3-cis-Hydroxyglibenclamide

SKU: H0030

Category: API's & Intermediates

Synonyms: 3-cis-Hydroxycyclohexyl glyburide , cis-3-Hydroxyglyburide; 23074-02-4
CAS-Number: C₂₃H₂₈ClN₃O₆S
Molecular Formula: 510.00
Molecular Weight

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥97% (HPLC)
Identity: 1H-NMR
Appearance: White to off-white powder

Properties

Melting Point: 191-193°C
Solvents: DMSO (slightly), methanol (slightly)

Downloads

Safety Data Sheet: CDX H0030 MSDS.pdf

Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at -20°C.
Long Term Storage: -20°C
Short Term Storage: +4°C
Shipping: AMBIENT

Transportation: Not dangerous goods
Signal word: Warning
GHS Symbol: GHS07
Precautionary statements: P280-P305 + P351 + P338-P337 + P313
Hazard statements: H315-H319-H335

Description: M2-Metabolite of the antidiabetic compound glyburide. Antidiabetic reagent. Shows 50% hypoglycaemic activity of the parent compound, by increasing insulin secretion. Compound can be used as analytical reference material.
InChi: InChI=1S/C23H28ClN3O6S/c1-33-21-10-7-16(24)13-20(21)22(29)25-12-11-15-5-8-19(9-6-15)34(31,32)27-23(30)26-17-3-2-4-18(28)14-17/h5-10,13,17-18,28H,2-4,11-12,14H2,1H3,(H,25,29)(H2,26,27,30)/t17-,18+/m0/s1
References: (1) W. Heptner, et al. , Pharmaceut. Res. 5, 215 (1984) , (2) T. Rydberg, et al. , J. Chromatogr. 564, 223 (1991) , (3) T. Rydberg, et al. , Diabetes Care 17, 1026 (1994) , (4) T. Rydberg, et al. , J. Clin. Pharm. Ther. 20, 283 (1995) , (5) T. Rydberg, et al. , Br. J. Clin. Pharm. 43, 373 (1997)
InChi Key: VFBAJFAMXTVSQA-ZWKOTPCHSA-N
Smiles: COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)N[C@H]3CCC[C@H](C3)O

M2-Metabolite of the antidiabetic compound glyburide. Antidiabetic reagent. Shows 50% hypoglycaemic activity of the parent compound, by increasing insulin secretion. Compound can be used as analytical reference material.

SKU: H0030 Category: API's & Intermediates

Additional information

Additional information

Synonyms	3-cis-Hydroxycyclohexyl glyburide, cis-3-Hydroxyglyburide
Purity	≥97% (HPLC)
Appearance	White to off-white powder
CAS-Number	23074-02-4
Molecular Formula	C23H28ClN3O6S
Molecular Weight	510.00
Identity	1H-NMR
Solvents	DMSO (slightly), methanol (slightly)
Melting Point	191-193°C
Smiles	COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)N[C@H]3CCC[C@H](C3)O
InChi Key	VFBAJFAMXTVSQA-ZWKOTPCHSA-N
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at -20°C.
Hazard statements	H315-H319-H335
Precautionary statements	P280-P305 + P351 + P338-P337 + P313
GHS Symbol	GHS07
Signal word	Warning
Transportation	Not dangerous goods
References	(1) W. Heptner, et al., Pharmaceut. Res. 5, 215 (1984), (2) T. Rydberg, et al., J. Chromatogr. 564, 223 (1991), (3) T. Rydberg, et al., Diabetes Care 17, 1026 (1994), (4) T. Rydberg, et al., J. Clin. Pharm. Ther. 20, 283 (1995), (5) T. Rydberg, et al., Br. J. Clin. Pharm. 43, 373 (1997)
InChi	InChI=1S/C23H28ClN3O6S/c1-33-21-10-7-16(24)13-20(21)22(29)25-12-11-15-5-8-19(9-6-15)34(31,32)27-23(30)26-17-3-2-4-18(28)14-17/h5-10,13,17-18,28H,2-4,11-12,14H2,1H3,(H,25,29)(H2,26,27,30)/t17-,18+/m0/s1
Quantity	1 mg, 5 mg, Bulk