- White to off-white powder
- water (3.3 mg/ml), acidic and basic solutions
Metabolic precursor of the neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline), which are collectively known as catecholamines. This amino acid is produced from L-tyrosine by tyrosine hydroxylase and metabolized by catechol-O-methyl transferase (COMT). L-DOPA is capable of crossing the blood brain barrier where it is converted to dopamine. Formulations containing L-DOPA have been used to increase dopamine concentrations in the brain as a treatment for Parkinson’s disease and stroke recovery. Mediates neurotrophic factor release by the brain and CNS. Used for the treatment of Parkinson’s disease and dopamine-responsive dystonia. In addition it is used, as a cell adhesion molecule in serum-free cultures of anchorage-dependent mammalian cells, to prevent surfaces from fouling by bonding antifouling polymers to a susceptible substrate or to stain melanocytes.
3-(3,4-Dihydroxyphenyl)-L-alanine, L-DOPA, 3-Hydroxy-L-tyrosine, Levodopa
White to off-white powder
water (3.3 mg/ml), acidic and basic solutions
|Short Term Storage|
|Long Term Storage|
Protect from light and moisture.
|Use / Stability|
Stable for at least 2 years after receipt when stored at RT.
P301 + P312 + P330-P305 + P351 + P338
Not dangerous goods
(1) O. Hornykiewicz, Life Sci. 15, 1249 (1974) (Review), (2) Y. Misu, et al., Adv. Pharmacol. 32, 427 (1995) (Review), (3) J.G. Nutt, Adv. Neurol. 69,493 (1996) (Review), (4) R.M. Kostrzewa, et al., Amino Acids 23, 57 (2002) (Review), (5) N.B. Mercuri & G. Bernardi, Trends Pharmacol. Sci. 26, 341 (2005) (Review), (6) M.A. Mena, et al., Curr. Top. Med. Chem. 9, 880 (2009) (Review), (7) H.I. Berends, et al., Eur. J. Phys. Rehabil. Med. 45, 621 (2009) (Review), (8) H. Iderberg, et al., Neuroscience 211, 13 (2012) (Review), (9) Y. Huang, et al., Electrochim. Acta 113, 564 (2013), (10) P. Huot, et al., Pharmacol. Rev. 65, 171 (2013) (Review), (11) J. Tang, et al., Cytotechnology 66, 891 (2014), (12) G. Fichman, et al., ACS Nano. 8, 7220 (2014), (13) M.M. Conti, et al., Neurosci. Biobehav. Rev. (Epub ahead of print) (2018) (Review)
25 g, 100 g, Bulk