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    3-cis-Hydroxyglibenclamide

    Available from stock

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      3-cis-Hydroxyglibenclamide

      SKU
      H0030

      Category: API's & Intermediates

      Synonyms
      3-cis-Hydroxycyclohexyl glyburide , cis-3-Hydroxyglyburide
      23074-02-4
      CAS-Number
      C23H28ClN3O6S
      Molecular Formula
      510.00
      Molecular Weight

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥97% (HPLC)
      Identity
      1H-NMR
      Appearance
      White to off-white powder

      Properties

      Melting Point
      191-193°C
      Solvents
      DMSO (slightly), methanol (slightly)

      Downloads

      Safety Data Sheet
      CDX H0030 MSDS.pdf
      Handling Advice
      Protect from light and moisture.
      Use / Stability
      Stable for at least 2 years after receipt when stored at -20°C.
      Long Term Storage
      -20°C
      Short Term Storage
      +4°C
      Shipping
      AMBIENT
      Transportation
      Not dangerous goods
      Signal word
      Warning
      GHS Symbol
      GHS07
      Precautionary statements
      P280-P305 + P351 + P338-P337 + P313
      Hazard statements
      H315-H319-H335
      Description
      M2-Metabolite of the antidiabetic compound glyburide. Antidiabetic reagent. Shows 50% hypoglycaemic activity of the parent compound, by increasing insulin secretion. Compound can be used as analytical reference material.
      InChi
      InChI=1S/C23H28ClN3O6S/c1-33-21-10-7-16(24)13-20(21)22(29)25-12-11-15-5-8-19(9-6-15)34(31,32)27-23(30)26-17-3-2-4-18(28)14-17/h5-10,13,17-18,28H,2-4,11-12,14H2,1H3,(H,25,29)(H2,26,27,30)/t17-,18+/m0/s1
      References
      (1) W. Heptner, et al. , Pharmaceut. Res. 5, 215 (1984) , (2) T. Rydberg, et al. , J. Chromatogr. 564, 223 (1991) , (3) T. Rydberg, et al. , Diabetes Care 17, 1026 (1994) , (4) T. Rydberg, et al. , J. Clin. Pharm. Ther. 20, 283 (1995) , (5) T. Rydberg, et al. , Br. J. Clin. Pharm. 43, 373 (1997)
      InChi Key
      VFBAJFAMXTVSQA-ZWKOTPCHSA-N
      Smiles
      COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)N[C@H]3CCC[C@H](C3)O

      M2-Metabolite of the antidiabetic compound glyburide. Antidiabetic reagent. Shows 50% hypoglycaemic activity of the parent compound, by increasing insulin secretion. Compound can be used as analytical reference material.

      SKU: H0030 Category: API's & Intermediates
      • Additional information

      Additional information

      Synonyms

      3-cis-Hydroxycyclohexyl glyburide, cis-3-Hydroxyglyburide

      Purity

      ≥97% (HPLC)

      Appearance

      White to off-white powder

      CAS-Number

      23074-02-4

      Molecular Formula

      C23H28ClN3O6S

      Molecular Weight

      510.00

      Identity

      1H-NMR

      Solvents

      DMSO (slightly), methanol (slightly)

      Melting Point

      191-193°C

      Smiles

      COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)N[C@H]3CCC[C@H](C3)O

      InChi Key

      VFBAJFAMXTVSQA-ZWKOTPCHSA-N

      Shipping

      AMBIENT

      Short Term Storage

      +4°C

      Long Term Storage

      -20°C

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at -20°C.

      Hazard statements

      H315-H319-H335

      Precautionary statements

      P280-P305 + P351 + P338-P337 + P313

      GHS Symbol

      GHS07

      Signal word

      Warning

      Transportation

      Not dangerous goods

      References

      (1) W. Heptner, et al., Pharmaceut. Res. 5, 215 (1984), (2) T. Rydberg, et al., J. Chromatogr. 564, 223 (1991), (3) T. Rydberg, et al., Diabetes Care 17, 1026 (1994), (4) T. Rydberg, et al., J. Clin. Pharm. Ther. 20, 283 (1995), (5) T. Rydberg, et al., Br. J. Clin. Pharm. 43, 373 (1997)

      InChi

      InChI=1S/C23H28ClN3O6S/c1-33-21-10-7-16(24)13-20(21)22(29)25-12-11-15-5-8-19(9-6-15)34(31,32)27-23(30)26-17-3-2-4-18(28)14-17/h5-10,13,17-18,28H,2-4,11-12,14H2,1H3,(H,25,29)(H2,26,27,30)/t17-,18+/m0/s1

      Quantity

      1 mg, 5 mg, Bulk

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