N. Hasegawa, et al.: Am. J. Respir. Crit. Care Med. 155, 928 (1997) , (4) S. Itani, et al.: Metabolism 50, 553 (2001) , (5) S. Itani, et al.: Diabetes 51, 2005 (2002) , (6) M. Chen, et al.: Endocrinol. 143, 2341 (2002) , (7) Z. Yang, et al.: Ann. N.Y. Acad. Sci. 1005, 409 (2003) , (8) J.S. Striffler, et al:.Metab. Clin. Exp. 53, 290 (2004) , (9) Z. Yang, et al.: Biochem. Pharmacol. 69, 1 (2005) , (10) E. Wyska: Pharmacology 85, 264 (2010)
- InChi Key
- NSMXQKNUPPXBRG-UHFFFAOYSA-N
- Smiles
- CC(O)CCCCN1C(=O)N(C)C2=C(N(C)C=N2)C1=O
Synthetic methylxanthine metabolite of pentoxifylline. Potent anti-inflammatory agent in which only the (?) optical isomer is biologically active. Inhibits the generation of phosphatidic acid from cytokine-activated lysophosphatidic acyl transferase (LPAAT), which has been shown to protect mice from endotoxic shock. Decreases lipid peroxidation in vitr oand in vivo. Suppresses the production of the proinflammatory cytokine IFN-gamma, inhibits IL-12-mediated STAT-4 activation, enhances glucose-stimulated beta-cell insulin secretion, reducing the onset of diabetes in a non-obese diabetic mouse model, and blocks autoimmune deterioration of pancreatic beta cells in non-obese diabetic mice. Compound can be used as analytical reference material.
Additional information
| Synonyms | 1-(5'-Hydroxyhexyl)-3,7-dimethylxanthine, LSF, BL 194, CT-1501R, 5-Hydroxy pentoxifylline |
|---|---|
| Purity | ≥99% (HPLC) |
| Appearance | White powder |
| CAS-Number | 6493-06-7 |
| Molecular Formula | C13H20N4O3 |
| Molecular Weight | 280.3 |
| Identity | 1H-NMR |
| Solvents | chloroform |
| Smiles | CC(O)CCCCN1C(=O)N(C)C2=C(N(C)C=N2)C1=O |
| InChi Key | NSMXQKNUPPXBRG-UHFFFAOYSA-N |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Transportation | Not dangerous goods |
| References | (1) G.C. Rice, et al.: PNAS 91, 3857 (1994), (2) E. Clarke, et al.: Cancer Res. 56, 105 (1996), (3) N. Hasegawa, et al.: Am. J. Respir. Crit. Care Med. 155, 928 (1997), (4) S. Itani, et al.: Metabolism 50, 553 (2001), (5) S. Itani, et al.: Diabetes 51, 2005 (2002), (6) M. Chen, et al.: Endocrinol. 143, 2341 (2002), (7) Z. Yang, et al.: Ann. N.Y. Acad. Sci. 1005, 409 (2003), (8) J.S. Striffler, et al:.Metab. Clin. Exp. 53, 290 (2004), (9) Z. Yang, et al.: Biochem. Pharmacol. 69, 1 (2005), (10) E. Wyska: Pharmacology 85, 264 (2010) |
| InChi | InChI=1S/C13H20N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8-9,18H,4-7H2,1-3H3 |
| Quantity | 10 mg, 50 mg, Bulk |
