Specifications
- Purity
- ≥98% (NMR)
- Appearance
- Off-white to brown powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO (20mg/ml) or chloroform
Available from stock
10-Acetylphenoxazine
- SKU
- A0694
Category: Fluorescent Detection
- Synonyms
- HJ-PI01, 1-(10H-Phenoxazin-10-yl)ethan-1-one, N-Acetylphenoxazine
- 6192-43-4
- CAS-Number
- C14H11NO2
- Molecular Formula
- 225.24
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- RT
- Long Term Storage
- +4°C
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at +4°C.
- Hazard statements
- H302-H315-H319
- Precautionary statements
- P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330
- GHS Symbol
- GHS07
- Signal word
- Warning
- Transportation
- Not dangerous goods
- Description
- Phenoxazines are tricyclic heterocycles which have found use as therapeutic agents and scaffolds in medicinal chemistry. Due to their photophysical properties phenoxazines have been applied also as dyes in dye-sensitized solar cells and chemosensors. 10-Acetylphenoxazine be used as an intermediate and building block in organic synthesis of dyes, polymers, biochemical inhibitors or radical-trapping antioxidants. 10-Acetylphenoxazine has been described as an orally active Pim-2 inhibitor. It induces apoptosis and autophagic cell death of cancer cells in the µM range.
- Smiles
- O=C(N1C=2C=CC=CC2OC=3C=CC=CC31)C
- InChi Key
- MXVOQCUXOQFIHU-UHFFFAOYSA-N
- References
- (1) H. Kamogawa, et al., J. Polymer Sci. Polymer Chem. Ed. 19, 2571 (1981) , (2) V. Hernandez-Olmos, et al., J. Med. Chem. 55, 9576 (2012) , (3) Y.-Q. Zhao, et al, Acta Pharmacol. Sin. 37, 1237 (2016) , (4) L.A. Farmer, et al., J. Org. Chem. 82, 10523 (2017)
- InChi
- InChI=1S/C14H11NO2/c1-10(16)15-11-6-2-4-8-13(11)17-14-9-5-3-7-12(14)15/h2-9H,1H3
Phenoxazines are tricyclic heterocycles which have found use as therapeutic agents and scaffolds in medicinal chemistry. Due to their photophysical properties phenoxazines have been applied also as dyes in dye-sensitized solar cells and chemosensors. 10-Acetylphenoxazine be used as an intermediate and building block in organic synthesis of dyes, polymers, biochemical inhibitors or radical-trapping antioxidants. 10-Acetylphenoxazine has been described as an orally active Pim-2 inhibitor. It induces apoptosis and autophagic cell death of cancer cells in the µM range.
Additional information
| Synonyms | HJ-PI01, 1-(10H-Phenoxazin-10-yl)ethan-1-one, N-Acetylphenoxazine |
|---|---|
| Purity | ≥98% (NMR) |
| Appearance | Off-white to brown powder |
| CAS-Number | 6192-43-4 |
| Molecular Formula | C14H11NO2 |
| Molecular Weight | 225.24 |
| Identity | 1H-NMR |
| Solvents | DMSO (20mg/ml) or chloroform |
| Smiles | O=C(N1C=2C=CC=CC2OC=3C=CC=CC31)C |
| InChi Key | MXVOQCUXOQFIHU-UHFFFAOYSA-N |
| Shipping | AMBIENT |
| Short Term Storage | RT |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Hazard statements | H302-H315-H319 |
| Precautionary statements | P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330 |
| GHS Symbol | GHS07 |
| Signal word | Warning |
| Transportation | Not dangerous goods |
| References | (1) H. Kamogawa, et al., J. Polymer Sci. Polymer Chem. Ed. 19, 2571 (1981), (2) V. Hernandez-Olmos, et al., J. Med. Chem. 55, 9576 (2012), (3) Y.-Q. Zhao, et al, Acta Pharmacol. Sin. 37, 1237 (2016), (4) L.A. Farmer, et al., J. Org. Chem. 82, 10523 (2017) |
| InChi | InChI=1S/C14H11NO2/c1-10(16)15-11-6-2-4-8-13(11)17-14-9-5-3-7-12(14)15/h2-9H,1H3 |
| Quantity | 5 mg, 10 mg, 25 mg, Bulk |
