Available from stock

2,5-Dioxopyrrolidin-1-yl propanoate

SKU: D0489

Category: Building Blocks, Intermediates, Reagents

Synonyms: N-(Propionyloxy)succinimide , N-succinimidyl propionate , NSP , Propionyl-Osu , 1-(1-Oxopropoxy)-2,5-pyrrolidinedione; 30364-55-7
CAS-Number: C₇H₉NO₄
Molecular Formula: 171.15
Molecular Weight

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥95%
Appearance: White to off-white powder
Identity: 1H-NMR

Properties

Solvents: chloroform

Downloads

Safety Data Sheet: CDX D0489 MSDS.pdf

Shipping: AMBIENT
Short Term Storage: RT
Long Term Storage: +4°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at +4°C.

Hazard statements: H315, H319, H335
Precautionary statements: P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P332+P313, P337+P313, P362, P403+P233, P405, P501
GHS Symbol: GHS07
Signal word: Warning
Transportation: Not dangerous goods

Description: Biochemical for proteomics research use. Amine-specific protein-acylating agent. Used for derivatization of biogenic amines for hplc analysis. Recent stuides use this agent for derivatization of histone post-translational modifications. The compound has been used in several studies describing this well established reagent for the introduction of a tritium label into proteins or other biologicals. The retrograde transport of protein components of sciatic nerve axons has been demonstrated by direct labelling of the protein using [3H]NSP in vivo.
Smiles: CCC(ON1C(CCC1=O)=O)=O
InChi Key: AASBXERNXVFUEJ-UHFFFAOYSA-N
References: (1) J.C. Hedreen & G.C. Holm, Brain Res. Bull. 7, 665 (1981) , (2) Y.S. Tang, J. Labelled Comp. Radiopharm. 20, 277 (1982) , (3) U. Kummer, Meth. Enzymol. 121, 670 (1986) , (4) R. Liao, et al., Anal. Chem. 85, 2253 (2013) , (5) J.Chen, et al., Anal. Chim. Acta 886, 107 (2015)
InChi: InChI=1S/C7H9NO4/c1-2-7(11)12-8-5(9)3-4-6(8)10/h2-4H2,1H3

Biochemical for proteomics research use. Amine-specific protein-acylating agent. Used for derivatization of biogenic amines for hplc analysis. Recent stuides use this agent for derivatization of histone post-translational modifications. The compound has been used in several studies describing this well established reagent for the introduction of a tritium label into proteins or other biologicals. The retrograde transport of protein components of sciatic nerve axons has been demonstrated by direct labelling of the protein using [3H]NSP in vivo.

SKU: D0489 Category: Building Blocks, Intermediates, Reagents

Additional information

Additional information

Synonyms	N-(Propionyloxy)succinimide, N-succinimidyl propionate, NSP, Propionyl-Osu, 1-(1-Oxopropoxy)-2,5-pyrrolidinedione
Purity	≥95%
Appearance	White to off-white powder
CAS-Number	30364-55-7
Molecular Formula	C7H9NO4
Molecular Weight	171.15
Identity	1H-NMR
Solvents	chloroform
Smiles	CCC(ON1C(CCC1=O)=O)=O
InChi Key	AASBXERNXVFUEJ-UHFFFAOYSA-N
Shipping	AMBIENT
Short Term Storage	RT
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at +4°C.
Hazard statements	H315, H319, H335
Precautionary statements	P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P332+P313, P337+P313, P362, P403+P233, P405, P501
GHS Symbol	GHS07
Signal word	Warning
Transportation	Not dangerous goods
References	(1) J.C. Hedreen & G.C. Holm, Brain Res. Bull. 7, 665 (1981), (2) Y.S. Tang, J. Labelled Comp. Radiopharm. 20, 277 (1982), (3) U. Kummer, Meth. Enzymol. 121, 670 (1986), (4) R. Liao, et al., Anal. Chem. 85, 2253 (2013), (5) J.Chen, et al., Anal. Chim. Acta 886, 107 (2015)
InChi	InChI=1S/C7H9NO4/c1-2-7(11)12-8-5(9)3-4-6(8)10/h2-4H2,1H3
Quantity	250 mg, 500 mg, Bulk