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      2,5-Dioxopyrrolidin-1-yl propanoate

      SKU
      D0489

      Category: Building Blocks, Intermediates, Reagents

      Synonyms
      N-(Propionyloxy)succinimide , N-succinimidyl propionate , NSP , Propionyl-Osu , 1-(1-Oxopropoxy)-2,5-pyrrolidinedione
      30364-55-7
      CAS-Number
      C7H9NO4
      Molecular Formula
      171.15
      Molecular Weight

      For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥95%
      Appearance
      White to off-white powder
      Identity
      1H-NMR

      Properties

      Solvents
      chloroform

      Documentation

      Safety Data Sheet (SDS)
      CDX D0489 MSDS.pdf
      Shipping
      AMBIENT
      Short Term Storage
      RT
      Long Term Storage
      +4°C
      Handling Advice
      Protect from light and moisture.
      Use / Stability
      Stable for at least 2 years after receipt when stored at +4°C.
      Hazard statements
      H315, H319, H335
      Precautionary statements
      P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P332+P313, P337+P313, P362, P403+P233, P405, P501
      GHS Symbol
      GHS07
      Signal word
      Warning
      Transportation
      Not dangerous goods
      Description
      Biochemical for proteomics research use. Amine-specific protein-acylating agent. Used for derivatization of biogenic amines for hplc analysis. Recent stuides use this agent for derivatization of histone post-translational modifications. The compound has been used in several studies describing this well established reagent for the introduction of a tritium label into proteins or other biologicals. The retrograde transport of protein components of sciatic nerve axons has been demonstrated by direct labelling of the protein using [3H]NSP in vivo.
      Smiles
      CCC(ON1C(CCC1=O)=O)=O
      InChi Key
      AASBXERNXVFUEJ-UHFFFAOYSA-N
      References
      (1) J.C. Hedreen & G.C. Holm, Brain Res. Bull. 7, 665 (1981) , (2) Y.S. Tang, J. Labelled Comp. Radiopharm. 20, 277 (1982) , (3) U. Kummer, Meth. Enzymol. 121, 670 (1986) , (4) R. Liao, et al., Anal. Chem. 85, 2253 (2013) , (5) J.Chen, et al., Anal. Chim. Acta 886, 107 (2015)
      InChi
      InChI=1S/C7H9NO4/c1-2-7(11)12-8-5(9)3-4-6(8)10/h2-4H2,1H3

      Biochemical for proteomics research use. Amine-specific protein-acylating agent. Used for derivatization of biogenic amines for hplc analysis. Recent stuides use this agent for derivatization of histone post-translational modifications. The compound has been used in several studies describing this well established reagent for the introduction of a tritium label into proteins or other biologicals. The retrograde transport of protein components of sciatic nerve axons has been demonstrated by direct labelling of the protein using [3H]NSP in vivo.

      SKU: D0489 Category: Building Blocks, Intermediates, Reagents
      • Additional information

      Additional information

      Synonyms

      N-(Propionyloxy)succinimide, N-succinimidyl propionate, NSP, Propionyl-Osu, 1-(1-Oxopropoxy)-2,5-pyrrolidinedione

      Purity

      ≥95%

      Appearance

      White to off-white powder

      CAS-Number

      30364-55-7

      Molecular Formula

      C7H9NO4

      Molecular Weight

      171.15

      Identity

      1H-NMR

      Solvents

      chloroform

      Smiles

      CCC(ON1C(CCC1=O)=O)=O

      InChi Key

      AASBXERNXVFUEJ-UHFFFAOYSA-N

      Shipping

      AMBIENT

      Short Term Storage

      RT

      Long Term Storage

      +4°C

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at +4°C.

      Hazard statements

      H315, H319, H335

      Precautionary statements

      P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P332+P313, P337+P313, P362, P403+P233, P405, P501

      GHS Symbol

      GHS07

      Signal word

      Warning

      Transportation

      Not dangerous goods

      References

      (1) J.C. Hedreen & G.C. Holm, Brain Res. Bull. 7, 665 (1981), (2) Y.S. Tang, J. Labelled Comp. Radiopharm. 20, 277 (1982), (3) U. Kummer, Meth. Enzymol. 121, 670 (1986), (4) R. Liao, et al., Anal. Chem. 85, 2253 (2013), (5) J.Chen, et al., Anal. Chim. Acta 886, 107 (2015)

      InChi

      InChI=1S/C7H9NO4/c1-2-7(11)12-8-5(9)3-4-6(8)10/h2-4H2,1H3

      Quantity

      250 mg, 500 mg, Bulk

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